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Sökning: onr:"swepub:oai:DiVA.org:uu-428342" > Neutrophil Gelatina...

Neutrophil Gelatinase-Associated Lipocalin Measured on Clinical Laboratory Platforms for the Prediction of Acute Kidney Injury and the Associated Need for Dialysis Therapy : A Systematic Review and Meta-analysis

Albert, Christian (författare)
Otto von Guericke Univ, Univ Clin Cardiol & Angiol, Med Fac, Magdeburg, Germany.;Diaverum Renal Serv Germany, MVZ Neuen Garten 11, D-14469 Potsdam, Germany.
Zapf, Antonia (författare)
Univ Med Ctr Hamburg Eppendorf, Dept Med Biometry & Epidemiol, Hamburg, Germany.
Haase, Michael (författare)
Otto von Guericke Univ, Fac Med, Magdeburg, Germany.;Diaverum Renal Serv Germany, MVZ Neuen Garten 11, D-14469 Potsdam, Germany.
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Rover, Christian (författare)
Univ Med Ctr Gottingen, Dept Med Stat, Gottingen, Germany.
Pickering, John W. (författare)
Univ Otago Christchurch, Dept Med, Christchurch, New Zealand.;Christchurch Hosp, Emergency Dept, Christchurch, New Zealand.
Albert, Annemarie (författare)
Diaverum Renal Serv Germany, MVZ Neuen Garten 11, D-14469 Potsdam, Germany.;Klinikum Ernst von Bergmann, Dept Nephrol & Endocrinol, Potsdam, Germany.
Bellomo, Rinaldo (författare)
Austin Hosp, Dept Intens Care, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Integrated Crit Care, Melbourne, Vic, Australia.
Breidthardt, Tobias (författare)
Univ Hosp Basel, Dept Internal Med, Basel, Switzerland.;Univ Hosp Basel, Dept Nephrol, Basel, Switzerland.;Univ Hosp Basel, Dept Cardiol, Basel, Switzerland.
Camou, Fabrice (författare)
CHU Bordeaux, Hop St Andre, Serv Reanimat Med, Bordeaux, France.
Chen, Zhongquing (författare)
Southern Med Univ, Nanfang Hosp, Dept Crit Care Med, Guangzhou, Guangdong, Peoples R China.
Chocron, Sidney (författare)
Univ Hosp Jean Minjoz, Dept Thorac & Cardiovasc Surg, Besancon, France.
Cruz, Dinna (författare)
Univ Calif San Diego, Div Nephrol Hypertens, San Diego, CA 92103 USA.
de Geus, Hilde R. H. (författare)
Erasmus MC, Dept Intens Care, Rotterdam, Netherlands.
Devarajan, Prasad (författare)
Univ Cincinnati, Div Nephrol & Hypertens, Cincinnati Childrens Hosp, Cincinnati, OH USA.
Di Somma, Salvatore (författare)
Univ Rome, Dept Med Surg Sci & Translat Med, Emergency Med, S Andrea Hosp, Rome, Italy.
Doi, Kent (författare)
Univ Tokyo, Dept Emergency & Crit Care Med, Tokyo, Japan.
Endre, Zoltan H. (författare)
Univ New South Wales, Prince Wales Hosp, Dept Nephrol, Sydney, NSW, Australia.;Univ New South Wales, Clin Sch, Dept Nephrol, Sydney, NSW, Australia.
Garcia-Alvarez, Mercedes (författare)
Hosp Santa Creu Sant & Pau, Dept Anesthesiol, Barcelona, Spain.
Hjortrup, Peter B. (författare)
Copenhagen Univ Hosp, Dept Intens Care, Copenhagen, Denmark.
Hur, Mina (författare)
Konkuk Univ, Dept Lab Med, Sch Med, Seoul, South Korea.
Karaolanis, Georgios (författare)
Natl & Kapodistrian Univ Athens, Med Sch, Laiko Gen Hosp, Vasc Unit,Dept Surg 1, Athens, Greece.
Kavalci, Cemil (författare)
Baskent Univ, Emergency Dept, Fac Med, Ankara, Turkey.
Kim, Hanah (författare)
Konkuk Univ, Dept Lab Med, Sch Med, Seoul, South Korea.
Lentini, Paolo (författare)
San Bassiano Hosp, Dept Nephrol & Dialysis, Bassano Del Grappa, Italy.
Liebetrau, Christoph (författare)
Kerckhoff Clin, Dept Cardiol, Bad Nauheim, Germany.
Lipcsey, Miklós (författare)
Uppsala universitet,Anestesiologi och intensivvård
Martensson, Johan (författare)
Karolinska Institutet
Mueller, Christian (författare)
Univ Hosp Basel, Dept Internal Med, Basel, Switzerland.;Univ Hosp Basel, Dept Nephrol, Basel, Switzerland.;Univ Hosp Basel, Dept Cardiol, Basel, Switzerland.
Nanas, Serafim (författare)
Natl & Kapodistrian Univ Athens, Evangelismos Gen Hosp, Crit Care Dept 1, Athens, Greece.
Nickolas, Thomas L. (författare)
Columbia Univ, Vagelos Coll Phys & Surg, New York, NY USA.
Pipili, Chrysoula (författare)
Natl & Kapodistrian Univ Athens, Evangelismos Gen Hosp, Crit Care Dept 1, Athens, Greece.
Ronco, Claudio (författare)
Univ Padua, Nephrol Dialysis & Transplantat, Padua, Italy.;San Bortolo Hosp, Int Renal Res Inst, Vicenza, Italy.
Rosa-Diez, Guillermo J. (författare)
Hosp Italiano Buenos Aires, Dept Nephrol Dialysis & Transplantat, Buenos Aires, DF, Argentina.
Ralib, Azrina (författare)
Int Islamic Univ Malaysia, Dept Anaesthesiol & Intens Care, Pahang, Malaysia.
