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Search: WFRF:(Halonen Paivi) > Peer-reviewed > Health-Related Qual...

Health-Related Quality of Life in Metastatic Colorectal Cancer Patients Treated with Curative Resection and/or Local Ablative Therapy or Systemic Therapy in the Finnish RAXO-Study

Lehtomaki, Kaisa (author)
Tampere Univ, Fac Med & Hlth Technol, Arvo Ylpon Katu 34, Tampere 33520, Finland.;Tampere Univ Hosp, Dept Oncol, Tays Canc Ctr, Teiskontie 35, Tampere 33520, Finland.
Stedt, Hanna P. (author)
Kuopio Univ Hosp, Dept Oncol, Puijonlaaksontie 2, Kuopio 70210, Finland.;Univ Eastern Finland, Fac Hlth Sci, Yliopistonranta 1A, Kuopio 70210, Finland.
Österlund, Emerik (author)
Uppsala universitet,Experimentell och klinisk onkologi
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Muhonen, Timo (author)
South Carelia Cent Hosp, Dept Oncol, Valto Kakelan Katu 1, Lappeenranta 53130, Finland.;Joint Municipal Author Hlth Care & Social Serv Ke, Home Care, Sairaalakatu 1, Hyvinkaa 05850, Finland.
Soveri, Leena-Maija (author)
Joint Municipal Author Hlth Care & Social Serv Ke, Home Care, Sairaalakatu 1, Hyvinkaa 05850, Finland.;Univ Helsinki, Dept Oncol, Haartmaninkatu 8, Helsinki 00290, Finland.
Halonen, Paivi (author)
Univ Helsinki, Dept Oncol, Haartmaninkatu 8, Helsinki 00290, Finland.;Helsinki Univ Hosp, Dept Oncol, Haartmaninkatu 4, Helsinki 00290, Finland.
Salminen, Tapio K. (author)
Tampere Univ, Fac Med & Hlth Technol, Arvo Ylpon Katu 34, Tampere 33520, Finland.;Tampere Univ Hosp, Dept Oncol, Tays Canc Ctr, Teiskontie 35, Tampere 33520, Finland.
Kononen, Juha (author)
Cent Finland Cent Hosp, Dept Oncol, Keskussairaalantie 19, Jyvaskyla 40620, Finland.;Docrates Hosp, Docrates Canc Ctr, Saukonpaadenranta 2, Helsinki 00180, Finland.
Kallio, Raija (author)
Oulu Univ Hosp, Dept Oncol, Kajaanintie 50, Oulu 90220, Finland.;Univ Oulu, Dept Oncol, Pentti Kaiteran Katu 1, Oulu 90570, Finland.
Algars, Annika (author)
Turku Univ Hosp, Dept Oncol, Hameentie 11, Turku 20520, Finland.;Univ Turku, Dept Oncol, Kiinanmyllynkatu 10, Turku 20520, Finland.
Heerva, Eetu (author)
Turku Univ Hosp, Dept Oncol, Hameentie 11, Turku 20520, Finland.;Univ Turku, Dept Oncol, Kiinanmyllynkatu 10, Turku 20520, Finland.
Lamminmaki, Annamarja (author)
Kuopio Univ Hosp, Dept Oncol, Puijonlaaksontie 2, Kuopio 70210, Finland.;Univ Eastern Finland, Fac Hlth Sci, Yliopistonranta 1A, Kuopio 70210, Finland.
Uutela, Aki (author)
Helsinki Univ Hosp, Dept Transplantat & Liver Surg, Abdominal Ctr, Haartmaninkatu 4, Helsinki 00290, Finland.;Univ Helsinki, Dept Surg, Haartmaninkatu 8, Helsinki 00290, Finland.
Nordin, Arno (author)
Helsinki Univ Hosp, Dept Transplantat & Liver Surg, Abdominal Ctr, Haartmaninkatu 4, Helsinki 00290, Finland.;Univ Helsinki, Dept Surg, Haartmaninkatu 8, Helsinki 00290, Finland.
Lehto, Juho (author)
Tampere Univ, Fac Med & Hlth Technol, Arvo Ylpon Katu 34, Tampere 33520, Finland.;Tampere Univ Hosp, Dept Oncol, Tays Canc Ctr, Teiskontie 35, Tampere 33520, Finland.;Tampere Univ Hosp, Palliat Care Ctr, Teiskontie 35, Tampere 33520, Finland.
Saarto, Tiina (author)
Univ Helsinki, Dept Oncol, Haartmaninkatu 8, Helsinki 00290, Finland.;Helsinki Univ Hosp, Dept Palliat Care, Ctr Comprehens Canc, Haartmaninkatu 4, Helsinki 00290, Finland.
Sintonen, Harri (author)
Univ Helsinki, Dept Publ Hlth, Tukholmankatu 8B, Helsinki 00290, Finland.
Kellokumpu-Lehtinen, Pirkko-Liisa (author)
Tampere Univ, Fac Med & Hlth Technol, Arvo Ylpon Katu 34, Tampere 33520, Finland.;Tampere Univ Hosp, Dept Oncol, Tays Canc Ctr, Teiskontie 35, Tampere 33520, Finland.
Ristamaki, Raija (author)
Turku Univ Hosp, Dept Oncol, Hameentie 11, Turku 20520, Finland.;Univ Turku, Dept Oncol, Kiinanmyllynkatu 10, Turku 20520, Finland.
