Characteristics and Outcomes of Patients with Cerebral Venous Sinus Thrombosis in SARS-CoV-2 Vaccine-Induced Immune Thrombotic Thrombocytopenia

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Characteristics and Outcomes of Patients with Cerebral Venous Sinus Thrombosis in SARS-CoV-2 Vaccine-Induced Immune Thrombotic Thrombocytopenia

Sánchez Van Kammen, Mayte (författare): Department of Neurology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands

Aguiar De Sousa, Diana (författare): Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Universitario Lisboa Norte, University of Lisbon, Lisbon, Portugal

Poli, Sven (författare): Department of Neurology and Stroke, Eberhard-Karls University, Tuebingen, Germany; Hertie Institute for Clinical Brain Research, Eberhard-Karls University, Tuebingen, Germany

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Cordonnier, Charlotte (författare): Department of Neurosciences and Cognition, Lille University Hospital, Lille, France

Heldner, Mirjam R. (författare): Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

Van De Munckhof, Anita (författare): Department of Neurology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands

Krzywicka, Katarzyna (författare): Department of Neurology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands

Van Haaps, Thijs (författare): Department of Internal Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands

Ciccone, Alfonso (författare): Department of Neurology, Carlo Poma Hospital, Azienda Socio Sanitaria Territoriale di Mantova, Mantua, Italy

Middeldorp, Saskia (författare): Department of Internal Medicine, Radboud Institute of Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands

Levi, Marcel M. (författare): National Institute for Health Research, University College London Hospitals, Biomedical Research Centre, London, United Kingdom

Kremer Hovinga, Johanna A. (författare): Department of Hematology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

Silvis, Suzanne (författare): Department of Neurology, Albert Schweitzer Hospital, Dordrecht, Netherlands

Hiltunen, Sini (författare): Department of Neurology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland

Mansour, Maryam (författare): Sina Hospital, Hamadan University of Medical Science, Hamadan, Iran

Arauz, Antonio (författare): National Institute of Neurology and Neurosurgery Manuel Velasco Suarez, Mexico City, Mexico

Barboza, Miguel A. (författare): Neurosciences Department, Hospital Dr R.A. Calderón Guardia, San José, Costa Rica

Field, Thalia S. (författare): Division of Neurology, University of British Columbia, Vancouver Stroke Program, BC, Vancouver, Canada

Tsivgoulis, Georgios (författare): Second Department of Neurology in National, Kapodistrian University of Athens, School of Medicine, Athens, Greece

Nagel, Simon (författare): Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany

Lindgren, Erik, 1993 (författare): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience

Tatlisumak, Turgut (författare): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience

Jood, Katarina, 1966 (författare): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience

Putaala, Jukka (författare): Department of Neurology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland

Ferro, Jose M. (författare): Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Universitario Lisboa Norte, University of Lisbon, Lisbon, Portugal

Arnold, Marcel (författare): Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

Coutinho, Jonathan M. (författare): Department of Neurology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands

Sharma, Aarti R. (författare): Imperial College London School of Medicine, Imperial College London, London, United Kingdom

Elkady, Ahmed (författare): Department of Neurology, Saudi German Hospital, Jeddah, Saudi Arabia

Negro, Alberto (författare): Department of Neuroradiology, Ospedale Del Mare, Naples, Italy

Günther, Albrecht (författare): Department of Neurology, Jena University Hospital, Jena, Germany

Gutschalk, Alexander (författare): Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany

Schönenberger, Silvia (författare): Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany

Buture, Alina (författare): Acute Stroke Service, Mater Misericordiae University Hospital, Dublin, Ireland

Murphy, Sean (författare): Acute Stroke Service, Mater Misericordiae University Hospital, Dublin, Ireland; UCD School of Medicine, University College Dublin, Dublin, Ireland; School of Medicine, University of Medicine and Health Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland

Paiva Nunes, Ana (författare): Department of Neurology, Centro Hospitalar de Lisboa Central, Lisbon, Portugal

Tiede, Andreas (författare): Clinic for Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany

Puthuppallil Philip, Anemon (författare): Department of Neurology, Hamilton General Hospital, ON, Hamilton, Canada

