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Sökning: onr:"swepub:oai:DiVA.org:umu-217718" > Global effect of mo...

Global effect of modifiable risk factors on cardiovascular disease and mortality

Magnussen, Christina (författare)
Center for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; German Center for Cardiovascular Research (DZHK) Partner Site Hamburg Kiel Lübeck, Germany
Melander, O. (författare)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Leong, Darryl P. (författare)
Department of Medicine (Cardiology), McMaster University, Hamilton, Canada
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Alegre-Diaz, Jesus (författare)
Experimental Medicine Research Unit, School of Medicine, National Autonomous University of Mexico, Mexico City, Mexico
Amouyel, Philippe (författare)
Université de Lille, Inserm, Centre Hospitalier University de Lille, Institut Pasteur de Lille, UMR1167 RID-AGE Risk Factors and Molecular Determinants of Aging-Related Diseases, Epidemiology and Public Health Department, Lille, France
Aviles-Santa, Larissa (författare)
Division of Clinical and Health Services Research, National Institute on Minority Health and Health Disparities, National Institutes of Health, MD, Bethesda, United States
De Bacquer, Dirk (författare)
Department of Public Health and Primary Care, Ghent University, Ghent, Belgium
Ballantyne, Christie M. (författare)
Department of Medicine, Baylor College of Medicine, TX, Houston, United States
Bernabé-Ortiz, Antonio (författare)
Cronicas Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru
Bobak, Martin (författare)
Department of Epidemiology and Public Health, University College London, London, United Kingdom
Brenner, Hermann (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, and Network Aging Research, Heidelberg University, Heidelberg, Germany
Carrillo-Larco, Rodrigo M. (författare)
Emory Global Diabetes Research Center, Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, United States
De Lemos, James (författare)
Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, TX, Dallas, United States
Dobson, Annette (författare)
School of Public Health, University of Queensland, Brisbane, Australia
Dörr, Marcus (författare)
Department of Internal Medicine B, University Medicine Greifswald, Dzhk Partner Site Greifswald, Greifswald, Germany
Donfrancesco, Chiara (författare)
Department of Cardiovascular and Endocrine Metabolic Diseases and Aging, Istituto Superiore di Sanità, Rome, Italy
Drygas, Wojciech (författare)
Department of Epidemiology, Cardiovascular Disease Prevention and Health Promotion, National Institute of Cardiology, Lazarski University, Warsaw, Poland
Dullaart, Robin P. (författare)
Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
Engström, G. (författare)
Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
Ferrario, Marco M. (författare)
Research Center in Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy
Ferrières, Jean (författare)
Department of Cardiology, Inserm UMR1295, Toulouse Rangueil University Hospital, Toulouse, France
De Gaetano, Giovanni (författare)
Department of Epidemiology and Prevention, Irccs Neuromed, Pozzilli, Italy
Goldbourt, Uri (författare)
Department of Epidemiology, Tel Aviv University School of Public Health, Tel Aviv, Israel
Gonzalez, Clicerio (författare)
Centro de Estudios en Diabetes, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Cuernavaca, Mexico
Grassi, Guido (författare)
Clinica Medica, University of Milano Bicocca, Milan, Italy
Hodge, Allison M. (författare)
Division of Cancer Epidemiology, Cancer Council Victoria, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Australia
Hveem, Kristian (författare)
Hunt (Trøndelag Health Study) Research Center, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Trondheim, Norway
Iacoviello, Licia (författare)
Research Center in Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy; Department of Epidemiology and Prevention, Irccs Neuromed, Pozzilli, Italy
Ikram, M. Kamran (författare)
Department of Neurology, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands; Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands
Irazola, Vilma (författare)
Department of Chronic Diseases, Institute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina
Jobe, Modou (författare)
Medical Research Council Unit the Gambia, London School of Hygiene and Tropical Medicine, Banjul, Gambia
Jousilahti, Pekka (författare)
Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
Kaleebu, Pontiano (författare)
Medical Research Council Uganda Virus Research Institute, London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda
Kavousi, Maryam (författare)
Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands
Kee, Frank (författare)
The Centre for Public Health, Queens University Belfast, Belfast, United Kingdom
Khalili, Davood (författare)
Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Iran
Koenig, Wolfgang (författare)
Dzhk Partner Site Munich Heart Alliance, Technical University of Munich, Munich, Germany; German Heart Center, Technical University of Munich, Munich, Germany; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany; Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany
Kontsevaya, Anna (författare)
National Research Center for Therapy and Preventive Medicine, Ministry of Healthcare of the Russian Federation, Moscow, Russian Federation
Kuulasmaa, Kari (författare)
Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
Lackner, Karl J. (författare)
Institute of Clinical Chemistry and Laboratory Medicine, Germany; University Medical Center of the Johannes Gutenberg University Mainz, Dzhk Partner Site Rhine Main, Mainz, Germany
Leistner, David M. (författare)
University Heart and Vascular Center Frankfurt, Dzhk Partner Site Rhine Main, Frankfurt, Germany
Lind, Lars (författare)
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
Linneberg, Allan (författare)
Department of Clinical Medicine, Faculty of Health and Medical Sciences, Copenhagen, Denmark; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark
Lorenz, Thiess (författare)
Center for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; German Center for Cardiovascular Research (DZHK) Partner Site Hamburg Kiel Lübeck, Germany
Lyngbakken, Magnus Nakrem (författare)
Department of Cardiology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway; K.G. Jebsen Center for Cardiac Biomarkers, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
Malekzadeh, Reza (författare)
Liver and Pancreaticobiliary Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; Digestive Oncology Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; Digestive Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Malyutina, Sofia (författare)
Research Institute of Internal and Preventive Medicine, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russian Federation
Mathiesen, Ellisiv B. (författare)
Department of Clinical Medicine, University of Tromsø the Arctic University of Norway, Tromsø, Norway