Soto, Karina (författare)
Hosp Fernando Fonseca, Dept Nephrol, Amadora, Portugal.;Univ Lisbon, Ctr Estat & Aplicacoes, CEAUL, Lisbon, Portugal.
Braun-Dullaeus, Ruediger C. (författare)
Otto von Guericke Univ, Univ Clin Cardiol & Angiol, Med Fac, Magdeburg, Germany.
Heinz, Judith (författare)
Univ Med Ctr Gottingen, Dept Med Stat, Gottingen, Germany.
Haase-Fielitz, Anja (författare)
Univ Potsdam, Brandenburg Med Sch Theodor Fontane, Immanuel Diakonie Bernau, Heart Ctr Brandenburg,Dept Cardiol,Fac Hlth Sci, Potsdam, Germany.
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Otto von Guericke Univ, Univ Clin Cardiol & Angiol, Med Fac, Magdeburg, Germany;Diaverum Renal Serv Germany, MVZ Neuen Garten 11, D-14469 Potsdam, Germany. Univ Med Ctr Hamburg Eppendorf, Dept Med Biometry & Epidemiol, Hamburg, Germany. (creator_code:org_t)
Elsevier BV, 2020
2020
Engelska.
Ingår i: American Journal of Kidney Diseases. - : Elsevier BV. - 0272-6386 .- 1523-6838. ; 76:6, s. 826-
Relaterad länk:
https://www.ncbi.nlm...
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https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
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  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
Stäng  
  • Rationale & Objective: The usefulness of measures of neutrophil gelatinase-associated lipocalin (NGAL) in urine or plasma obtained on clinical laboratory platforms for predicting acute kidney injury (AKI) and AKI requiring dialysis (AKI-D) has not been fully evaluated. We sought to quantitatively summarize published data to evaluate the value of urinary and plasma NGAL for kidney risk prediction.Study Design: Literature-based meta-analysis and individual-study-data meta-analysis of diagnostic studies following PRISMA-IPD guidelines.Setting & Study Populations: Studies of adults investigating AKI, severe AKI, and AKI-D in the setting of cardiac surgery, intensive care, or emergency department care using either urinary or plasma NGAL measured on clinical laboratory platforms.Selection Criteria for Studies: PubMed, Web of Science, Cochrane Library, Scopus, and congress abstracts ever published through February 2020 reporting diagnostic test studies of NGAL measured on clinical laboratory platforms to predict AKI.Data Extraction: Individual-study-data meta analysis was accomplished by giving authors data specifications tailored to their studies and requesting standardized patient-level data analysis.Analytical Approach: Individual-study-data meta analysis used a bivariate time-to-event model for interval-censored data from which discriminative ability (AUC) was characterized. NGAL cutoff concentrations at 95% sensitivity, 95% specificity, and optimal sensitivity and specificity were also estimated. Models incorporated as confounders the clinical setting and use versus nonuse of urine output as a criterion for AKI. A literature-based meta-analysis was also performed for all published studies including those for which the authors were unable to provide individual-study data analyses.Results: We included 52 observational studies involving 13,040 patients. We analyzed 30 data sets for the individual-study-data meta-analysis. For AKI, severe AKI, and AKI-D, numbers of events were 837, 304, and 103 for analyses of urinary NGAL, respectively; these values were 705, 271, and 178 for analyses of plasma NGAL. Discriminative performance was similar in both meta-analyses. Individual-study-data meta-analysis AUCs for urinary NGAL were 0.75 (95% CI, 0.73-0.76) and 0.80 (95% CI, 0.79-0.81) for severe AKI and AKI-D, respectively; for plasma NGAL, the corresponding AUCs were 0.80 (95% CI, 0.790.81) and 0.86 (95% CI, 0.84-0.8 6). Cutoff concentrations at 95% specificity for urinary NGAL were >580 ng/mL with 27% sensitivity for severe AKI and >589 ng/mL with 24% sensitivity for AKI-D. Corresponding cutoffs for plasma NGAL were >364 ng/mL with 44% sensitivity and >546 ng/mL with 26% sensitivity, respectively.Limitations: Practice variability in initiation of dialysis. Imperfect harmonization of data across studies. Conclusions: Urinary and plasma NGAL concentrations may identify patients at high risk for AKI in clinical research and practice. The cutoff concentrations reported in this study require prospective evaluation.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

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