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Association of Lipi...
Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation : The AFGen Consortium
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- Norby, Faye L (author)
- University of Minnesota
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- Eryd, Samuel Adamsson (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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- Niemeijer, Maartje N (author)
- Erasmus University Rotterdam
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- Rose, Lynda M (author)
- Harvard University
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- Smith, Albert V (author)
- University of Iceland
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- Yin, Xiaoyan (author)
- Boston University
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- Agarwal, Sunil K (author)
- Icahn School of Medicine at Mount Sinai
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- Arking, Dan E (author)
- Johns Hopkins University
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- Chasman, Daniel L (author)
- Harvard University
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- Chen, Lin Y (author)
- University of Minnesota
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- Eijgelsheim, Mark (author)
- Erasmus University Rotterdam
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- Engström, Gunnar (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Franco, Oscar H (author)
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Heeringa, Jan (author)
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- Hindy, George (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Hofman, Albert (author)
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Lutsey, Pamela L (author)
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Magnani, Jared W (author)
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McManus, David D (author)
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Pankow, James S (author)
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- Rukh, Gull (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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- Schulz, Christina-Alexandra (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Uitterlinden, André G (author)
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Albert, Christine M (author)
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Benjamin, Emelia J (author)
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Gudnason, Vilmundur (author)
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- Smith, Gustav (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Institutionen för kliniska vetenskaper, Malmö,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Clinical Sciences, Malmö
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Stricker, Bruno H C (author)
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Alonso, Alvaro (author)
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(creator_code:org_t)
- 2016-03-21
- 2016
- English.
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In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:3
- Related links:
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http://dx.doi.org/10... (free)
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https://journals.plo...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: Several studies have shown associations between blood lipid levels and the risk of atrial fibrillation (AF). To test the potential effect of blood lipids with AF risk, we assessed whether previously developed lipid gene scores, used as instrumental variables, are associated with the incidence of AF in 7 large cohorts.METHODS: We analyzed 64,901 individuals of European ancestry without previous AF at baseline and with lipid gene scores. Lipid-specific gene scores, based on loci significantly associated with lipid levels, were calculated. Additionally, non-pleiotropic gene scores for high-density lipoprotein cholesterol (HDLc) and low-density lipoprotein cholesterol (LDLc) were calculated using SNPs that were only associated with the specific lipid fraction. Cox models were used to estimate the hazard ratio (HR) and 95% confidence intervals (CI) of AF per 1-standard deviation (SD) increase of each lipid gene score.RESULTS: During a mean follow-up of 12.0 years, 5434 (8.4%) incident AF cases were identified. After meta-analysis, the HDLc, LDLc, total cholesterol, and triglyceride gene scores were not associated with incidence of AF. Multivariable-adjusted HR (95% CI) were 1.01 (0.98-1.03); 0.98 (0.96-1.01); 0.98 (0.95-1.02); 0.99 (0.97-1.02), respectively. Similarly, non-pleiotropic HDLc and LDLc gene scores showed no association with incident AF: HR (95% CI) = 1.00 (0.97-1.03); 1.01 (0.99-1.04).CONCLUSIONS: In this large cohort study of individuals of European ancestry, gene scores for lipid fractions were not associated with incident AF.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Norby, Faye L
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Eryd, Samuel Ada ...
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Niemeijer, Maart ...
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Rose, Lynda M
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Smith, Albert V
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Yin, Xiaoyan
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show more...
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Agarwal, Sunil K
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Arking, Dan E
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Chasman, Daniel ...
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Chen, Lin Y
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Eijgelsheim, Mar ...
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Engström, Gunnar
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Franco, Oscar H
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Heeringa, Jan
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Hindy, George
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Hofman, Albert
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Lutsey, Pamela L
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Magnani, Jared W
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McManus, David D
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Orho-Melander, M ...
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Pankow, James S
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Rukh, Gull
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Schulz, Christin ...
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Uitterlinden, An ...
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Albert, Christin ...
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Benjamin, Emelia ...
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Gudnason, Vilmun ...
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Smith, Gustav
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Stricker, Bruno ...
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Alonso, Alvaro
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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PLoS ONE
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Lund University