Melander, Olle (författare)
Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
Metspalu, Andres (författare)
Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia
Miranda, J. Jaime (författare)
Cronicas Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru; Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Australia
Moitry, Marie (författare)
Department of Public Health, Strasbourg University Hospital, University of Strasbourg, Strasbourg, France
Mugisha, Joseph (författare)
Medical Research Council Uganda Virus Research Institute, London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda
Nalini, Mahdi (författare)
Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States; Digestive Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Nambi, Vijay (författare)
Michael E. DeBakey Veterans Affairs Hospital, Baylor College of Medicine, TX, Houston, United States
Ninomiya, Toshiharu (författare)
Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Oppermann, Karen (författare)
School of Medicine, University of Passo Fundo, Passo Fundo, Brazil
D'Orsi, Eleonora (författare)
Department of Public Health, Postgraduate Program in Public Health, Federal University of Santa Catarina, Florianopolis, Brazil
Pająk, Andrzej (författare)
Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland
Palmieri, Luigi (författare)
Department of Cardiovascular and Endocrine Metabolic Diseases and Aging, Istituto Superiore di Sanità, Rome, Italy
Panagiotakos, Demosthenes (författare)
School of Health Sciences and Education, Harokopio University, Athens, Greece
Perianayagam, Arokiasamy (författare)
National Council of Applied Economic Research, Delhi, India; International Institute for Population Sciences, Mumbai, India
Peters, Annette (författare)
Dzhk Partner Site Munich Heart Alliance, Technical University of Munich, Munich, Germany; Institute for Medical Information Processing, Biometry, and Epidemiology, Medical Faculty, Ludwig Maximilians Universität München, Munich, Germany; German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD) Partner Site Munich Neuherberg, Neuherberg, Germany
Poustchi, Hossein (författare)
Digestive Oncology Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; Digestive Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Prentice, Andrew M. (författare)
Medical Research Council Unit the Gambia, London School of Hygiene and Tropical Medicine, Banjul, Gambia
Prescott, Eva (författare)
Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
Risérus, Ulf (författare)
Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Sweden
Salomaa, Veikko (författare)
Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
Sans, Susana (författare)
Catalan Department of Health, Barcelona, Spain,University Medical Center Hamburg-Eppendorf
Sakata, Satoko (författare)
Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Schöttker, Ben (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, and Network Aging Research, Heidelberg University, Heidelberg, Germany
Schutte, Aletta E. (författare)
George Institute for Global Health, Sydney, Australia; School of Population Health, Kensington, Australia; Hypertension in Africa Research Team, South African Medical Research Council Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa
Sepanlou, Sadaf G. (författare)
Digestive Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Sharma, Sanjib Kumar (författare)
Department of Internal Medicine, B.P. Koirala Institute of Health Sciences, Dharan, Nepal
Shaw, Jonathan E. (författare)
Baker Heart and Diabetes Institute, Melbourne, Australia
Simons, Leon A. (författare)
University of New South Wales, Kensington, Australia
Söderberg, Stefan (författare)
Umeå universitet,Kardiologi,Avdelningen för medicin
Tamosiunas, Abdonas (författare)
Laboratory of Population Studies, Institute of Cardiology, Department of Preventive Medicine, Faculty of Public Health, Lithuanian University of Health Sciences, Kaunas, Lithuania
Thorand, Barbara (författare)
Institute for Medical Information Processing, Biometry, and Epidemiology, Medical Faculty, Ludwig Maximilians Universität München, Munich, Germany; German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD) Partner Site Munich Neuherberg, Neuherberg, Germany
Tunstall-Pedoe, Hugh (författare)
Cardiovascular Epidemiology Unit, Institute of Cardiovascular Research, University of Dundee, Dundee, United Kingdom
Twerenbold, Raphael (författare)
Center for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; German Center for Cardiovascular Research (DZHK) Partner Site Hamburg Kiel Lübeck, Germany
Vanuzzo, Diego (författare)
Monica (Monitoring Cardiovascular Diseases) Friuli Study Group, Udine, Italy
Veronesi, Giovanni (författare)
Research Center in Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy
Waibel, Julia (författare)
Center for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; German Center for Cardiovascular Research (DZHK) Partner Site Hamburg Kiel Lübeck, Germany
Wannamethee, S. Goya (författare)
Research Department of Primary Care and Population Health, University College London, London, United Kingdom
Watanabe, Masafumi (författare)
Global Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata, Japan
Wild, Philipp S. (författare)
Preventive Cardiology and Preventive Medicine, Mainz, Germany; Clinical Epidemiology and Systems Medicine, Center for Thrombosis and Hemostasis, Mainz, Germany; University Medical Center of the Johannes Gutenberg University Mainz, Dzhk Partner Site Rhine Main, Mainz, Germany; Institute for Molecular Biology, Mainz, Germany
Yao, Yao (författare)
China Center for Health Development Studies, National School of Development, Peking University, China; Key Laboratory of Epidemiology of Major Diseases, Peking University, Ministry of Education, Beijing, China
Zeng, Yi (författare)
Center for Healthy Aging and Development Studies, National School of Development, Peking University, China; Center for the Study of Aging and Human Development and Geriatrics Division, Medical School of Duke University, NC, Durham, United States
Ziegler, Andreas (författare)
Center for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa; Cardio-CARE, Davos, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland
Blankenberg, Stefan (författare)
Center for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; German Center for Cardiovascular Research (DZHK) Partner Site Hamburg Kiel Lübeck, Germany; Cardio-CARE, Davos, Switzerland
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 (creator_code:org_t)
et al 
Massachusetts Medical Society, 2023
2023
Engelska.
Ingår i: New England Journal of Medicine. - : Massachusetts Medical Society. - 0028-4793 .- 1533-4406. ; 389:14, s. 1273-1285
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.Methods: We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality.Results: Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6).Conclusions: Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825.)

