Search: WFRF:(Isomaa Bo) >
HAPT2D : high accur...
HAPT2D : high accuracy of prediction of T2D with a model combining basic and advanced data depending on availability
-
- Di Camillo, Barbara (author)
- University of Padova
-
- Hakaste, Liisa (author)
- University of Helsinki,Helsinki University Central Hospital,Folkhälsan Research Center
-
- Sambo, Francesco (author)
- University of Padova
-
show more...
-
- Gabriel, Rafael (author)
- Asociación Española Para el Desarrollo de la Epidemiología Clínica,Carlos III Health Institute
-
- Kravic, Jasmina (author)
- Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups
-
- Isomaa, Bo (author)
- Folkhälsan Research Center
-
- Tuomilehto, Jaakko (author)
- Dasman Diabetes Institute,Asociación Española Para el Desarrollo de la Epidemiología Clínica,Danube University Krems,King Abdulaziz University
-
- Alonso, Margarita (author)
- Carlos III Health Institute,Asociación Española Para el Desarrollo de la Epidemiología Clínica
-
- Longato, Enrico (author)
- University of Padova
-
- Facchinetti, Andrea (author)
- University of Padova
-
- Groop, Leif C. (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki
-
- Cobelli, Claudio (author)
- University of Padova
-
- Tuomi, Tiinamaija (author)
- Folkhälsan Research Center,University of Helsinki,Helsinki University Central Hospital
-
show less...
-
(creator_code:org_t)
- 2018
- 2018
- English 11 s.
-
In: European Journal of Endocrinology. - 1479-683X. ; 178:4, s. 331-341
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- OBJECTIVE: Type 2 diabetes arises from the interaction of physiological and lifestyle risk factors. Our objective was to develop a model for predicting the risk of T2D, which could use various amounts of background information.RESEARCH DESIGN AND METHODS: We trained a survival analysis model on 8483 people from three large Finnish and Spanish data sets, to predict the time until incident T2D. All studies included anthropometric data, fasting laboratory values, an oral glucose tolerance test (OGTT) and information on co-morbidities and lifestyle habits. The variables were grouped into three sets reflecting different degrees of information availability. Scenario 1 included background and anthropometric information; Scenario 2 added routine laboratory tests; Scenario 3 also added results from an OGTT. Predictive performance of these models was compared with FINDRISC and Framingham risk scores.RESULTS: The three models predicted T2D risk with an average integrated area under the ROC curve equal to 0.83, 0.87 and 0.90, respectively, compared with 0.80 and 0.75 obtained using the FINDRISC and Framingham risk scores. The results were validated on two independent cohorts. Glucose values and particularly 2-h glucose during OGTT (2h-PG) had highest predictive value. Smoking, marital and professional status, waist circumference, blood pressure, age and gender were also predictive.CONCLUSIONS: Our models provide an estimation of patient's risk over time and outweigh FINDRISC and Framingham traditional scores for prediction of T2D risk. Of note, the models developed in Scenarios 1 and 2, only exploited variables easily available at general patient visits.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Di Camillo, Barb ...
-
Hakaste, Liisa
-
Sambo, Francesco
-
Gabriel, Rafael
-
Kravic, Jasmina
-
Isomaa, Bo
-
show more...
-
Tuomilehto, Jaak ...
-
Alonso, Margarit ...
-
Longato, Enrico
-
Facchinetti, And ...
-
Groop, Leif C.
-
Cobelli, Claudio
-
Tuomi, Tiinamaij ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
- Articles in the publication
-
European Journal ...
- By the university
-
Lund University