Mengel, Annerose (författare): Department of Neurology and Stroke, University Hospital Tuebingen, Tuebingen, Germany

Medina, Antonio (författare): Department of Neurology, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain

Hellström Vogel, Åslög (författare): Department of Internal Medicine, Skåne University Hospital, Lund, Sweden

Tawa, Audrey (författare): Department of Anesthesia and Intensive Care, University Hospital of Rennes, Rennes, France

Aujayeb, Avinash (författare): Respiratory Department, Northumbria Healthcare NHS Foundation Trust, Cramlington, United Kingdom

Casolla, Barbara (författare): Respiratory Department, Northumbria Healthcare NHS Foundation Trust, Cramlington, United Kingdom; Stroke Unit, Hôpital Pasteur 2, URRIS - UR2CA, Unité de Recherche Clinique Cote d'Azur, Cote d'Azur University, Nice, France

Buck, Brian (författare): Division of Neurology, University of Alberta Hospital, AL, Edmonton, Canada

Zanferrari, Carla (författare): Department of Neurology, Azienda Ospedaliera di Melegnano e della Martesana, Melegnano, Italy

Garcia-Esperon, Carlos (författare): Department of Neurology, John Hunter Hospital, Newcastle, Australia

Vayne, Caroline (författare): Department of Hematology and Hemostasis, Tours University Hospital, Tours, France

Legault, Catherine (författare): Department of Neurology and Neurosurgery, McGill University Health Centre, QC, Montreal, Canada

Pfrepper, Christian (författare): Division of Hemostaseology, Leipzig University Hospital, Leipzig, Germany

Tracol, Clement (författare): Department of Neurology, CHU Rennes, Rennes, France

Soriano, Cristina (författare): Department of Neurology, Hospital General de Castellón, Castelló, Spain

Guisado-Alonso, Daniel (författare): Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

Bougon, David (författare): Department of Critical Care, Annecy Genevois Hospital, Annecy, France

Zimatore, Domenico S. (författare): Department of Neuroradiology, Policlinico di Bari, Bari, Italy

Michalski, Dominik (författare): Department of Neurology, Leipzig University Hospital, Leipzig, Germany

Blacquiere, Dylan (författare): Division of Neurology, Ottawa Hospital, ON, Ottawa, Canada

Johansson, Elias (författare): Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Neurovetenskaper

Cuadrado-Godia, Elisa (författare): Department of Neurology, University Hospital Del Mar, Barcelona, Spain

De Maistre, Emmanuel (författare): Department of Biological Haematology, CHU Dijon, Dijon, France

Carrera, Emmanuel (författare): Department of Neurology, Hôpitaux Universitaires de Genève, Geneva, Switzerland

Vuillier, Fabrice (författare): Stroke Unit, University Hospital of Besancon, Besancon, France

Bonneville, Fabrice (författare): Department of Neuroradiology, Toulouse University Hospital, Toulouse, France

Giammello, Fabrizio (författare): Translational Molecular Medicine and Surgery, XXXV Cycle, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy

Bode, Felix J. (författare): Department of Neurology, Universitätsklinikum Bonn, Bonn, Germany

Zimmerman, Julian (författare): Department of Neurology, Universitätsklinikum Bonn, Bonn, Germany

D'Onofrio, Florindo (författare): Department of Neurology, San Giuseppe Moscati Hospital, Avellino, Italy

Grillo, Francesco (författare): Stroke Unit, Department of Clinical and Experimental Medicine, University Hospital G. Martino, Messina, Italy

Cotton, Francois (författare): Department of Radiology, Lyon University Hospital, Lyon, France

Caparros, François (författare): Department of Neurosciences and Cognition, Lille University Hospital, Lille, France

Puy, Laurent (författare): Department of Neurosciences and Cognition, Lille University Hospital, Lille, France

Maier, Frank (författare): Department of Neurology, Caritas Hospital Saarbrücken, Saarbrücken, Germany

Gulli, Giosue (författare): Department of Medicine, Ashford and St Peters Hospital NHS Foundation Trust, Surrey, United Kingdom

Frisullo, Giovanni (författare): Department of Neurology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy

