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An integrated cell atlas of the lung in health and disease

Sikkema, Lisa (författare)
Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; TUM School of Life Sciences, Technical University of Munich, Munich, Germany
Ramírez-Suástegui, Ciro (författare)
Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA, La Jolla
Strobl, Daniel C. (författare)
Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; Institute of Clinical Chemistry and Pathobiochemistry, TUM School of Medicine, Technical University of Munich, Munich, Germany
visa fler...
Gillett, Tessa E. (författare)
Experimental Pulmonary and Inflammatory Research, Department of Pathology and Medical Biology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
Zappia, Luke (författare)
Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; Department of Mathematics, Technical University of Munich, Garching, Germany
Madissoon, Elo (författare)
Wellcome Sanger Institute, Hinxton, Cambridge, UK, Cambridge
Markov, Nikolay S. (författare)
Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Zaragosi, Laure Emmanuelle (författare)
Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d’Azur and Centre National de la Recherche Scientifique, Valbonne, France
Ji, Yuge (författare)
Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; TUM School of Life Sciences, Technical University of Munich, Munich, Germany
Ansari, Meshal (författare)
Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany
Arguel, Marie Jeanne (författare)
Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d’Azur and Centre National de la Recherche Scientifique, Valbonne, France
Apperloo, Leonie (författare)
Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
Banchero, Martin (författare)
Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
Bécavin, Christophe (författare)
Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d’Azur and Centre National de la Recherche Scientifique, Valbonne, France
Berg, Marijn (författare)
Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
Chichelnitskiy, Evgeny (författare)
Institute for Transplant Immunology, Hannover Medical School, Hannover, Germany
Chung, Mei i. (författare)
Translational Genomics Research Institute, Phoenix, AZ, USA
Collin, Antoine (författare)
Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d’Azur and Centre National de la Recherche Scientifique, Valbonne, France; 3IA Côte d’Azur, Nice, France
Gay, Aurore C.A. (författare)
Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
Gote-Schniering, Janine (författare)
Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany
Hooshiar Kashani, Baharak (författare)
Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany
Inecik, Kemal (författare)
Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; TUM School of Life Sciences, Technical University of Munich, Munich, Germany
Jain, Manu (författare)
Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Kapellos, Theodore S. (författare)
Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany; Department of Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany
Kole, Tessa M. (författare)
Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
Leroy, Sylvie (författare)
Pulmonology Department, Fédération Hospitalo-Universitaire OncoAge, Centre Hospitalier Universitaire de Nice, Université Côte d’Azur, Nice, France
Mayr, Christoph H. (författare)
Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany
Oliver, Amanda J. (författare)
Wellcome Sanger Institute, Hinxton, Cambridge, UK, Cambridge
von Papen, Michael (författare)
Research, Development and Innovation, Comma Soft, Bonn, Germany
Peter, Lance (författare)
Translational Genomics Research Institute, Phoenix, AZ, USA
Taylor, Chase J. (författare)
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Walzthoeni, Thomas (författare)
Core Facility Genomics, Helmholtz Center Munich, Munich, Germany
Xu, Chuan (författare)
Wellcome Sanger Institute, Hinxton, Cambridge, UK, Cambridge
Bui, Linh T. (författare)
Translational Genomics Research Institute, Phoenix, AZ, USA
De Donno, Carlo (författare)
Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany
Dony, Leander (författare)
Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; TUM School of Life Sciences, Technical University of Munich, Munich, Germany; Department of Translational Psychiatry, Max Planck Institute of Psychiatry and International Max Planck Research School for Translational Psychiatry, Munich, Germany
Faiz, Alen (författare)
Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; School of Life Sciences, Respiratory Bioinformatics and Molecular Biology, University of Technology Sydney, Sydney, Australia
Guo, Minzhe (författare)
Division of Neonatology and Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, US
Gutierrez, Austin J. (författare)
Translational Genomics Research Institute, Phoenix, AZ, USA
Heumos, Lukas (författare)
Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; TUM School of Life Sciences, Technical University of Munich, Munich, Germany; Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany
Huang, Ni (författare)
Wellcome Sanger Institute, Hinxton, Cambridge, UK, Cambridge
Ibarra, Ignacio L. (författare)
Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany
Jackson, Nathan D. (författare)
Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA
Kadur Lakshminarasimha Murthy, Preetish (författare)
Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA; Department of Pharmacology and Regenerative Medicine, University of Illinois Chicago, Chicago, IL, USA
Lotfollahi, Mohammad (författare)
Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; Wellcome Sanger Institute, Hinxton, Cambridge, UK, Cambridge
Tabib, Tracy (författare)
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Talavera-López, Carlos (författare)
Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; Division of Infectious Diseases and Tropical Medicine, Klinikum der Lüdwig-Maximilians-Universität, Munich, Germany
Travaglini, Kyle J. (författare)
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA; Allen Institute for Brain Science, Seattle, WA, USA
