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Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

Artigas Soler, María (author)
Loth, Daan W (author)
Wain, Louise V (author)
show more...
Gharib, Sina A (author)
Obeidat, Ma'en (author)
Tang, Wenbo (author)
Zhai, Guangju (author)
Zhao, Jing Hua (author)
Smith, Albert Vernon (author)
Huffman, Jennifer E (author)
Albrecht, Eva (author)
Jackson, Catherine M (author)
Evans, David M (author)
Cadby, Gemma (author)
Fornage, Myriam (author)
Manichaikul, Ani (author)
Lopez, Lorna M (author)
Johnson, Toby (author)
Aldrich, Melinda C (author)
Aspelund, Thor (author)
Barroso, Inês (author)
Campbell, Harry (author)
Cassano, Patricia A (author)
Couper, David J (author)
Eiriksdottir, Gudny (author)
Franceschini, Nora (author)
Garcia, Melissa (author)
Gieger, Christian (author)
Gislason, Gauti Kjartan (author)
Grkovic, Ivica (author)
Hammond, Christopher J (author)
Hancock, Dana B (author)
Harris, Tamara B (author)
Ramasamy, Adaikalavan (author)
Heckbert, Susan R (author)
Heliövaara, Markku (author)
Homuth, Georg (author)
Hysi, Pirro G (author)
James, Alan L (author)
Jankovic, Stipan (author)
Joubert, Bonnie R (author)
Karrasch, Stefan (author)
Klopp, Norman (author)
Koch, Beate (author)
Kritchevsky, Stephen B (author)
Launer, Lenore J (author)
Liu, Yongmei (author)
Loehr, Laura R (author)
Lohman, Kurt (author)
Loos, Ruth J F (author)
Lumley, Thomas (author)
Al Balushi, Khalid A (author)
Ang, Wei Q (author)
Barr, R Graham (author)
Beilby, John (author)
Blakey, John D (author)
Boban, Mladen (author)
Boraska, Vesna (author)
Brisman, Jonas, 1954 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
Britton, John R (author)
Brusselle, Guy G (author)
Cooper, Cyrus (author)
Curjuric, Ivan (author)
Dahgam, Santosh (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
Deary, Ian J (author)
Ebrahim, Shah (author)
Eijgelsheim, Mark (author)
Francks, Clyde (author)
Gaysina, Darya (author)
Granell, Raquel (author)
Gu, Xiangjun (author)
Hankinson, John L (author)
Hardy, Rebecca (author)
Harris, Sarah E (author)
Henderson, John (author)
Henry, Amanda (author)
Hingorani, Aroon D (author)
Hofman, Albert (author)
Holt, Patrick G (author)
Hui, Jennie (author)
Hunter, Michael L (author)
Imboden, Medea (author)
Jameson, Karen A (author)
Kerr, Shona M (author)
Kolcic, Ivana (author)
Kronenberg, Florian (author)
Liu, Jason Z (author)
Marchini, Jonathan (author)
McKeever, Tricia (author)
Morris, Andrew D (author)
Olin, Anna-Carin, 1960 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
Porteous, David J (author)
Postma, Dirkje S (author)
Rich, Stephen S (author)
Ring, Susan M (author)
Rivadeneira, Fernando (author)
Rochat, Thierry (author)
Sayer, Avan Aihie (author)
Sayers, Ian (author)
Sly, Peter D (author)
Smith, George Davey (author)
Sood, Akshay (author)
Starr, John M (author)
Uitterlinden, André G (author)
Vonk, Judith M (author)
Wannamethee, S Goya (author)
Whincup, Peter H (author)
Wijmenga, Cisca (author)
Williams, O Dale (author)
Wong, Andrew (author)
Mangino, Massimo (author)
Marciante, Kristin D (author)
McArdle, Wendy L (author)
Meibohm, Bernd (author)
Morrison, Alanna C (author)
North, Kari E (author)
Omenaas, Ernst (author)
Palmer, Lyle J (author)
Pietiläinen, Kirsi H (author)
Pin, Isabelle (author)
Pola Sbreve Ek, Ozren (author)
Pouta, Anneli (author)
Psaty, Bruce M (author)
Hartikainen, Anna-Liisa (author)
Rantanen, Taina (author)
Ripatti, Samuli (author)
Rotter, Jerome I (author)
Rudan, Igor (author)
Rudnicka, Alicja R (author)
Schulz, Holger (author)
Shin, So-Youn (author)
Spector, Tim D (author)
Surakka, Ida (author)
Vitart, Veronique (author)
Völzke, Henry (author)
Wareham, Nicholas J (author)
Warrington, Nicole M (author)
Wichmann, H-Erich (author)
Wild, Sarah H (author)
Wilk, Jemma B (author)
Wjst, Matthias (author)
Wright, Alan F (author)
Zgaga, Lina (author)
Zemunik, Tatijana (author)
Pennell, Craig E (author)
Nyberg, Fredrik, 1961 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
Kuh, Diana (author)
Holloway, John W (author)
Boezen, H Marike (author)
Lawlor, Debbie A (author)
Morris, Richard W (author)
Probst-Hensch, Nicole (author)
Kaprio, Jaakko (author)
Wilson, James F (author)
Hayward, Caroline (author)
Kähönen, Mika (author)
Heinrich, Joachim (author)
Musk, Arthur W (author)
Jarvis, Deborah L (author)
Gläser, Sven (author)
Järvelin, Marjo-Riitta (author)
Ch Stricker, Bruno H (author)
Elliott, Paul (author)
O'Connor, George T (author)
Strachan, David P (author)
London, Stephanie J (author)
Hall, Ian P (author)
Gudnason, Vilmundur (author)
Tobin, Martin D (author)
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 (creator_code:org_t)
2011-09-25
2011
English.
In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:11, s. 1082-90
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