Polkinghorne, Gregory (författare): Princess Alexandra Hospital, Brisbane, Australia

Franchineau, Guillaume (författare): Department of Intensive Care, Centre Hospitalier Intercommunal de Poissy Saint Germain en Laye, Poissy, France

Cangür, Hakan (författare): Department of Neurology, Hospital of the City of Wolfsburg, Wolfsburg, Germany

Katzberg, Hans (författare): Department of Neuromuscular Medicine, Toronto General Hospital, ON, Toronto, Canada

Sibon, Igor (författare): Department of Neurology, Bordeaux University Hospital, Bordeaux, France

Baharoglu, Irem (författare): Department of Neurology, Haga Hospital, The Hague, Netherlands

Brar, Jaskiran (författare): Department of Neurology, Surrey Memorial Hospital, BC, Surrey, Canada

Payen, Jean-François (författare): Department of Anesthesia and Critical Care, CHU Grenoble, Grenoble, France

Burrow, Jim (författare): Department of Neurology, Royal Darwin Hospital, Tiwi, Australia

Fernandes, João (författare): Department of Neurology, Norra Alvsborgs Länssjukhus, Trollhattan, Sweden

Schouten, Judith (författare): Department of Neurology, Rijnstate Hospital Arnhem, Arnhem, Netherlands

Althaus, Katharina (författare): Department of Neurology, Ulm University Hospital, Ulm, Germany

Garambois, Katia (författare): Stroke Unit, University Hospital of Grenoble, Grenoble, France

Derex, Laurent (författare): Department of Neurology, Hospices Civils de Lyon, Lyon, France

Humbertjean, Lisa (författare): Stroke Unit, University Hospital of Nancy, Nancy, France

Lebrato Hernandez, Lucia (författare): Department of Neurology, Virgen Del Rocio University Hospital, Seville, Spain

Kellermair, Lukas (författare): Department of Neurology, Johannes Kepler University Linz, Linz, Austria

Morin Martin, Mar (författare): Department of Neurology, Hospital Complex of Toledo, Toledo, Spain

Petruzzellis, Marco (författare): Department of Neurology, AOU Consorziale Policlinico di Bari, Bari, Italy

Cotelli, Maria (författare): Department of Neurology, ASL Vallecamonica-Sebino, Breno, Italy

Dubois, Marie-Cécile (författare): Department of Anesthesia and Intensive Care, University Hospital of Poitiers, Poitiers, France

Carvalho, Marta (författare): Department of Neurology, Centro Hospitalar Universitário de São João, Faculdade de Medicina, Universidade Do Porto, Porto, Portugal

Wittstock, Matthias (författare): Department of Neurology, University Hospital Rostock, Rostock, Germany

Miranda, Miguel (författare): Department of Neurology, Hospital de Cascais Dr José de Almeida, Cascais, Portugal

Skjelland, Mona (författare): Department of Neurology, Oslo University Hospital, Oslo, Norway

Bandettini Di Poggio, Monica (författare): Department of Neuroscience, Policlinic San Martino Hospital, Genoa, Italy

Scholz, Moritz J. (författare): Department of Neurology, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany

Raposo, Nicolas (författare): Department of Neurology, Toulouse University Hospital, Toulouse, France

Kahnis, Robert (författare): Department of Neurology, Toulouse University Hospital, Toulouse, France

Kruyt, Nyika (författare): Department of Neurology, Leiden University Medical Centre, Leiden, Netherlands

Huet, Olivier (författare): UFR de Bio-médecine, Hospital de la Cavale Blanche, CHRU de Brest, Brest, France

Sharma, Pankaj (författare): Institute of Cardiovascular Research, Royal Holloway University of London, London, United Kingdom

Candelaresi, Paolo (författare): Department of Neurology and Stroke, Cardarelli Hospital, Naples, Italy

Reiner, Peggy (författare): Department of Neurology, Lariboisière Hospital, Paris, France

Vieira, Ricardo (författare): Department of Hematology, Universidade Federal Do Cariri, Juazeiro do Norte, Brazil

