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Greater male than female variability in regional brain structure across the lifespan

Wierenga, Lara M. (author)
Doucet, Gaelle E. (author)
Dima, Danai (author)
Karolinska Institutet
show more...
Agartz, Ingrid (author)
Karolinska Institutet
Aghajani, Moji (author)
Akudjedu, Theophilus N. (author)
Albajes-Eizagirre, Anton (author)
Alnaes, Dag (author)
Alpert, Kathryn, I (author)
Andreassen, Ole A. (author)
Anticevic, Alan (author)
Asherson, Philip (author)
Banaschewski, Tobias (author)
Bargallo, Nuria (author)
Baumeister, Sarah (author)
Baur-Streubel, Ramona (author)
Bertolino, Alessandro (author)
Bonvino, Aurora (author)
Boomsma, Dorret, I (author)
Borgwardt, Stefan (author)
Bourque, Josiane (author)
den Braber, Anouk (author)
Brandeis, Daniel (author)
Breier, Alan (author)
Brodaty, Henry (author)
Brouwer, Rachel M. (author)
Buitelaar, Jan K. (author)
Busatto, Geraldo F. (author)
Calhoun, Vince D. (author)
Canales-Rodriguez, Erick J. (author)
Cannon, Dara M. (author)
Caseras, Xavier (author)
Castellanos, Francisco X. (author)
Chaim-Avancini, Tiffany M. (author)
Ching, Christopher R. K. (author)
Clark, Vincent P. (author)
Conrod, Patricia J. (author)
Conzelmann, Annette (author)
Crivello, Fabrice (author)
Davey, Christopher G. (author)
Dickie, Erin W. (author)
Ehrlich, Stefan (author)
Van't Ent, Dennis (author)
Fisher, Simon E. (author)
Fouche, Jean-Paul (author)
Franke, Barbara (author)
Fuentes-Claramonte, Paola (author)
de Geus, Eco J. C. (author)
Karolinska Institutet
Di Giorgio, Annabella (author)
Glahn, David C. (author)
Gotlib, Ian H. (author)
Grabe, Hans J. (author)
Gruber, Oliver (author)
Gruner, Patricia (author)
Gur, Raquel E. (author)
Gur, Ruben C. (author)
Gurholt, Tiril P. (author)
de Haan, Lieuwe (author)
Haatveit, Beathe (author)
Harrison, Ben J. (author)
Hartman, Catharina A. (author)
Hatton, Sean N. (author)
Heslenfeld, Dirk J. (author)
van den Heuvel, Odile A. (author)
Hickie, Ian B. (author)
Hoekstra, Pieter J. (author)
Hohmann, Sarah (author)
Holmes, Avram J. (author)
Hoogman, Martine (author)
Hosten, Norbert (author)
Howells, Fleur M. (author)
Pol, Hilleke E. Hulshoff (author)
Huyser, Chaim (author)
Jahanshad, Neda (author)
James, Anthony C. (author)
Jiang, Jiyang (author)
Karolinska Institutet
Jonsson, Erik G. (author)
Joska, John A. (author)
Kalnin, Andrew J. (author)
Klein, Marieke (author)
Koenders, Laura (author)
Kolskar, Knut K. (author)
Kramer, Bernd (author)
Kuntsi, Jonna (author)
Lagopoulos, Jim (author)
Lazaro, Luisa (author)
Lebedeva, Irina S. (author)
Lee, Phil H. (author)
Lochner, Christine (author)
Machielsen, Marise W. J. (author)
Maingault, Sophie (author)
Martin, Nicholas G. (author)
Martinez-Zalacain, Ignacio (author)
Mataix-Cols, David (author)
Mazoyer, Bernard (author)
McDonald, Brenna C. (author)
McDonald, Colm (author)
McIntosh, Andrew M. (author)
McMahon, Katie L. (author)
McPhilemy, Genevieve (author)
van der Meer, Dennis (author)
Menchon, Jose M. (author)
Naaijen, Jilly (author)
Nyberg, Lars, 1966- (author)
Umeå universitet,Diagnostisk radiologi,Institutionen för integrativ medicinsk biologi (IMB)
Oosterlaan, Jaap (author)
Paloyelis, Yannis (author)
Pauli, Paul (author)
Pergola, Giulio (author)
Pomarol-Clotet, Edith (author)
Portella, Maria J. (author)
Radua, Joaquim (author)
Reif, Andreas (author)
Richard, Genevieve (author)
Roffman, Joshua L. (author)
Rosa, Pedro G. P. (author)
Sacchet, Matthew D. (author)
Sachdev, Perminder S. (author)
Salvador, Raymond (author)
Sarro, Salvador (author)
Satterthwaite, Theodore D. (author)
Saykin, Andrew J. (author)
Serpa, Mauricio H. (author)
Sim, Kang (author)
Simmons, Andrew (author)
Smoller, Jordan W. (author)
Sommer, Iris E. (author)
Soriano-Mas, Carles (author)
Stein, Dan J. (author)
Strike, Lachlan T. (author)
Szeszko, Philip R. (author)
Temmingh, Henk S. (author)
Thomopoulos, Sophia, I (author)
Tomyshev, Alexander S. (author)
Trollor, Julian N. (author)
Uhlmann, Anne (author)
Veer, Ilya M. (author)
Veltman, Dick J. (author)
Voineskos, Aristotle (author)
Volzke, Henry (author)
Walter, Henrik (author)
Wang, Lei (author)
Wang, Yang (author)
Weber, Bernd (author)
Wen, Wei (author)
West, John D. (author)
Westlye, Lars T. (author)
Whalley, Heather C. (author)
Williams, Steven C. R. (author)
Wittfeld, Katharina (author)
Wolf, Daniel H. (author)
Wright, Margaret J. (author)
Yoncheva, Yuliya N. (author)
Zanetti, Marcus, V (author)
Ziegler, Georg C. (author)
de Zubicaray, Greig, I (author)
Thompson, Paul M. (author)
Crone, Eveline A. (author)
Frangou, Sophia (author)
Tamnes, Christian K. (author)
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 (creator_code:org_t)
2020-10-12
2022
English.
In: Human Brain Mapping. - : John Wiley & Sons. - 1065-9471 .- 1097-0193. ; 43:1, s. 470-499
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed significant patterns of greater male than female between-subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)

