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Anti-KIF20B autoant...
Anti-KIF20B autoantibodies are associated with cranial neuropathy in systemic lupus erythematosus
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- Krustev, Eugene (författare)
- Cumming School of Medicine
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- Hanly, John G. (författare)
- Dalhousie University
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- Chin, Ricky (författare)
- Cumming School of Medicine
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- Buhler, Katherine A. (författare)
- Cumming School of Medicine
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Urowitz, Murray B. (författare)
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- Gordon, Caroline (författare)
- University of Birmingham
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- Bae, Sang Cheol (författare)
- Hanyang University Hospital for Rheumatic Disease
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- Romero-Diaz, Juanita (författare)
- Salvador Zubirán National Institute of Health Sciences and Nutrition
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- Sánchez-Guerrero, Jorge (författare)
- Mount Sinai Hospital of University of Toronto
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- Bernatsky, Sasha (författare)
- McGill University Health Center
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- Wallace, Daniel J. (författare)
- University of California, Los Angeles,Cedars-Sinai Medical Center
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- Isenberg, David (författare)
- University College London
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- Rahman, Anisur (författare)
- University College London
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- Merrill, Joan T. (författare)
- Oklahoma Medical Research Foundation
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- Fortin, Paul R. (författare)
- Laval University
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Gladman, Dafna D. (författare)
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- Bruce, Ian N. (författare)
- University of Manchester
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- Petri, Michelle A. (författare)
- Johns Hopkins University School of Medicine
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- Ginzler, Ellen M. (författare)
- SUNY Downstate Health Sciences University
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- Dooley, Mary Anne (författare)
- University of North Carolina
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- Ramsey-Goldman, Rosalind (författare)
- Northwestern University Feinberg School of Medicine
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- Manzi, Susan (författare)
- Allegheny Health Network
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- Jönsen, Andreas (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Alarcón, Graciela S. (författare)
- University of Alabama at Birmingham School of Medicine
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- van Vollenhoven, Ronald F. (författare)
- University of Amsterdam
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Aranow, Cynthia (författare)
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Mackay, Meggan (författare)
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- Ruiz-Irastorza, Guillermo (författare)
- Biocruces Bizkaia Health Research Institute
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- Lim, Sam (författare)
- Emory University
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Inanc, Murat (författare)
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- Kalunian, Kenneth C. (författare)
- University of California, San Diego
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- Jacobsen, Søren (författare)
- Copenhagen University Hospital
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- Peschken, Christine A. (författare)
- University of Manitoba
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- Kamen, Diane L. (författare)
- Medical University of South Carolina
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- Askenase, Anca (författare)
- Columbia University
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- Buyon, Jill (författare)
- NYU Langone
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- Fritzler, Marvin J. (författare)
- Cumming School of Medicine
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- Clarke, Ann E. (författare)
- Cumming School of Medicine
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- Choi, May Y. (författare)
- Cumming School of Medicine
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Lupus Science and Medicine. - 2053-8790. ; 11:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background Cranial neuropathies (CN) are a rare neuropsychiatric SLE (NPSLE) manifestation. Previous studies reported that antibodies to the kinesin family member 20B (KIF20B) (anti-KIF20B) protein were associated with idiopathic ataxia and CN. We assessed anti-KIF20B as a potential biomarker for NPSLE in an international SLE inception cohort. Methods Individuals fulfilling the revised 1997 American College of Rheumatology (ACR) SLE classification criteria were enrolled from 31 centres from 1999 to 2011 and followed annually in the Systemic Lupus Erythematosus International Collaborating Clinics inception cohort. Anti-KIF20B testing was performed on baseline (within 15 months of diagnosis or first annual visit) samples using an addressable laser bead immunoassay. Logistic regression (penalised maximum likelihood and adjusting for confounding variables) examined the association between anti-KIF20B and NPSLE manifestations (1999 ACR case definitions), including CN, occurring over the first 5 years of follow-up. Results Of the 1827 enrolled cohort members, baseline serum and 5 years of follow-up data were available on 795 patients who were included in this study: 29.8% were anti-KIF20B-positive, 88.7% female, and 52.1% White. The frequency of anti-KIF20B positivity differed only for those with CN (n=10) versus without CN (n=785) (70.0% vs 29.3%; OR 5.2, 95% CI 1.4, 18.5). Compared with patients without CN, patients with CN were more likely to fulfil the ACR haematological (90.0% vs 66.1%; difference 23.9%, 95% CI 5.0%, 42.8%) and ANA (100% vs 95.7%; difference 4.3%, 95% CI 2.9%, 5.8%) criteria. In the multivariate analysis adjusting for age at baseline, female, White race and ethnicity, and ACR haematological and ANA criteria, anti-KIF20B positivity remained associated with CN (OR 5.2, 95% CI 1.4, 19.1). Conclusion Anti-KIF20B is a potential biomarker for SLE-related CN. Further studies are needed to examine how autoantibodies against KIF20B, which is variably expressed in a variety of neurological cells, contribute to disease pathogenesis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
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- art (ämneskategori)
- ref (ämneskategori)
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Krustev, Eugene
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Hanly, John G.
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Chin, Ricky
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Buhler, Katherin ...
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Urowitz, Murray ...
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Gordon, Caroline
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visa fler...
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Bae, Sang Cheol
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Romero-Diaz, Jua ...
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Sánchez-Guerrero ...
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Bernatsky, Sasha
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Wallace, Daniel ...
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Isenberg, David
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Rahman, Anisur
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Merrill, Joan T.
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Fortin, Paul R.
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Gladman, Dafna D ...
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Bruce, Ian N.
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Petri, Michelle ...
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Ginzler, Ellen M ...
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Dooley, Mary Ann ...
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Ramsey-Goldman, ...
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Manzi, Susan
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Jönsen, Andreas
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Alarcón, Graciel ...
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van Vollenhoven, ...
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Aranow, Cynthia
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Mackay, Meggan
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Ruiz-Irastorza, ...
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Lim, Sam
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Inanc, Murat
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Kalunian, Kennet ...
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Jacobsen, Søren
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Peschken, Christ ...
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Kamen, Diane L.
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Askenase, Anca
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Buyon, Jill
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Fritzler, Marvin ...
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Clarke, Ann E.
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Choi, May Y.
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