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

Cardiology
Cardiology General
Coronary Disease/Myocardial Infarction
Diabetes
Endocrinology
Hypertension
Lipids
Obesity
Prevention
Public Health
Public Health General
Cardiovascular Diseases
Cohort Studies
Diabetes Mellitus
Female
Humans
Male
Middle Aged
Risk Factors
Smoking
high density lipoprotein cholesterol
adult
all cause mortality
Article
body mass
cardiovascular disease
cardiovascular mortality
cohort analysis
confidence interval
controlled study
current smoker
death
diabetes mellitus
female
follow up
groups by age and sex
human
incidence
major clinical study
male
middle aged
prevalence
proportional hazards model
risk factor
systolic blood pressure
treatment outcome
smoking

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Magnussen, Chris ...
Melander, O.
Leong, Darryl P.
Alegre-Diaz, Jes ...
Amouyel, Philipp ...
Aviles-Santa, La ...
visa fler...
De Bacquer, Dirk
Ballantyne, Chri ...
Bernabé-Ortiz, A ...
Bobak, Martin
Brenner, Hermann
Carrillo-Larco, ...
De Lemos, James
Dobson, Annette
Dörr, Marcus
Donfrancesco, Ch ...
Drygas, Wojciech
Dullaart, Robin ...
Engström, G.
Ferrario, Marco ...
Ferrières, Jean
De Gaetano, Giov ...
Goldbourt, Uri
Gonzalez, Clicer ...
Grassi, Guido
Hodge, Allison M ...
Hveem, Kristian
Iacoviello, Lici ...
Ikram, M. Kamran
Irazola, Vilma
Jobe, Modou
Jousilahti, Pekk ...
Kaleebu, Pontian ...
Kavousi, Maryam
Kee, Frank
Khalili, Davood
Koenig, Wolfgang
Kontsevaya, Anna
Kuulasmaa, Kari
Lackner, Karl J.
Leistner, David ...
Lind, Lars
Linneberg, Allan
Lorenz, Thiess
Lyngbakken, Magn ...
Malekzadeh, Reza
Malyutina, Sofia
Mathiesen, Ellis ...
Melander, Olle
Metspalu, Andres
Miranda, J. Jaim ...
Moitry, Marie
Mugisha, Joseph
Nalini, Mahdi
Nambi, Vijay
Ninomiya, Toshih ...
Oppermann, Karen
D'Orsi, Eleonora
Pająk, Andrzej
Palmieri, Luigi
Panagiotakos, De ...
Perianayagam, Ar ...
Peters, Annette
Poustchi, Hossei ...
Prentice, Andrew ...
Prescott, Eva
Risérus, Ulf
Salomaa, Veikko
Sans, Susana
Sakata, Satoko
Schöttker, Ben
Schutte, Aletta ...
Sepanlou, Sadaf ...
Sharma, Sanjib K ...
Shaw, Jonathan E ...
Simons, Leon A.
Söderberg, Stefa ...
Tamosiunas, Abdo ...
Thorand, Barbara
Tunstall-Pedoe, ...
Twerenbold, Raph ...
Vanuzzo, Diego
Veronesi, Giovan ...
Waibel, Julia
Wannamethee, S. ...
Watanabe, Masafu ...
Wild, Philipp S.
Yao, Yao
Zeng, Yi
Ziegler, Andreas
Blankenberg, Ste ...
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