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Adjuvant Capecitabi...
Adjuvant Capecitabine for Early Breast Cancer : 15-Year Overall Survival Results From a Randomized Trial
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- Joensuu, Heikki (author)
- Helsinki Univ Hosp, Dept Oncol, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
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- Kellokumpu-Lehtinen, Pirkko-Liisa (author)
- Tampere Univ Hosp, Dept Oncol, Tampere, Finland.;Tampere Univ, Tampere, Finland.
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- Huovinen, Riikka (author)
- Turku Univ Hosp, Dept Oncol, Turku, Finland.
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- Jukkola, Arja (author)
- Tampere Univ Hosp, Dept Oncol, Tampere, Finland.;Tampere Univ, Tampere, Finland.;Oulu Univ Hosp, Dept Radiotherapy & Oncol, Oulu, Finland.
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- Tanner, Minna (author)
- Tampere Univ Hosp, Dept Oncol, Tampere, Finland.;Tampere Univ, Tampere, Finland.
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- Ahlgren, Johan (author)
- Gävle Cent Hosp, Gävle, Sweden.;Acad Hosp, Reg Canc Ctr Mid Sweden, Uppsala, Sweden.
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- Auvinen, Päivi (author)
- Kuopio Univ Hosp, Ctr Canc, Kuopio, Finland.
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- Lahdenperä, Outi (author)
- Turku Univ Hosp, Dept Oncol, Turku, Finland.
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- Villman, Kenneth (author)
- Örebro Univ Hosp, Örebro, Sweden.
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- Nyandoto, Paul (author)
- Paijat Hame Cent Hosp, Lahti, Finland.
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- Nilsson, Greger (author)
- Uppsala universitet,Experimentell och klinisk onkologi,Gävle Cent Hosp, Dept Oncol, Sweden.;Visby Hosp, Sweden.
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- Poikonen-Saksela, Paula (author)
- Helsinki Univ Hosp, Dept Oncol, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
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- Kataja, Vesa (author)
- Cent Finland Cent Hosp, Jyvaskyla, Finland.
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- Bono, Petri (author)
- Helsinki Univ Hosp, Dept Oncol, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
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- Junnila, Jouni (author)
- EstiMates, Turku, Finland.
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- Lindman, Henrik (author)
- Uppsala universitet,Experimentell och klinisk onkologi
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Helsinki Univ Hosp, Dept Oncol, Helsinki, Finland;Univ Helsinki, Helsinki, Finland. Tampere Univ Hosp, Dept Oncol, Tampere, Finland.;Tampere Univ, Tampere, Finland. (creator_code:org_t)
- American Society of Clinical Oncology (ASCO), 2022
- 2022
- English.
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In: Journal of Clinical Oncology. - : American Society of Clinical Oncology (ASCO). - 0732-183X .- 1527-7755. ; 40:10, s. 1051-1058
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Abstract
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- PURPOSE: Few data are available regarding the influence of adjuvant capecitabine on long-term survival of patients with early breast cancer.METHODS: The Finland Capecitabine Trial (FinXX) is a randomized, open-label, multicenter trial that evaluates integration of capecitabine to an adjuvant chemotherapy regimen containing a taxane and an anthracycline for the treatment of early breast cancer. Between January 27, 2004, and May 29, 2007, 1,500 patients with axillary node-positive or high-risk node-negative early breast cancer were accrued. The patients were randomly allocated to either TX-CEX, consisting of three cycles of docetaxel (T) plus capecitabine (X) followed by three cycles of cyclophosphamide, epirubicin, and capecitabine (CEX, 753 patients), or to T-CEF, consisting of three cycles of docetaxel followed by three cycles of cyclophosphamide, epirubicin, and fluorouracil (CEF, 747 patients). We performed a protocol-scheduled analysis of overall survival on the basis of approximately 15-year follow-up of the patients.RESULTS: The data collection was locked on December 31, 2020. By this date, the median follow-up time of the patients alive was 15.3 years (interquartile range, 14.5-16.1 years) in the TX-CEX group and 15.4 years (interquartile range, 14.8-16.0 years) in the T-CEF group. Patients assigned to TX-CEX survived longer than those assigned to T-CEF (hazard ratio 0.81; 95% CI, 0.66 to 0.99; P = .037). The 15-year survival rate was 77.6% in the TX-CEX group and 73.3% in the T-CEF group. In exploratory subgroup analyses, patients with estrogen receptor-negative cancer and those with triple-negative cancer treated with TX-CEX tended to live longer than those treated with T-CEF.CONCLUSION: Addition of capecitabine to a chemotherapy regimen that contained docetaxel, epirubicin, and cyclophosphamide prolonged the survival of patients with early breast cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Joensuu, Heikki
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Kellokumpu-Lehti ...
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Huovinen, Riikka
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Jukkola, Arja
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Tanner, Minna
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Ahlgren, Johan
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Auvinen, Päivi
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Lahdenperä, Outi
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Villman, Kenneth
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Nyandoto, Paul
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Nilsson, Greger
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Poikonen-Saksela ...
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Kataja, Vesa
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Bono, Petri
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Junnila, Jouni
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Lindman, Henrik
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Journal of Clini ...
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Uppsala University