Acampora, Roberto (författare): Department of Neurology, Ospedale Del Mare, Naples, Italy

Kern, Rolf (författare): Department of Neurology, Kempten Hospital, Kempten, Germany

Leker, Ronen (författare): Department of Neurology, Hadassah University Medical Center, Jerusalem, Israel

Coutts, Shelagh (författare): Department of Clinical Neurosciences, Radiology, and Community Health Sciences, Foothills Medical Centre, AL, Calgary, Canada

Bal, Simerpreet (författare): Department of Clinical Neurosciences, Radiology, and Community Health Sciences, Foothills Medical Centre, AL, Calgary, Canada

Sharma, Shyam S. (författare): Edinburgh Medical School, University of Edinburgh, Edinburgh, United Kingdom

Susen, Sophie (författare): Department of Hematology and Transfusion, Lille University Hospital, Lille, France

Cox, Thomas (författare): Department of Neurology, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom

Geeraerts, Thomas (författare): Department of Anesthesiology and Critical Care, Toulouse University Hospital, Toulouse, France

Gattringer, Thomas (författare): Department of Neurology, Medical University of Graz, Graz, Austria

Bartsch, Thorsten (författare): Department of Neurology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany

Kleinig, Timothy J. (författare): Department of Neurology, Royal Adelaide Hospital, Adelaide, Australia

Dizonno, Vanessa (författare): Division of Neurology, University of British Columbia, Vancouver Stroke Program, BC, Vancouver, Canada

Arslan, Yildiz (författare): Neurology Clinic, Medicana İzmir International Hospital, Izmir, Turkey

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(creator_code:org_t)

American Medical Association, 2021
2021
Engelska.
Ingår i: JAMA Neurology. - : American Medical Association. - 2168-6149 .- 2168-6157. ; 78:11, s. 1314-1323

Relaterad länk:: https://jamanetwork....; visa fler...; https://urn.kb.se/re...; https://doi.org/10.1...; https://gup.ub.gu.se...; visa färre...

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Importance: Thrombosis with thrombocytopenia syndrome (TTS) has been reported after vaccination with the SARS-CoV-2 vaccines ChAdOx1 nCov-19 (Oxford-AstraZeneca) and Ad26.COV2.S (Janssen/Johnson & Johnson).Objective: To describe the clinical characteristics and outcome of patients with cerebral venous sinus thrombosis (CVST) after SARS-CoV-2 vaccination with and without TTS.Design, Setting, and Participants: This cohort study used data from an international registry of consecutive patients with CVST within 28 days of SARS-CoV-2 vaccination included between March 29 and June 18, 2021, from 81 hospitals in 19 countries. For reference, data from patients with CVST between 2015 and 2018 were derived from an existing international registry. Clinical characteristics and mortality rate were described for adults with (1) CVST in the setting of SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia, (2) CVST after SARS-CoV-2 vaccination not fulling criteria for TTS, and (3) CVST unrelated to SARS-CoV-2 vaccination.Exposures: Patients were classified as having TTS if they had new-onset thrombocytopenia without recent exposure to heparin, in accordance with the Brighton Collaboration interim criteria.Main Outcomes and Measures: Clinical characteristics and mortality rate.Results: Of 116 patients with postvaccination CVST, 78 (67.2%) had TTS, of whom 76 had been vaccinated with ChAdOx1 nCov-19; 38 (32.8%) had no indication of TTS. The control group included 207 patients with CVST before the COVID-19 pandemic. A total of 63 of 78 (81%), 30 of 38 (79%), and 145 of 207 (70.0%) patients, respectively, were female, and the mean (SD) age was 45 (14), 55 (20), and 42 (16) years, respectively. Concomitant thromboembolism occurred in 25 of 70 patients (36%) in the TTS group, 2 of 35 (6%) in the no TTS group, and 10 of 206 (4.9%) in the control group, and in-hospital mortality rates were 47% (36 of 76; 95% CI, 37-58), 5% (2 of 37; 95% CI, 1-18), and 3.9% (8 of 207; 95% CI, 2.0-7.4), respectively. The mortality rate was 61% (14 of 23) among patients in the TTS group diagnosed before the condition garnered attention in the scientific community and 42% (22 of 53) among patients diagnosed later.Conclusions and Relevance: In this cohort study of patients with CVST, a distinct clinical profile and high mortality rate was observed in patients meeting criteria for TTS after SARS-CoV-2 vaccination..

