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Sökning: onr:"swepub:oai:DiVA.org:umu-126378" > omega-3 Polyunsatur...

omega-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease Pooling Project of 19 Cohort Studies

Del Gobbo, Liana C. (författare)
Stanford University,Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA.
Imamura, Fumiaki (författare)
University of Cambridge,Univ Cambridge, Sch Clin Med, Epidemiol Unit, Med Res Council,Inst Metab Sci, Cambridge, England.
Aslibekyan, Stella (författare)
University of Alabama,Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL USA.
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Marklund, Matti (författare)
Uppsala universitet,Uppsala University,University of Washington,Florida International University,Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.,University of Minnesota,National University of Singapore,Klinisk nutrition och metabolism,Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.,Florida Int Univ, Benjamin Leon Ctr Geriatr Res & Educ, Miami, FL 33199 USA.,Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.,Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Natl Univ Singapore, Dept Med, Yong Loo Lin Sch Med, Singapore, Singapore.;Natl Univ Hlth Syst, Singapore, Singapore.
Virtanen, Jyrki K. (författare)
University of Eastern Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Joensuu, Finland.
Wennberg, Maria (författare)
Umeå University,Umeå universitet,Näringsforskning,Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
Yakoob, Mohammad Y. (författare)
Stanford University,Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA.
Chiuve, Stephanie E. (författare)
Harvard University,Brigham & Womens Hosp, Dept Med, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
dela Cruz, Luicito (författare)
Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.
Frazier-Wood, Alexis C. (författare)
Baylor College of Medicine,ARS, USDA, Childrens Nutr Res Ctr, Baylor Coll Med, Houston, TX USA.
Fretts, Amanda M. (författare)
Guallar, Eliseo (författare)
Johns Hopkins Bloomberg School of Public Health,Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
Matsumoto, Chisa (författare)
Brigham and Women's Hospital / Harvard Medical School,Tokyo Med Univ, Div Cardiol, Tokyo, Japan.;Brigham & Womens Hosp, Div Aging, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA USA.
Prem, Kiesha (författare)
National University of Singapore,Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.
Tanaka, Tosh (författare)
National Institute on Aging, United States,University of Minnesota,NIA, Translat Gerontol Branch, Bethesda, MD 20892 USA.,Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
Wu, Jason H. Y. (författare)
University of Sydney,Univ Sydney, George Inst Global Hlth, Sydney Med Sch, Sydney, NSW, Australia.
Zhou, Xia (författare)
University of Minnesota,Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
Helmer, Catherine (författare)
University of Bordeaux,Inst Sante Publ Epidemiol & Dev, Inst Natl Sante & Rech Med, Ctr Inst Natl Sante & Rech Med Epidemiol Biostat, Bordeaux, France.;Univ Bordeaux, Inst Sante Publ Epidemiol & Dev, Ctr Inst Natl Sante & Rech Med Epidemiol Biostat, Bordeaux, France.
Ingelsson, Erik (författare)
Uppsala universitet,Uppsala University,Molekylär epidemiologi,Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA.
Yuan, Jian-Min (författare)
University of Pittsburgh,Univ Pittsburgh, Div Canc Control & Populat Sci, Inst Canc, Pittsburgh, PA USA.;Univ Pittsburgh, Dept Epidemiol, Grad Sch Publ Hlth, Pittsburgh, PA 15261 USA.
Barberger-Gateau, Pascale (författare)
University of Bordeaux,Inst Sante Publ Epidemiol & Dev, Inst Natl Sante & Rech Med, Ctr Inst Natl Sante & Rech Med Epidemiol Biostat, Bordeaux, France.;Univ Bordeaux, Inst Sante Publ Epidemiol & Dev, Ctr Inst Natl Sante & Rech Med Epidemiol Biostat, Bordeaux, France.
Campos, Hannia (författare)
Harvard University,Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
Chaves, Paulo H. M. (författare)
Djousse, Luc (författare)
Brigham and Women's Hospital / Harvard Medical School,Brigham & Womens Hosp, Div Aging, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA USA.
Giles, Graham G. (författare)
Cancer Council Victoria
Gomez-Aracena, Jose (författare)
University of Malaga,Univ Malaga, Dept Prevent Med, Malaga, Spain.
Hodge, Allison M. (författare)
Hu, Frank B. (författare)
Brigham and Women's Hospital / Harvard Medical School,Harvard Med Sch, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.
Jansson, Jan-Håkan (författare)
Umeå University,Umeå universitet,Medicin
Johansson, Ingegerd (författare)
Umeå University,Umeå universitet,Institutionen för odontologi,Umea Univ, Dept Odontol, Umea, Sweden.
Khaw, Kay-Tee (författare)
University of Cambridge,Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
Koh, Woon-Puay (författare)
Duke–NUS Medical School,Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.;Duke NUS Grad Med Sch Singapore, Singapore, Singapore.
Lemaitre, Rozenn N. (författare)
University of Washington,Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.
Lind, Lars (författare)
Uppsala universitet,Uppsala University,Kardiovaskulär epidemiologi
