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Efficacy and moderators of short-term psychodynamic psychotherapy for depression : A systematic review and meta-analysis of individual participant data

Wienicke, Frederik J. (author)
Department of Clinical Psychology, Behavioural Science Institute, Radboud University, Nijmegen, Netherlands
Beutel, Manfred E. (author)
Department of Psychosomatic Medicine and Psychotherapy, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany
Zwerenz, Rüdiger (author)
Department of Psychosomatic Medicine and Psychotherapy, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany
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Brähler, Elmar (author)
Department of Psychosomatic Medicine and Psychotherapy, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany; Integrated Research and Treatment Center Adiposity Diseases, Behavioral Medicine Research Unit, Department of Psychosomatic Medicine and Psychotherapy, University of Leipzig Medical Center, Leipzig, Germany
Fonagy, Peter (author)
Department of Clinical, Educational and Health Psychology, University College London, London, UK
Luyten, Patrick (author)
Department of Clinical, Educational and Health Psychology, University College London, London, UK; Faculty of Psychology and Educational Sciences, University of Leuven, Leuven, Belgium
Constantinou, Matthew (author)
Department of Clinical, Educational and Health Psychology, University College London, London, UK
Barber, Jacques P. (author)
Gordon F. Derner School of Psychology, Adelphi University, Garden City, NY, USA
McCarthy, Kevin S. (author)
Department of Psychology, Chestnut Hill College, Philadelphia, PA, USA; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Solomonov, Nili (author)
Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medicine, New York, NY, USA
Cooper, Peter J. (author)
School of Psychology and Clinical Language Science, University of Reading, Reading, UK
De Pascalis, Leonardo (author)
Department of Psychological Science, University of Liverpool, Liverpool, UK; Department of Psychology, University of Bologna, Bologna, Italy
Johansson, Robert, 1978- (author)
Stockholms universitet,Klinisk psykologi,Department of Psychology, Stockholm University, Stockholm, Sweden
Andersson, Gerhard, Professor, 1988- (author)
Karolinska Institutet,Linköpings universitet,Psykologi,Filosofiska fakulteten,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Öron- näsa- och halskliniken,Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden,Internet, health and clinical psychology research group
Lemma, Alessandra (author)
Anna Freud National Center for Children and Families, London, UK
Town, Joel M. (author)
Center for Emotions & Health, Dalhousie University, Halifax, Nova Scotia, Canada
Abbass, Allan A. (author)
Center for Emotions & Health, Dalhousie University, Halifax, Nova Scotia, Canada
Ajilchi, Bita (author)
Department of Psychology, Faculty of Human Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
Connolly Gibbons, Mary Beth (author)
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
López-Rodríguez, Jaime (author)
National Institute of Psychiatry, Mexico City, Mexico
Villamil-Salcedo, Valerio (author)
National Institute of Psychiatry, Mexico City, Mexico
Maina, Giuseppe (author)
Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin, Italy; Psychiatric Unit, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy
Rosso, Gianluca (author)
Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin, Italy; Psychiatric Unit, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy
Twisk, Jos W. R. (author)
Department of Epidemiology and Data Science, Amsterdam University Medical Center, Amsterdam, the Netherlands
Burk, William J. (author)
Department of Developmental Psychology, Behavioural Science Institute, Radboud University, Nijmegen, the Netherlands
Spijker, Jan (author)
Department of Clinical Psychology, Behavioural Science Institute, Radboud University, Nijmegen, Netherlands; Depression Expertise Center, Pro Persona Mental Health Care, Nijmegen, the Netherlands
Cuijpers, Pim (author)
Department of Clinical, Neuro- and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
Driessen, Ellen (author)
Department of Clinical Psychology, Behavioural Science Institute, Radboud University, Nijmegen, Netherlands; Depression Expertise Center, Pro Persona Mental Health Care, Nijmegen, the Netherlands
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 (creator_code:org_t)
Elsevier, 2023
2023
English.
In: Clinical Psychology Review. - : Elsevier. - 0272-7358 .- 1873-7811. ; 101
Related links:
https://doi.org/10.1...
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https://liu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
https://urn.kb.se/re...
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  • Research review (peer-reviewed)
Abstract Subject headings
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  • Background: Short-term psychodynamic psychotherapy (STPP) is frequently used to treat depression, but it is unclear which patients might benefit specifically. Individual participant data (IPD) meta-analyses can provide more precise effect estimates than conventional meta-analyses and identify patient-level moderators. This IPD meta-analysis examined the efficacy and moderators of STPP for depression compared to control conditions.Methods: PubMed, PsycInfo, Embase, and Cochrane Library were searched September 1st, 2022, to identify randomized trials comparing STPP to control conditions for adults with depression. IPD were requested and analyzed using mixed-effects models.Results: IPD were obtained from 11 of the 13 (84.6%) studies identified (n = 771/837, 92.1%; mean age = 40.8, SD = 13.3; 79.3% female). STPP resulted in significantly lower depressive symptom levels than control conditions at post-treatment (d = −0.62, 95%CI [−0.76, −0.47], p < .001). At post-treatment, STPP was more efficacious for participants with longer rather than shorter current depressive episode durations.Conclusions: These results support the evidence base of STPP for depression and indicate episode duration as an effect modifier. This moderator finding, however, is observational and requires prospective validation in future large-scale trials.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)
SAMHÄLLSVETENSKAP  -- Psykologi -- Tillämpad psykologi (hsv//swe)
SOCIAL SCIENCES  -- Psychology -- Applied Psychology (hsv//eng)

Keyword

depression
efficacy
outcome
moderators
short-term psychodynamic psychotherapy
individual participant data meta-analysis
psykologi
Psychology

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