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First reported nonp...
First reported nonpeptide AT1 receptor agonist (L-162,313) acts as an AT2 receptor agonist in vivo
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- Wan, Y. (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,OrgFarmKemi
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- Wallinder, Charlotta (author)
- Uppsala universitet,Institutionen för läkemedelskemi,OrgFarmKemi
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- Johansson, Berndt, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för gastroforskning,Institute of Surgical Sciences, Department of Gastro Research
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- Holm, Mathias, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för gastroforskning,Institute of Surgical Sciences, Department of Gastro Research
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- Karlén, Anders (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,OrgFarmKemi
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- Wu, X. (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,OrgFarmKemi
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- Botros, M. (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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Karlen, A. (author)
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- Pettersson, Anders, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för gastroforskning,Institute of Surgical Sciences, Department of Gastro Research
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- Nyberg, Fred (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Fändriks, Lars, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för gastroforskning,Institute of Surgical Sciences, Department of Gastro Research
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- Hallberg, Anders (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,OrgFarmKemi
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- Alterman, Mathias (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,OrgFarmKemi
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(creator_code:org_t)
- 2004-02-14
- 2004
- English.
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In: J Med Chem. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 47:6, s. 1536-1546
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- In this investigation, it is demonstrated that the first nonpeptide AT(1) receptor agonist L-162,313 (1), disclosed in 1994, also acts as an agonist at the AT(2) receptor. In anesthetized rats, administration of compound 1 intravenously or locally in the duodenum increased duodenal mucosal alkaline secretion, effects that were sensitive to the selective AT(2) receptor antagonist PD-123,319. The data strongly suggest that 1 is an AT(2) receptor agonist in vivo. To the best of our knowledge, this substance is the first nonpeptidic low-molecular weight compound with an agonistic effect mediated through the AT(2) receptor.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Angiotensin II Type 1 Receptor Blockers
- Animals
- Binding
- Competitive
- Biphenyl Compounds/*pharmacology
- Duodenum/drug effects/secretion
- Female
- Imidazoles/*pharmacology
- Intestinal Mucosa/drug effects/secretion
- Male
- Myometrium/metabolism
- Pyridines/Pharmacology
- Radioligand Assay
- Rats
- Rats
- Sprague-Dawley
- Receptor
- Angotnsin
- Type 1/agonists
- Receptor
- Angiotensin
- Type 2/*agonists/antagonists & inhibitors
- Swine
- Angiotensin II Type 1 Receptor Blockers
Publication and Content Type
- ref (subject category)
- art (subject category)
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J Med Chem
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To the university's database
- By the author/editor
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Wan, Y.
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Wallinder, Charl ...
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Johansson, Bernd ...
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Holm, Mathias, 1 ...
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Karlén, Anders
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Wu, X.
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Botros, M.
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Karlen, A.
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Pettersson, Ande ...
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Nyberg, Fred
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Fändriks, Lars, ...
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Hallberg, Anders
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Alterman, Mathia ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
- Articles in the publication
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J Med Chem
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Journal of Medic ...
- By the university
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University of Gothenburg
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Uppsala University