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A Naturalistic Para...
A Naturalistic Paradigm to Investigate Postencoding Neural Activation Patterns in Relation to Subsequent Voluntary and Intrusive Recall of Distressing Events
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- Visser, Renee M. (författare)
- Univ Amsterdam, Dept Clin Psychol, Amsterdam, Netherlands.
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- Henson, Richard N. (författare)
- Univ Cambridge, Med Res Council Cognit & Brain Sci Unit, Cambridge, Cambridgeshire, England.;Univ Cambridge, Dept Psychiat, Cambridge, Cambridgeshire, England.
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- Holmes, Emily A. (författare)
- Karolinska Institutet,Uppsala universitet,Institutionen för psykologi,Karolinska Inst, Dept Clin Neurosci EAH, Stockholm, Sweden.
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Univ Amsterdam, Dept Clin Psychol, Amsterdam, Netherlands Univ Cambridge, Med Res Council Cognit & Brain Sci Unit, Cambridge, Cambridgeshire, England.;Univ Cambridge, Dept Psychiat, Cambridge, Cambridgeshire, England. (creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: Biological Psychiatry. - : Elsevier. - 2451-9022 .- 2451-9030. ; 7:10, s. 960-969
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Abstract
Ämnesord
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- BACKGROUND: While neuroimaging has provided insights into the formation of episodic memories in relation to voluntary memory recall, less is known about neural mechanisms that cause memories to occur involuntarily, for example, as intrusive memories of trauma. Here, we investigated brain activity shortly after viewing distressing events as a function of whether memories for those events later intruded involuntarily. The postencoding period is particularly important because it is a period when clinical interventions could be applied. METHODS: A total of 32 healthy volunteers underwent functional magnetic resonance imaging while viewing distressing film clips, interspersed with 5 minutes of awake (postencoding) rest. Voluntary memories of the films were assessed using free recall and verbal and visual recognition tests after a week, while intrusive (involuntary) memories were recorded in a diary throughout that week. RESULTS: When analyzing functional magnetic resonance imaging responses related to watching the films, we replicated findings that those "hotspots " (salient moments within the films) that would later become intrusive memories elicited higher activation in parts of the brain's salience network. Surprisingly, while the postencoding persistence of multivoxel correlation structures associated with entire film clips predicted subsequent voluntary recall, there was no evidence that they predicted subsequent intrusions. CONCLUSIONS: Results replicate findings regarding the formation of intrusive memories during encoding and extend findings regarding the consolidation of information in postencoding rest in relation to voluntary memory. While we provided a first step using a naturalistic paradigm, further research is needed to elucidate the role of postencoding neural processes in the development of intrusive memories.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
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