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Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species

Petersen, Anders Ø. (author)
Department of Health Technology, Technical University of Denmark, Lyngby, Denmark
Julienne, Hanna (author)
Department of Computational Biology-USR 3756 CNRS, Institut Pasteur, Paris, France
Hyötyläinen, Tuulia, 1971- (author)
Örebro universitet,Institutionen för naturvetenskap och teknik
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Sen, Partho (author)
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
Fan, Yong (author)
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Pedersen, Helle Krogh (author)
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Clinical Microbiomics A/S, Copenhagen, Denmark
Jäntti, Sirkku (author)
Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
Hansen, Tue H. (author)
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Nielsen, Trine (author)
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Jørgensen, Torben (author)
Department of Public Health, Faculty of Health and Medical Sciences , University of Copenhagen, Copenhagen, Denmark; Faculty of Medicine, Aalborg University, Aalborg East, Denmark
Hansen, Torben (author)
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Myers, Pernille Neve (author)
Department of Health Technology, Technical University of Denmark, Lyngby, Denmark
Nielsen, H. Bjørn (author)
Clinical Microbiomics A/S, Copenhagen, Denmark
Ehrlich, S. Dusko (author)
Department of Computational Biology-USR 3756 CNRS, Institut Pasteur, Paris, France
Oresic, Matej, 1967- (author)
Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
Pedersen, Oluf (author)
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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 (creator_code:org_t)
2021-06-24
2021
English.
In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 11:1
Related links:
https://doi.org/10.1...
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https://www.nature.c...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Knowledge about in vivo effects of human circulating C-6 hydroxylated bile acids (BAs), also called muricholic acids, is sparse. It is unsettled if the gut microbiome might contribute to their biosynthesis. Here, we measured a range of serum BAs and related them to markers of human metabolic health and the gut microbiome. We examined 283 non-obese and obese Danish adults from the MetaHit study. Fasting concentrations of serum BAs were quantified using ultra-performance liquid chromatography-tandem mass-spectrometry. The gut microbiome was characterized with shotgun metagenomic sequencing and genome-scale metabolic modeling. We find that tauro- and glycohyocholic acid correlated inversely with body mass index (P = 4.1e-03, P = 1.9e-05, respectively), waist circumference (P = 0.017, P = 1.1e-04, respectively), body fat percentage (P = 2.5e-03, P = 2.3e-06, respectively), insulin resistance (P = 0.051, P = 4.6e-4, respectively), fasting concentrations of triglycerides (P = 0.06, P = 9.2e-4, respectively) and leptin (P = 0.067, P = 9.2e-4). Tauro- and glycohyocholic acids, and tauro-a-muricholic acid were directly linked with a distinct gut microbial community primarily composed of Clostridia species (P = 0.037, P = 0.013, P = 0.027, respectively). We conclude that serum conjugated C-6-hydroxylated BAs associate with measures of human metabolic health and gut communities of Clostridia species. The findings merit preclinical interventions and human feasibility studies to explore the therapeutic potential of these BAs in obesity and type 2 diabetes.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

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