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Management and outc...
Management and outcome of muscle-invasive bladder cancer with clinical lymph node metastases. A nationwide population-based study in the bladder cancer data base Sweden (BladderBaSe)
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- Abdul-Sattar Aljabery, Firas (author)
- Linköping University,Linköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland
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- Liedberg, Fredrik (author)
- Lund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,Urology - urothelial cancer, Malmö,Lund University Research Groups,Skåne University Hospital
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- Häggström, Christel (author)
- Uppsala University,Umeå University,Umeå universitet,Enheten för biobanksforskning,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; Department of Biobank Research, Umeå University, Umeå, Sweden,Uppsala Univ, Sweden; Umea Univ, Sweden
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- Ströck, Viveka (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology
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- Hosseini, Abolfazl (author)
- Department of Pelvic Cancer, Karolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Sweden
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- Gårdmark, Truls (author)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Sweden,Danderyd Hospital
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- Sherif, Amir (author)
- Umeå University,Umeå universitet,Urologi och andrologi,Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden,Umea Univ, Sweden
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- Jerlström, Tomas, 1969- (author)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Urology,Orebro Univ, Sweden
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- Malmström, Per-Uno (author)
- Uppsala University
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- Holmberg, Lars (author)
- Uppsala University,King's College London
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- Hagberg, Oskar (author)
- Lund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,Urology - urothelial cancer, Malmö,Lund University Research Groups
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- Jahnson, Staffan (author)
- Linköping University,Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland
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(creator_code:org_t)
- 2019-10-30
- 2019
- English.
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In: Scandinavian journal of urology. - : Informa Healthcare. - 2168-1805 .- 2168-1813. ; 53:5, s. 332-338
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Abstract
Subject headings
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- Purpose: To investigate the clinical management and outcome of patients with muscle-invasive bladder cancer with clinical lymph node involvement, using longitudinal nationwide population-based data.Methods: In the Bladder Cancer Data Base Sweden (BladderBaSe), treatment and survival in patients with urinary bladder cancer clinical stage T2-T4 N + M0 diagnosed between 1997 and 2014 was investigated. Patients´ characteristics were studied in relation to TNM classification, curative or palliative treatment, cancer-specific (CSS) and overall survival (OS). Age at diagnosis was categorised as ≤60, 61-70, 71-80 and >80 years, and time periods were stratified as follows: 1997-2001, 2002-2005, 2006-2010 and 2011-2014.Results: There were 786 patients (72% males) with a median age of 71 years (interquartile range = 64-79 years). The proportion of patients with high comorbidity increased over time. Despite similar low comorbidity, curative treatment was given to 44% and to 70% of those in older (>70 years) and younger age groups, respectively. Curative treatment decreased over time, but chemotherapy and cystectomy increased to 25% during the last time period. Patients with curative treatment had better survival compared to those with palliative treatment, both regarding CSS and OS in the whole cohort and in all age groups.Conclusions: The low proportion of older patients undergoing treatment with curative intent, despite no or limited comorbidity, indicates missed chances of treatment with curative intent. The reasons for an overall decrease in curative treatment over time need to be analysed and the challenge of coping with an increasing proportion of node-positive patients with clinically significant comorbidity needs to be met.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Bladder cancer
- cohort study
- lymph node metastasis
- management
- outcome
- Bladder cancer
- cohort study
- lymph node metastasis
- management
- outcome
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Abdul-Sattar Alj ...
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Liedberg, Fredri ...
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Häggström, Chris ...
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Ströck, Viveka
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Hosseini, Abolfa ...
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Gårdmark, Truls
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Sherif, Amir
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Jerlström, Tomas ...
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Malmström, Per-U ...
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Holmberg, Lars
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Hagberg, Oskar
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Jahnson, Staffan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Scandinavian jou ...
- By the university
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Örebro University
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Umeå University
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Karolinska Institutet
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Linköping University
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Lund University
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University of Gothenburg
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