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TCF7L2 Polymorphism...
TCF7L2 Polymorphism, Weight Loss and Proinsulin: Insulin Ratio in the Diabetes Prevention Program
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McCaffery, Jeanne M. (författare)
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Jablonski, Kathleen A. (författare)
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- Franks, Paul (författare)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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Dagogo-Jack, Sam (författare)
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Wing, Rena R. (författare)
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Knowler, William C. (författare)
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Delahanty, Linda (författare)
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Dabelea, Dana (författare)
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Hamman, Richard (författare)
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Shuldiner, Alan R. (författare)
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Florez, Jose C. (författare)
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(creator_code:org_t)
- 2011-07-26
- 2011
- Engelska.
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 6:7
- Relaterad länk:
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https://portal.resea... (primary) (free)
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http://dx.doi.org/10... (free)
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https://journals.plo...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Aims: TCF7L2 variants have been associated with type 2 diabetes, body mass index (BMI), and deficits in proinsulin processing and insulin secretion. Here we sought to test whether these effects were apparent in high-risk individuals and modify treatment responses. Methods: We examined the potential role of the TCF7L2 rs7903146 variant in predicting resistance to weight loss or a lack of improvement of proinsulin processing during 2.5-years of follow-up participants (N = 2,994) from the Diabetes Prevention Program (DPP), a randomized controlled trial designed to prevent or delay diabetes in high-risk adults. Results: We observed no difference in the degree of weight loss by rs7903146 genotypes. However, the T allele (conferring higher risk of diabetes) at rs7903146 was associated with higher fasting proinsulin at baseline (P, 0.001), higher baseline proinsulin: insulin ratio (p<0.0001) and increased proinsulin: insulin ratio over a median of 2.5 years of follow-up (P = 0.003). Effects were comparable across treatment arms. Conclusions: The combination of a lack of impact of the TCF7L2 genotypes on the ability to lose weight, but the presence of a consistent effect on the proinsulin: insulin ratio over the course of DPP, suggests that high-risk genotype carriers at this locus can successfully lose weight to counter diabetes risk despite persistent deficits in insulin production.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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McCaffery, Jeann ...
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Jablonski, Kathl ...
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Franks, Paul
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Dagogo-Jack, Sam
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Wing, Rena R.
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Knowler, William ...
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visa fler...
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Delahanty, Linda
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Dabelea, Dana
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Hamman, Richard
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Shuldiner, Alan ...
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Florez, Jose C.
-
visa färre...
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