Luben, Robert N. (författare)
University of Cambridge,Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
Rimm, Eric B. (författare)
Brigham and Women's Hospital / Harvard Medical School,Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard Med Sch, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.
Risérus, Ulf (författare)
Uppsala universitet,Uppsala University,Klinisk nutrition och metabolism
Samieri, Cecilia (författare)
University of Bordeaux,Inst Sante Publ Epidemiol & Dev, Inst Natl Sante & Rech Med, Ctr Inst Natl Sante & Rech Med Epidemiol Biostat, Bordeaux, France.;Univ Bordeaux, Inst Sante Publ Epidemiol & Dev, Ctr Inst Natl Sante & Rech Med Epidemiol Biostat, Bordeaux, France.
Franks, Paul W. (författare)
Lund University,Lunds universitet,Umeå universitet,Medicin,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.;Lund Univ, Dept Clin Sci, Genet & Mol Epidemiol Unit, Lund, Sweden.
Siscovick, David S. (författare)
New York Academy of Medicine,New York Acad Med, New York, NY USA.
Stampfer, Meir (författare)
Brigham and Women's Hospital / Harvard Medical School,Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard Med Sch, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.
Steffen, Lyn M. (författare)
Steffen, Brian T. (författare)
Tsai, Michael Y. (författare)
University of Minnesota,Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA.
van Dam, Rob M. (författare)
Voutilainen, Sari (författare)
University of Eastern Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Joensuu, Finland.
Willett, Walter C. (författare)
Brigham and Women's Hospital / Harvard Medical School,Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard Med Sch, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.
Woodward, Mark (författare)
University of Oxford,Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.;Univ Sydney, George Inst Global Hlth, Sydney Med Sch, Sydney, NSW, Australia.;Univ Oxford, George Inst Global Hlth, Nuffield Dept Publ Hlth, Oxford, England.
Mozaffarian, Dariush (författare)
Tufts University,Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.
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Stanford University Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA (creator_code:org_t)
American Medical Association (AMA), 2016
2016
Engelska.
Ingår i: JAMA Internal Medicine. - : American Medical Association (AMA). - 2168-6106 .- 2168-6114. ; 176:8, s. 1155-1166
Relaterad länk:
https://jamanetwork....
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http://dx.doi.org/10...
https://urn.kb.se/re...
https://doi.org/10.1...
https://lup.lub.lu.s...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • IMPORTANCE The role of omega-3 polyunsaturated fatty acids for primary prevention of coronary heart disease (CHD) remains controversial. Most prior longitudinal studies evaluated self-reported consumption rather than biomarkers. OBJECTIVE To evaluate biomarkers of seafood-derived eicosapentaenoic acid (EPA; 20: 5 omega-3), docosapentaenoic acid (DPA; 22: 5 omega-3), and docosahexaenoic acid (DHA; 22: 6 omega-3) and plant-derived alpha-linolenic acid (ALA; 18: 3 omega-3) for incident CHD. DATA SOURCES A global consortium of 19 studies identified by November 2014. STUDY SELECTION Available prospective (cohort, nested case-control) or retrospective studies with circulating or tissue omega-3 biomarkers and ascertained CHD. DATA EXTRACTION AND SYNTHESIS Each study conducted standardized, individual-level analysis using harmonized models, exposures, outcomes, and covariates. Findings were centrally pooled using random-effects meta-analysis. Heterogeneity was examined by age, sex, race, diabetes, statins, aspirin, omega-6 levels, and FADS desaturase genes. MAIN OUTCOMES AND MEASURES Incident total CHD, fatal CHD, and nonfatal myocardial infarction (MI). RESULTS The 19 studies comprised 16 countries, 45 637 unique individuals, and 7973 total CHD, 2781 fatal CHD, and 7157 nonfatal MI events, with omega-3 measures in total plasma, phospholipids, cholesterol esters, and adipose tissue. Median age at baseline was 59 years (range, 18-97 years), and 28 660 (62.8%) were male. In continuous (per 1-SD increase) multivariable-adjusted analyses, the omega-3 biomarkers ALA, DPA, and DHA were associated with a lower risk of fatal CHD, with relative risks (RRs) of 0.91 (95% CI, 0.84-0.98) for ALA, 0.90 (95% CI, 0.85-0.96) for DPA, and 0.90 (95% CI, 0.84-0.96) for DHA. Although DPA was associated with a lower risk of total CHD (RR, 0.94; 95% CI, 0.90-0.99), ALA (RR, 1.00; 95% CI, 0.95-1.05), EPA (RR, 0.94; 95% CI, 0.87-1.02), and DHA (RR, 0.95; 95% CI, 0.91-1.00) were not. Significant associations with nonfatal MI were not evident. Associations appeared generally stronger in phospholipids and total plasma. Restricted cubic splines did not identify evidence of nonlinearity in dose responses. CONCLUSIONS AND RELEVANCE On the basis of available studies of free-living populations globally, biomarker concentrations of seafood and plant-derived omega-3 fatty acids are associated with a modestly lower incidence of fatal CHD.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

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