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Pentraxin-3 vs C-re...
Pentraxin-3 vs C-reactive protein and other prognostic biomarkers in acute coronary syndrome : A substudy of the Platelet Inhibition and Patients Outcomes (PLATO) trial
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Kontny, Frederic (author)
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Andersen, Thomas (author)
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Ueland, Thor (author)
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- Åkerblom, Axel, 1977- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Ghukasyan Lakic, Tatevik (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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Michelsen, Annika E. (author)
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Aukrust, Pål (author)
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- Bertilsson, Maria (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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Becker, Richard C. (author)
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Himmelmann, Anders (author)
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- James, Stefan K., 1964- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Siegbahn, Agneta, 1947- (author)
- Uppsala universitet,Kardiologi,Klinisk kemi
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Storey, Robert F. (author)
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- Wallentin, Lars, 1943- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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(creator_code:org_t)
- 2019-04-24
- 2020
- English.
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In: European Heart Journal. - : Oxford University Press (OUP). - 2048-8726 .- 2048-8734. ; 9:4, s. 313-322
- Related links:
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https://munin.uit.no...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- AIMS: We investigated the dynamics, associations with patient characteristics, other biomarkers, and clinical outcomes of pentraxin 3 in acute coronary syndrome.METHODS AND RESULTS: In multivariate analyses, pentraxin 3 measured in 5154 patients randomised in the Platelet Inhibition and Patients Outcomes (PLATO) trial (NCT00391872) was compared with leukocytes, high-sensitivity C-reactive protein, interleukin-6, cystatin C, N-terminal prohormone brain natriuretic peptide, high-sensitivity troponin T and growth differentiation factor 15 concerning prediction of clinical outcome. Pentraxin 3 peaked earlier than high-sensitivity C-reactive protein and was more strongly correlated with N-terminal prohormone brain natriuretic peptide and high-sensitivity troponin T than with high-sensitivity C-reactive protein. The frequency of cardiovascular death, spontaneous myocardial infarction or stroke by quartiles of pentraxin 3 at admission was 6.1%, 7.3%, 9.7% and 10.7%, respectively ( p<0.0001). The hazard ratio per 50% increase of pentraxin 3 was 1.13 (95% confidence interval: 1.07-1.19), p<0.0001. This association remained significant after stepwise adjustments for leukocytes/high-sensitivity C-reactive protein (1.09 (1.02-1.15)), p=0.009, interleukin-6 (1.07 (1.01-1.14)), p=0.026, and cystatin C (1.07 (1.00-1.13)), p=0.044, but not after adjustment for N-terminal prohormone brain natriuretic peptide, high-sensitivity troponin T and growth differentiation factor 15. Admission pentraxin 3 was also associated with several of the individual endpoint components (cardiovascular death/spontaneous myocardial infarction; p=0.008, cardiovascular death; p=0.026, and spontaneous myocardial infarction; p=0.017), but not with stroke. Pentraxin 3 measured in the chronic phase (i.e. at one month) was still predictive of the composite endpoint in univariate analysis (1.12 (1.04-1.20) per 50% increase) p=0.0024, but not after adjustment for the other biomarkers.CONCLUSION: Admission level of pentraxin 3 is a modestly stronger predictor than high-sensitivity C-reactive protein and interleukin-6, but not than N-terminal prohormone brain natriuretic peptide or high-sensitivity troponin T, concerning cardiovascular outcome in acute coronary syndrome. Pentraxin 3 is more strongly correlated with N-terminal prohormone brain natriuretic peptide and high-sensitivity troponin T than with high-sensitivity C-reactive protein.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- C-reactive protein
- Pentraxin 3
- acute coronary syndrome
- adverse clinical outcome
- biomarkers
- prognosis
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kontny, Frederic
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Andersen, Thomas
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Ueland, Thor
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Åkerblom, Axel, ...
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Ghukasyan Lakic, ...
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Michelsen, Annik ...
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show more...
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Aukrust, Pål
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Bertilsson, Mari ...
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Becker, Richard ...
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Himmelmann, Ande ...
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James, Stefan K. ...
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Siegbahn, Agneta ...
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Storey, Robert F ...
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Wallentin, Lars, ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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European Heart J ...
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Uppsala University