Wilbrey-Clark, Anna (författare)
Wellcome Sanger Institute, Hinxton, Cambridge, UK, Cambridge
Worlock, Kaylee B. (författare)
Department of Respiratory Medicine, Division of Medicine, University College London, London, UK
Yoshida, Masahiro (författare)
Department of Respiratory Medicine, Division of Medicine, University College London, London, UK
Chen, Yuexin (författare)
Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany
Hagood, James S. (författare)
Department of Pediatrics (Pulmonology), University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Agami, Ahmed (författare)
Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany
Horvath, Peter (författare)
Biological Research Centre, Szeged, Hungary; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
Lundeberg, Joakim (författare)
KTH,Genteknologi
Marquette, Charles Hugo (författare)
Pulmonology Department, Fédération Hospitalo-Universitaire OncoAge, Centre Hospitalier Universitaire de Nice, Université Côte d’Azur, Nice, France
Pryhuber, Gloria (författare)
Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA
Samakovlis, Chistos (författare)
Lab and Department of Molecular Bioscience, Stockholm University, Stockholm, Sweden
Sun, Xin (författare)
University of California, San Diego, La Jolla, CA, USA, La Jolla
Ware, Lorraine B. (författare)
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Zhang, Kun (författare)
University of California, San Diego, La Jolla, CA, USA, La Jolla
van den Berge, Maarten (författare)
Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
Bossé, Yohan (författare)
Institut Universitaire de Cardiologie et de Pneumologie de Québec, Department of Molecular Medicine, Laval University, Quebec City, Quebec, Canada
Desai, Tushar J. (författare)
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
Eickelberg, Oliver (författare)
Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Kaminski, Naftali (författare)
Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA
Krasnow, Mark A. (författare)
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA
Lafyatis, Robert (författare)
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Nikolic, Marko Z. (författare)
Department of Respiratory Medicine, Division of Medicine, University College London, London, UK
Powell, Joseph E. (författare)
Garvan Institute of Medical Research, Sydney, New South Wales, Australia; Cellular Genomics Futures Institute, University of New South Wales, Sydney, New South Wales, Australia
Rajagopal, Jayaraj (författare)
Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Cambridge, MA, USA
Rojas, Mauricio (författare)
Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, The Ohio State University, Columbus, OH, USA
Rozenblatt-Rosen, Orit (författare)
Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Cellular and Tissue Genomics, Genentech, South San Francisco, CA, USA
Seibold, Max A. (författare)
Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA; Department of Pediatrics, National Jewish Health, Denver, CO, USA; Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO, USA
Sheppard, Dean (författare)
Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, CA, USA
Shepherd, Douglas P. (författare)
Department of Physics and Center for Biological Physics, Arizona State University, Tempe, AZ, USA
Sin, Don D. (författare)
Centre for Heart Lung Innovation, St. Paul’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
Timens, Wim (författare)
Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
Tsankov, Alexander M. (författare)
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Whitsett, Jeffrey (författare)
Division of Neonatology and Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Xu, Yan (författare)
Division of Neonatology and Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Banovich, Nicholas E. (författare)
Translational Genomics Research Institute, Phoenix, AZ, USA
Barbry, Pascal (författare)
Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d’Azur and Centre National de la Recherche Scientifique, Valbonne, France; 3IA Côte d’Azur, Nice, France
Duong, Thu Elizabeth (författare)
Department of Pediatrics, Division of Respiratory Medicine, University of California, San Diego, La Jolla, CA, USA, La Jolla
Falk, Christine S. (författare)
Institute for Transplant Immunology, Hannover Medical School, Hannover, Germany
Meyer, Kerstin B. (författare)
Wellcome Sanger Institute, Hinxton, Cambridge, UK, Cambridge
Kropski, Jonathan A. (författare)
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA
Pe’er, Dana (författare)
Howard Hughes Medical Institute, Chevy Chase, MD, USA; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Schiller, Herbert B. (författare)
Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany
Tata, Purushothama Rao (författare)
Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA
Schultze, Joachim L. (författare)
Department of Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany; PRECISE Platform for Single Cell Genomics and Epigenomics, Deutsches Zentrum für Neurodegenerative Erkrankungen and University of Bonn, Bonn, Germany
Teichmann, Sara A. (författare)
Wellcome Sanger Institute, Hinxton, Cambridge, UK, Cambridge; Department of Physics, Cavendish Laboratory, University of Cambridge, Cambridge, UK
Misharin, Alexander V. (författare)
Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Nawijn, Martijn C. (författare)
Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
Luecken, Malte D. (författare)
Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; Institute of Lung Health and Immunity (a member of the German Center for Lung Research) and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Munich, Germany
Theis, Fabian J. (författare)
Department of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Munich, Germany; TUM School of Life Sciences, Technical University of Munich, Munich, Germany; Department of Mathematics, Technical University of Munich, Garching, Germany
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 (creator_code:org_t)
Springer Nature, 2023
2023
Engelska.
