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Heart rate, intelli...
Heart rate, intelligence in adolescence, and Parkinson's disease later in life
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- Longinetti, Elisa (författare)
- Karolinska Institutet
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- Zhan, Yiqiang (författare)
- Karolinska Institutet
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- Sata, Mizuki (författare)
- Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan; Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan; Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba, Tsukuba, Japan
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- Larsson, Henrik, 1975- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- D Onofrio, Brian M. (författare)
- Karolinska Institutet
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- Iso, Hiroyasu (författare)
- Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan
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- Wirdefeldt, Karin (författare)
- Karolinska Institutet
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- Fang, Fang (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-03-06
- 2021
- Engelska.
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Ingår i: European Journal of Epidemiology. - : Springer. - 0393-2990 .- 1573-7284. ; 36:10, s. 1055-1064
- Relaterad länk:
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https://doi.org/10.1...
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https://link.springe...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- To investigate whether physical and cognitive fitness measured in late adolescence was associated with future risk of Parkinson's disease (PD). The cohort included 1,259,485 Swedish men with physical fitness, body mass index (BMI), resting heart rate (RHR), blood pressure, intelligence quotient (IQ), and stress resilience measured at the age of 17-20 in relation to conscription. Incident cases of PD were ascertained from the Swedish Patient Register. Hazard ratios were estimated from Cox models, after controlling for multiple confounders. We further performed Mendelian randomization (MR) analyses to assess the causality of the associations, using GWAS summary statistics with > 800,000 individuals. During follow-up, we identified 1,034 cases of PD (mean age at diagnosis = 53). Men with an RHR > 100 beats per minute had a higher risk of PD compared to men with an RHR of 60-100 beats per minute (HR = 1.47; 95% CI = 1.08-1.99). Men with IQ above the highest tertile had a higher risk of PD compared to men with an IQ below the lowest tertile (HR = 1.46; 95% CI = 1.19-1.79). We found no association for physical fitness, BMI, blood pressure, or stress resilience. A causal relationship was suggested by the MR analysis between IQ and PD, but not between RHR and PD. RHR and IQ in late adolescence were associated with a higher risk of PD diagnosed at relatively young age. The association of IQ with PD is likely causal, whereas the association of RHR with PD suggests that altered cardiac autonomic function might start before 20 years of age in PD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Cohort study
- Early-life exposure
- Epidemiology
- Parkinson’s disease
- Risk factor
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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