Glimelius, Bengt (author)
Uppsala universitet,Experimentell och klinisk onkologi
Isoniemi, Helena (author)
Helsinki Univ Hosp, Dept Transplantat & Liver Surg, Abdominal Ctr, Haartmaninkatu 4, Helsinki 00290, Finland.;Univ Helsinki, Dept Surg, Haartmaninkatu 8, Helsinki 00290, Finland.
Osterlund, Pia (author)
Karolinska Institutet
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Tampere Univ, Fac Med & Hlth Technol, Arvo Ylpon Katu 34, Tampere 33520, Finland;Tampere Univ Hosp, Dept Oncol, Tays Canc Ctr, Teiskontie 35, Tampere 33520, Finland. Kuopio Univ Hosp, Dept Oncol, Puijonlaaksontie 2, Kuopio 70210, Finland.;Univ Eastern Finland, Fac Hlth Sci, Yliopistonranta 1A, Kuopio 70210, Finland. (creator_code:org_t)
2022-03-28
2022
English.
In: Cancers. - : MDPI. - 2072-6694. ; 14:7
Related links:
https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Metastatic colorectal cancer is the second most common cause of cancer death. Long-term survival and cure can be achieved after intensive treatments, including metastasectomy, i.e., the removal of all metastases. We wanted to clarify whether a patient health-related quality of life (HRQoL) was reduced by treatments that aimed to maximise metastasectomy rates, and whether HRQoL of treated patients is comparable to the general population. In a cross-sectional study of 444 patients (1751 questionnaires) in the RAXO-study population, we show that HRQoL of intensively treated patients, sometimes with multiple and multisite metastasectomies-usually combined with systemic therapy-remains at a high level during and after curative treatment and when compared with the general population. Good HRQoL was also seen during non-curative treatment from first- to later-lines, with an impaired HRQoL only at end-of-life. Thus, we should aim at maximising metastasectomies since they give long-term survival and sometimes cure with a high HRQoL. Metastasectomy and/or local ablative therapy in metastatic colorectal cancer (mCRC) patients often provide long-term survival. Health-related quality of life (HRQoL) data in curatively treated mCRC are limited. In the RAXO-study that evaluated repeated resectability, a multi-cross-sectional HRQoL substudy with 15D, EQ-5D-3L, QLQ-C30, and QLQ-CR29 questionnaires was conducted. Mean values of patients in different treatment groups were compared with age- and gender-standardized general Finnish populations. The questionnaire completion rate was 444/477 patients (93%, 1751 questionnaires). Mean HRQoL was 0.89-0.91 with the 15D, 0.85-0.87 with the EQ-5D, 68-80 with the EQ-5D-VAS, and 68-79 for global health status during curative treatment phases, with improvements in the remission phase (disease-free >18 months). In the remission phase, mean EQ-5D and 15D scores were similar to the general population. HRQoL remained stable during first- to later-line treatments, when the aim was no longer cure, and declined notably when tumour-controlling therapy was no longer meaningful. The symptom burden affecting mCRC survivors' well-being included insomnia, impotence, urinary frequency, and fatigue. Symptom burden was lower after treatment and slightly higher, though stable, through all phases of systemic therapy. HRQoL was high in curative treatment phases, further emphasizing the strategy of metastasectomy in mCRC when clinically meaningful.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

metastatic colorectal cancer
metastasectomy
local ablative therapy
health-related quality of life
QLQ-C30
EQ-5D
15D
QLQ-CR29
systemic therapy
chemotherapy

Publication and Content Type

ref (subject category)
art (subject category)

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