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By the author/editor
Wierenga, Lara M ...
Doucet, Gaelle E ...
Dima, Danai
Agartz, Ingrid
Aghajani, Moji
Akudjedu, Theoph ...
show more...
Albajes-Eizagirr ...
Alnaes, Dag
Alpert, Kathryn, ...
Andreassen, Ole ...
Anticevic, Alan
Asherson, Philip
Banaschewski, To ...
Bargallo, Nuria
Baumeister, Sara ...
Baur-Streubel, R ...
Bertolino, Aless ...
Bonvino, Aurora
Boomsma, Dorret, ...
Borgwardt, Stefa ...
Bourque, Josiane
den Braber, Anou ...
Brandeis, Daniel
Breier, Alan
Brodaty, Henry
Brouwer, Rachel ...
Buitelaar, Jan K ...
Busatto, Geraldo ...
Calhoun, Vince D ...
Canales-Rodrigue ...
Cannon, Dara M.
Caseras, Xavier
Castellanos, Fra ...
Chaim-Avancini, ...
Ching, Christoph ...
Clark, Vincent P ...
Conrod, Patricia ...
Conzelmann, Anne ...
Crivello, Fabric ...
Davey, Christoph ...
Dickie, Erin W.
Ehrlich, Stefan
Van't Ent, Denni ...
Fisher, Simon E.
Fouche, Jean-Pau ...
Franke, Barbara
Fuentes-Claramon ...
de Geus, Eco J. ...
Di Giorgio, Anna ...
Glahn, David C.
Gotlib, Ian H.
Grabe, Hans J.
Gruber, Oliver
Gruner, Patricia
Gur, Raquel E.
Gur, Ruben C.
Gurholt, Tiril P ...
de Haan, Lieuwe
Haatveit, Beathe
Harrison, Ben J.
Hartman, Cathari ...
Hatton, Sean N.
Heslenfeld, Dirk ...
van den Heuvel, ...
Hickie, Ian B.
Hoekstra, Pieter ...
Hohmann, Sarah
Holmes, Avram J.
Hoogman, Martine
Hosten, Norbert
Howells, Fleur M ...
Pol, Hilleke E. ...
Huyser, Chaim
Jahanshad, Neda
James, Anthony C ...
Jiang, Jiyang
Jonsson, Erik G.
Joska, John A.
Kalnin, Andrew J ...
Klein, Marieke
Koenders, Laura
Kolskar, Knut K.
Kramer, Bernd
Kuntsi, Jonna
Lagopoulos, Jim
Lazaro, Luisa
Lebedeva, Irina ...
Lee, Phil H.
Lochner, Christi ...
Machielsen, Mari ...
Maingault, Sophi ...
Martin, Nicholas ...
Martinez-Zalacai ...
Mataix-Cols, Dav ...
Mazoyer, Bernard
McDonald, Brenna ...
McDonald, Colm
McIntosh, Andrew ...
McMahon, Katie L ...
McPhilemy, Genev ...
van der Meer, De ...
Menchon, Jose M.
Naaijen, Jilly
Nyberg, Lars, 19 ...
Oosterlaan, Jaap
Paloyelis, Yanni ...
Pauli, Paul
Pergola, Giulio
Pomarol-Clotet, ...
Portella, Maria ...
Radua, Joaquim
Reif, Andreas
Richard, Genevie ...
Roffman, Joshua ...
Rosa, Pedro G. P ...
Sacchet, Matthew ...
Sachdev, Permind ...
Salvador, Raymon ...
Sarro, Salvador
Satterthwaite, T ...
Saykin, Andrew J ...
Serpa, Mauricio ...
Sim, Kang
Simmons, Andrew
Smoller, Jordan ...
Sommer, Iris E.
Soriano-Mas, Car ...
Stein, Dan J.
Strike, Lachlan ...
Szeszko, Philip ...
Temmingh, Henk S ...
Thomopoulos, Sop ...
Tomyshev, Alexan ...
Trollor, Julian ...
Uhlmann, Anne
Veer, Ilya M.
Veltman, Dick J.
Voineskos, Arist ...
Volzke, Henry
Walter, Henrik
Wang, Lei
Wang, Yang
Weber, Bernd
Wen, Wei
West, John D.
Westlye, Lars T.
Whalley, Heather ...
Williams, Steven ...
Wittfeld, Kathar ...
Wolf, Daniel H.
Wright, Margaret ...
Yoncheva, Yuliya ...
Zanetti, Marcus, ...
Ziegler, Georg C ...
de Zubicaray, Gr ...
Thompson, Paul M ...
Crone, Eveline A ...
Frangou, Sophia
Tamnes, Christia ...
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Neurosciences
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Radiology Nuclea ...
Articles in the publication
Human Brain Mapp ...
By the university
Umeå University
Karolinska Institutet

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