Ingår i: Nature Medicine. - : Springer Nature. - 1078-8956 .- 1546-170X. ; 29:6, s. 1563-1577
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Single-cell technologies have transformed our understanding of human tissues. Yet, studies typically capture only a limited number of donors and disagree on cell type definitions. Integrating many single-cell datasets can address these limitations of individual studies and capture the variability present in the population. Here we present the integrated Human Lung Cell Atlas (HLCA), combining 49 datasets of the human respiratory system into a single atlas spanning over 2.4 million cells from 486 individuals. The HLCA presents a consensus cell type re-annotation with matching marker genes, including annotations of rare and previously undescribed cell types. Leveraging the number and diversity of individuals in the HLCA, we identify gene modules that are associated with demographic covariates such as age, sex and body mass index, as well as gene modules changing expression along the proximal-to-distal axis of the bronchial tree. Mapping new data to the HLCA enables rapid data annotation and interpretation. Using the HLCA as a reference for the study of disease, we identify shared cell states across multiple lung diseases, including SPP1 + profibrotic monocyte-derived macrophages in COVID-19, pulmonary fibrosis and lung carcinoma. Overall, the HLCA serves as an example for the development and use of large-scale, cross-dataset organ atlases within the Human Cell Atlas.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

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Av författaren/redakt...
Sikkema, Lisa
Ramírez-Suástegu ...
Strobl, Daniel C ...
Gillett, Tessa E ...
Zappia, Luke
Madissoon, Elo
visa fler...
Markov, Nikolay ...
Zaragosi, Laure ...
Ji, Yuge
Ansari, Meshal
Arguel, Marie Je ...
Apperloo, Leonie
Banchero, Martin
Bécavin, Christo ...
Berg, Marijn
Chichelnitskiy, ...
Chung, Mei i.
Collin, Antoine
Gay, Aurore C.A.
Gote-Schniering, ...
Hooshiar Kashani ...
Inecik, Kemal
Jain, Manu
Kapellos, Theodo ...
Kole, Tessa M.
Leroy, Sylvie
Mayr, Christoph ...
Oliver, Amanda J ...
von Papen, Micha ...
Peter, Lance
Taylor, Chase J.
Walzthoeni, Thom ...
Xu, Chuan
Bui, Linh T.
De Donno, Carlo
Dony, Leander
Faiz, Alen
Guo, Minzhe
Gutierrez, Austi ...
Heumos, Lukas
Huang, Ni
Ibarra, Ignacio ...
Jackson, Nathan ...
Kadur Lakshminar ...
Lotfollahi, Moha ...
Tabib, Tracy
Talavera-López, ...
Travaglini, Kyle ...
Wilbrey-Clark, A ...
Worlock, Kaylee ...
Yoshida, Masahir ...
Chen, Yuexin
Hagood, James S.
Agami, Ahmed
Horvath, Peter
Lundeberg, Joaki ...
Marquette, Charl ...
Pryhuber, Gloria
Samakovlis, Chis ...
Sun, Xin
Ware, Lorraine B ...
Zhang, Kun
van den Berge, M ...
Bossé, Yohan
Desai, Tushar J.
Eickelberg, Oliv ...
Kaminski, Naftal ...
Krasnow, Mark A.
Lafyatis, Robert
Nikolic, Marko Z ...
Powell, Joseph E ...
Rajagopal, Jayar ...
Rojas, Mauricio
Rozenblatt-Rosen ...
Seibold, Max A.
Sheppard, Dean
Shepherd, Dougla ...
Sin, Don D.
Timens, Wim
Tsankov, Alexand ...
Whitsett, Jeffre ...
Xu, Yan
Banovich, Nichol ...
Barbry, Pascal
Duong, Thu Eliza ...
Falk, Christine ...
Meyer, Kerstin B ...
Kropski, Jonatha ...
Pe’er, Dana
Schiller, Herber ...
Tata, Purushotha ...
Schultze, Joachi ...
Teichmann, Sara ...
Misharin, Alexan ...
Nawijn, Martijn ...
Luecken, Malte D ...
Theis, Fabian J.
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