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By the author/editor
Artigas Soler, M ...
Loth, Daan W
Wain, Louise V
Gharib, Sina A
Obeidat, Ma'en
Tang, Wenbo
show more...
Zhai, Guangju
Zhao, Jing Hua
Smith, Albert Ve ...
Huffman, Jennife ...
Albrecht, Eva
Jackson, Catheri ...
Evans, David M
Cadby, Gemma
Fornage, Myriam
Manichaikul, Ani
Lopez, Lorna M
Johnson, Toby
Aldrich, Melinda ...
Aspelund, Thor
Barroso, Inês
Campbell, Harry
Cassano, Patrici ...
Couper, David J
Eiriksdottir, Gu ...
Franceschini, No ...
Garcia, Melissa
Gieger, Christia ...
Gislason, Gauti ...
Grkovic, Ivica
Hammond, Christo ...
Hancock, Dana B
Harris, Tamara B
Ramasamy, Adaika ...
Heckbert, Susan ...
Heliövaara, Mark ...
Homuth, Georg
Hysi, Pirro G
James, Alan L
Jankovic, Stipan
Joubert, Bonnie ...
Karrasch, Stefan
Klopp, Norman
Koch, Beate
Kritchevsky, Ste ...
Launer, Lenore J
Liu, Yongmei
Loehr, Laura R
Lohman, Kurt
Loos, Ruth J F
Lumley, Thomas
Al Balushi, Khal ...
Ang, Wei Q
Barr, R Graham
Beilby, John
Blakey, John D
Boban, Mladen
Boraska, Vesna
Brisman, Jonas, ...
Britton, John R
Brusselle, Guy G
Cooper, Cyrus
Curjuric, Ivan
Dahgam, Santosh
Deary, Ian J
Ebrahim, Shah
Eijgelsheim, Mar ...
Francks, Clyde
Gaysina, Darya
Granell, Raquel
Gu, Xiangjun
Hankinson, John ...
Hardy, Rebecca
Harris, Sarah E
Henderson, John
Henry, Amanda
Hingorani, Aroon ...
Hofman, Albert
Holt, Patrick G
Hui, Jennie
Hunter, Michael ...
Imboden, Medea
Jameson, Karen A
Kerr, Shona M
Kolcic, Ivana
Kronenberg, Flor ...
Liu, Jason Z
Marchini, Jonath ...
McKeever, Tricia
Morris, Andrew D
Olin, Anna-Carin ...
Porteous, David ...
Postma, Dirkje S
Rich, Stephen S
Ring, Susan M
Rivadeneira, Fer ...
Rochat, Thierry
Sayer, Avan Aihi ...
Sayers, Ian
Sly, Peter D
Smith, George Da ...
Sood, Akshay
Starr, John M
Uitterlinden, An ...
Vonk, Judith M
Wannamethee, S G ...
Whincup, Peter H
Wijmenga, Cisca
Williams, O Dale
Wong, Andrew
Mangino, Massimo
Marciante, Krist ...
McArdle, Wendy L
Meibohm, Bernd
Morrison, Alanna ...
North, Kari E
Omenaas, Ernst
Palmer, Lyle J
Pietiläinen, Kir ...
Pin, Isabelle
Pola Sbreve Ek, ...
Pouta, Anneli
Psaty, Bruce M
Hartikainen, Ann ...
Rantanen, Taina
Ripatti, Samuli
Rotter, Jerome I
Rudan, Igor
Rudnicka, Alicja ...
Schulz, Holger
Shin, So-Youn
Spector, Tim D
Surakka, Ida
Vitart, Veroniqu ...
Völzke, Henry
Wareham, Nichola ...
Warrington, Nico ...
Wichmann, H-Eric ...
Wild, Sarah H
Wilk, Jemma B
Wjst, Matthias
Wright, Alan F
Zgaga, Lina
Zemunik, Tatijan ...
Pennell, Craig E
Nyberg, Fredrik, ...
Kuh, Diana
Holloway, John W
Boezen, H Marike
Lawlor, Debbie A
Morris, Richard ...
Probst-Hensch, N ...
Kaprio, Jaakko
Wilson, James F
Hayward, Carolin ...
Kähönen, Mika
Heinrich, Joachi ...
Musk, Arthur W
Jarvis, Deborah ...
Gläser, Sven
Järvelin, Marjo- ...
Ch Stricker, Bru ...
Elliott, Paul
O'Connor, George ...
Strachan, David ...
London, Stephani ...
Hall, Ian P
Gudnason, Vilmun ...
Tobin, Martin D
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Health Sciences
and Public Health Gl ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Respiratory Medi ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
Articles in the publication
Nature genetics
By the university
University of Gothenburg

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