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A remote digital me...
A remote digital memory composite to detect cognitive impairment in memory clinic samples in unsupervised settings using mobile devices
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- Berron, David (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,German Center for Neurodegenerative Diseases (DZNE) Magdeburg,neotiv GmbH
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- Glanz, Wenzel (author)
- Otto von Guericke University Magdeburg
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- Clark, Lindsay (author)
- University of Wisconsin-Madison
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- Basche, Kristin (author)
- University of Wisconsin-Madison
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- Grande, Xenia (author)
- Otto von Guericke University Magdeburg
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- Güsten, Jeremie (author)
- Otto von Guericke University Magdeburg,German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Billette, Ornella V. (author)
- neotiv GmbH
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- Hempen, Ina (author)
- neotiv GmbH
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- Naveed, Muhammad Hashim (author)
- neotiv GmbH
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- Diersch, Nadine (author)
- neotiv GmbH
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- Butryn, Michaela (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,Otto von Guericke University Magdeburg
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- Spottke, Annika (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Buerger, Katharina (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,University Hospital Munich
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- Perneczky, Robert (author)
- Imperial College London,Munich Cluster for Systems Neurology,German Center for Neurodegenerative Diseases (DZNE), Bonn,University Hospital Munich
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- Schneider, Anja (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,University Hospital Bonn
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- Teipel, Stefan (author)
- Universitätsmedizin Rostock,German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Wiltfang, Jens (author)
- University Medical Center Göttingen,German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Johnson, Sterling (author)
- University of Wisconsin-Madison
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- Wagner, Michael (author)
- University Hospital Bonn,German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Jessen, Frank (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Düzel, Emrah (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,Otto von Guericke University Magdeburg
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: npj Digital Medicine. - 2398-6352. ; 7:1
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Remote monitoring of cognition holds the promise to facilitate case-finding in clinical care and the individual detection of cognitive impairment in clinical and research settings. In the context of Alzheimer’s disease, this is particularly relevant for patients who seek medical advice due to memory problems. Here, we develop a remote digital memory composite (RDMC) score from an unsupervised remote cognitive assessment battery focused on episodic memory and long-term recall and assess its construct validity, retest reliability, and diagnostic accuracy when predicting MCI-grade impairment in a memory clinic sample and healthy controls. A total of 199 participants were recruited from three cohorts and included as healthy controls (n = 97), individuals with subjective cognitive decline (n = 59), or patients with mild cognitive impairment (n = 43). Participants performed cognitive assessments in a fully remote and unsupervised setting via a smartphone app. The derived RDMC score is significantly correlated with the PACC5 score across participants and demonstrates good retest reliability. Diagnostic accuracy for discriminating memory impairment from no impairment is high (cross-validated AUC = 0.83, 95% CI [0.66, 0.99]) with a sensitivity of 0.82 and a specificity of 0.72. Thus, unsupervised remote cognitive assessments implemented in the neotiv digital platform show good discrimination between cognitively impaired and unimpaired individuals, further demonstrating that it is feasible to complement the neuropsychological assessment of episodic memory with unsupervised and remote assessments on mobile devices. This contributes to recent efforts to implement remote assessment of episodic memory for case-finding and monitoring in large research studies and clinical care.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Berron, David
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Glanz, Wenzel
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Clark, Lindsay
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Basche, Kristin
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Grande, Xenia
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Güsten, Jeremie
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show more...
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Billette, Ornell ...
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Hempen, Ina
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Naveed, Muhammad ...
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Diersch, Nadine
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Butryn, Michaela
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Spottke, Annika
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Buerger, Kathari ...
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Perneczky, Rober ...
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Schneider, Anja
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Teipel, Stefan
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Wiltfang, Jens
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Johnson, Sterlin ...
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Wagner, Michael
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Jessen, Frank
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Düzel, Emrah
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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npj Digital Medi ...
- By the university
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Lund University