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Av författaren/redakt...: Sánchez Van Kamm ...; Aguiar De Sousa, ...; Poli, Sven; Cordonnier, Char ...; Heldner, Mirjam ...; Van De Munckhof, ...; visa fler...; Krzywicka, Katar ...; Van Haaps, Thijs; Ciccone, Alfonso; Middeldorp, Sask ...; Levi, Marcel M.; Kremer Hovinga, ...; Silvis, Suzanne; Hiltunen, Sini; Mansour, Maryam; Arauz, Antonio; Barboza, Miguel ...; Field, Thalia S.; Tsivgoulis, Geor ...; Nagel, Simon; Lindgren, Erik, ...; Tatlisumak, Turg ...; Jood, Katarina, ...; Putaala, Jukka; Ferro, Jose M.; Arnold, Marcel; Coutinho, Jonath ...; Sharma, Aarti R.; Elkady, Ahmed; Negro, Alberto; Günther, Albrech ...; Gutschalk, Alexa ...; Schönenberger, S ...; Buture, Alina; Murphy, Sean; Paiva Nunes, Ana; Tiede, Andreas; Puthuppallil Phi ...; Mengel, Annerose; Medina, Antonio; Hellström Vogel, ...; Tawa, Audrey; Aujayeb, Avinash; Casolla, Barbara; Buck, Brian; Zanferrari, Carl ...; Garcia-Esperon, ...; Vayne, Caroline; Legault, Catheri ...; Pfrepper, Christ ...; Tracol, Clement; Soriano, Cristin ...; Guisado-Alonso, ...; Bougon, David; Zimatore, Domeni ...; Michalski, Domin ...; Blacquiere, Dyla ...; Johansson, Elias; Cuadrado-Godia, ...; De Maistre, Emma ...; Carrera, Emmanue ...; Vuillier, Fabric ...; Bonneville, Fabr ...; Giammello, Fabri ...; Bode, Felix J.; Zimmerman, Julia ...; D'Onofrio, Flori ...; Grillo, Francesc ...; Cotton, Francois; Caparros, Franço ...; Puy, Laurent; Maier, Frank; Gulli, Giosue; Frisullo, Giovan ...; Polkinghorne, Gr ...; Franchineau, Gui ...; Cangür, Hakan; Katzberg, Hans; Sibon, Igor; Baharoglu, Irem; Brar, Jaskiran; Payen, Jean-Fran ...; Burrow, Jim; Fernandes, João; Schouten, Judith; Althaus, Kathari ...; Garambois, Katia; Derex, Laurent; Humbertjean, Lis ...; Lebrato Hernande ...; Kellermair, Luka ...; Morin Martin, Ma ...; Petruzzellis, Ma ...; Cotelli, Maria; Dubois, Marie-Cé ...; Carvalho, Marta; Wittstock, Matth ...; Miranda, Miguel; Skjelland, Mona; Bandettini Di Po ...; Scholz, Moritz J ...; Raposo, Nicolas; Kahnis, Robert; Kruyt, Nyika; Huet, Olivier; Sharma, Pankaj; Candelaresi, Pao ...; Reiner, Peggy; Vieira, Ricardo; Acampora, Robert ...; Kern, Rolf; Leker, Ronen; Coutts, Shelagh; Bal, Simerpreet; Sharma, Shyam S.; Susen, Sophie; Cox, Thomas; Geeraerts, Thoma ...; Gattringer, Thom ...; Bartsch, Thorste ...; Kleinig, Timothy ...; Dizonno, Vanessa; Arslan, Yildiz; visa färre...

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Artiklar i publikationen: JAMA Neurology

Av lärosätet: Umeå universitet; Göteborgs universitet

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Characteristics and Outcomes of Patients with Cerebral Venous Sinus Thrombosis in SARS-CoV-2 Vaccine-Induced Immune Thrombotic Thrombocytopenia

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