Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies

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Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes : A pooled analysis of prospective cohort studies

Imamura, Fumiaki (författare): Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.

Fretts, Amanda M. (författare): Univ Washington, Dept Epidemiol, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.

Marklund, Matti (författare): Uppsala universitet,Klinisk nutrition och metabolism,Univ New South Wales, George Inst Global Hlth, Fac Med, Sydney, NSW, Australia.;Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.

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Ardisson Korat, Andres V. (författare): Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.

Yang, Wei-Sin (författare): Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Coll Publ Hlth, Taipei, Taiwan.

Lankinen, Maria (författare): Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.

Qureshi, Waqas (författare): Wake Forest Univ, Sch Med, Dept Internal Med, Sect Cardiovasc Med, Winston Salem, NC 27101 USA.

Helmer, Catherine (författare): Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France.

Chen, Tzu-An (författare): USDA ARS, Childrens Nutr Res Ctr, Dept Pediat, Baylor Coll Med, Houston, TX USA.

Virtanen, Jyrki K. (författare): Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.

Wong, Kerry (författare): Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.

Bassett, Julie K. (författare): Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.

Murphy, Rachel (författare): Univ British Columbia, Sch Populat Publ & Hlth, Ctr Excellence Canc Prevent, Fac Med, Vancouver, BC, Canada.

Tintle, Nathan (författare): Dordt Univ, Dept Math & Stat, Sioux Ctr, IA USA.

Yu, Chaoyu Ian (författare): Univ Washington, Sch Publ Hlth, Dept Biostat, Seattle, WA 98195 USA.

Brouwer, Ingeborg A. (författare): Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Hlth Sci, Fac Sci, Amsterdam, Netherlands.

Chien, Kuo-Liong (författare): Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Coll Publ Hlth, Taipei, Taiwan.;Taipei Vet Gen Hosp, Div Cardiol, Dept Med, Taipei, Taiwan.

Chen, Yun-yu (författare): Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Coll Publ Hlth, Taipei, Taiwan.;Taipei Vet Gen Hosp, Div Cardiol, Dept Med, Taipei, Taiwan.

Wood, Alexis C. (författare): USDA ARS, Childrens Nutr Res Ctr, Dept Pediat, Baylor Coll Med, Houston, TX USA.

del Gobbo, Liana C. (författare): Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA.

Djousse, Luc (författare): Harvard Med Sch, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Div Aging, 75 Francis St, Boston, MA 02115 USA.

Geleijnse, Johanna M. (författare): Wageningen Univ, Div Human Nutr & Hlth, Wageningen, Netherlands.

Giles, Graham G. (författare): Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Parkville, Vic, Australia.;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia.

de Goede, Janette (författare): Wageningen Univ, Div Human Nutr & Hlth, Wageningen, Netherlands.

Gudnason, Vilmundur (författare): Iceland Heart Assoc Res Inst, Kopavogur, Iceland.

Harris, William S. (författare): Univ South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD USA.;OmegaQuant Analyt, Sioux Falls, SD USA.

Hodge, Allison (författare): Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Parkville, Vic, Australia.

Hu, Frank (författare): Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.

Koulman, Albert (författare): Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.;Univ Cambridge, Natl Inst Hlth Res, Addenbrookes Hosp, Biomed Res Ctr,Core Nutr Biomarker Lab, Cambridge, England.;Univ Cambridge, Natl Inst Hlth Res, Addenbrookes Hosp, Biomed Res Ctr,Core Metabol & Lipid Lab, Cambridge, England.;MRC, Elsie Widdowson Lab, Cambridge, England.

Laakso, Markku (författare): Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland.;Kuopio Univ Hosp, Dept Med, Kuopio, Finland.

Lind, Lars (författare): Uppsala universitet,Klinisk epidemiologi

Lin, Hung-Ju (författare): Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan.

McKnight, Barbara (författare): Univ Washington, Sch Publ Hlth, Dept Biostat, Seattle, WA 98195 USA.

Rajaobelina, Kalina (författare): Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France.

Risérus, Ulf, 1967- (författare): Uppsala universitet,Klinisk nutrition och metabolism

Robinson, Jennifer G. (författare): Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Prevent Intervent Ctr, Iowa City, IA USA.

Samieri, Cecilia (författare): Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France.

Senn, Mackenzie (författare): USDA ARS, Childrens Nutr Res Ctr, Dept Pediat, Baylor Coll Med, Houston, TX USA.

Siscovick, David S. (författare): New York Acad Med, New York, NY USA.

Soedamah-Muthu, Sabita S. (författare): Wageningen Univ, Div Human Nutr & Hlth, Wageningen, Netherlands.;Tilburg Univ, Dept Med & Clin Psychol, Ctr Res Psychol & Somat Disorders, Tilburg, Netherlands.;Univ Reading, Inst Food Nutr & Hlth, Reading, Berks, England.

Sotoodehnia, Nona (författare): Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.

Sun, Qi (författare): Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.

Tsai, Michael Y. (författare): Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA.

Tuomainen, Tomi-Pekka (författare): Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.

Uusitupa, Matti (författare): Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.

Wagenknecht, Lynne E. (författare): Wake Forest Sch Med, Publ Hlth Sci, Winston Salem, NC 27101 USA.

Wareham, Nick J. (författare): Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.

Wu, Jason H. Y. (författare): Univ New South Wales, George Inst Global Hlth, Fac Med, Sydney, NSW, Australia.

Micha, Renata (författare): Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.

Lemaitre, Rozenn N. (författare): Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.

Mozaffarian, Dariush (författare): Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.

Forouhi, Nita G. (författare): Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.

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Univ Cambridge, MRC Epidemiol Unit, Cambridge, England Univ Washington, Dept Epidemiol, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA. (creator_code:org_t)

2020-06-12
2020
Engelska.
Ingår i: PLoS Medicine. - : Public Library of Science (PLoS). - 1549-1277 .- 1549-1676. ; 17:6

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://uu.diva-port... (primary) (Raw object); https://journals.plo...; https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

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BackgroundDe novo lipogenesis (DNL) is the primary metabolic pathway synthesizing fatty acids from carbohydrates, protein, or alcohol. Our aim was to examine associations of in vivo levels of selected fatty acids (16:0, 16:1n7, 18:0, 18:1n9) in DNL with incidence of type 2 diabetes (T2D).Methods and findingsSeventeen cohorts from 12 countries (7 from Europe, 7 from the United States, 1 from Australia, 1 from Taiwan; baseline years = 1970–1973 to 2006–2010) conducted harmonized individual-level analyses of associations of DNL-related fatty acids with incident T2D. In total, we evaluated 65,225 participants (mean ages = 52.3–75.5 years; % women = 20.4%–62.3% in 12 cohorts recruiting both sexes) and 15,383 incident cases of T2D over the 9-year follow-up on average. Cohort-specific association of each of 16:0, 16:1n7, 18:0, and 18:1n9 with incident T2D was estimated, adjusted for demographic factors, socioeconomic characteristics, alcohol, smoking, physical activity, dyslipidemia, hypertension, menopausal status, and adiposity. Cohort-specific associations were meta-analyzed with an inverse-variance-weighted approach. Each of the 4 fatty acids positively related to incident T2D. Relative risks (RRs) per cohort-specific range between midpoints of the top and bottom quintiles of fatty acid concentrations were 1.53 (1.41–1.66; p < 0.001) for 16:0, 1.40 (1.33–1.48; p < 0.001) for 16:1n-7, 1.14 (1.05–1.22; p = 0.001) for 18:0, and 1.16 (1.07–1.25; p < 0.001) for 18:1n9. Heterogeneity was seen across cohorts (I2 = 51.1%–73.1% for each fatty acid) but not explained by lipid fractions and global geographical regions. Further adjusted for triglycerides (and 16:0 when appropriate) to evaluate associations independent of overall DNL, the associations remained significant for 16:0, 16:1n7, and 18:0 but were attenuated for 18:1n9 (RR = 1.03, 95% confidence interval (CI) = 0.94–1.13). These findings had limitations in potential reverse causation and residual confounding by imprecisely measured or unmeasured factors.ConclusionsConcentrations of fatty acids in the DNL were positively associated with T2D incidence. Our findings support further work to investigate a possible role of DNL and individual fatty acids in the development of T2D.

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Av författaren/redakt...: Imamura, Fumiaki; Fretts, Amanda M ...; Marklund, Matti; Ardisson Korat, ...; Yang, Wei-Sin; Lankinen, Maria; visa fler...; Qureshi, Waqas; Helmer, Catherin ...; Chen, Tzu-An; Virtanen, Jyrki ...; Wong, Kerry; Bassett, Julie K ...; Murphy, Rachel; Tintle, Nathan; Yu, Chaoyu Ian; Brouwer, Ingebor ...; Chien, Kuo-Liong; Chen, Yun-yu; Wood, Alexis C.; del Gobbo, Liana ...; Djousse, Luc; Geleijnse, Johan ...; Giles, Graham G.; de Goede, Janett ...; Gudnason, Vilmun ...; Harris, William ...; Hodge, Allison; Hu, Frank; Koulman, Albert; Laakso, Markku; Lind, Lars; Lin, Hung-Ju; McKnight, Barbar ...; Rajaobelina, Kal ...; Risérus, Ulf, 19 ...; Robinson, Jennif ...; Samieri, Cecilia; Senn, Mackenzie; Siscovick, David ...; Soedamah-Muthu, ...; Sotoodehnia, Non ...; Sun, Qi; Tsai, Michael Y.; Tuomainen, Tomi- ...; Uusitupa, Matti; Wagenknecht, Lyn ...; Wareham, Nick J.; Wu, Jason H. Y.; Micha, Renata; Lemaitre, Rozenn ...; Mozaffarian, Dar ...; Forouhi, Nita G.; visa färre...

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Artiklar i publikationen: PLoS Medicine

Av lärosätet: Uppsala universitet

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Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes : A pooled analysis of prospective cohort studies

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