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Association of patients' sex with treatment outcomes after intravesical bacillus Calmette-Guerin immunotherapy for T1G3/HG bladder cancer

D'Andrea, David (author)
Med Univ Vienna, Comprehens Canc Ctr, Dept Urol, Vienna, Austria.
Soria, Francesco (author)
Univ Studies Turin, AOU Citta Salute & Sci Torino, Div Urol, Turin, Italy.
Grotenhuis, Anne J. (author)
Radboud Univ Nijmegen, Med Ctr, Dept Urol, Nijmegen, Netherlands.
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Cha, Eugene K. (author)
Cornell Univ, Weill Med Coll, Dept Urol, New York, NY USA.;Mem Sloan Kettering Canc Ctr, Dept Urol, 1275 York Ave, New York, NY 10021 USA.
Malats, Nuria (author)
Spanish Natl Canc Res Ctr CNIO, Genet & Mol Epidemiol Grp, Madrid, Spain.
Di Stasi, Savino (author)
Univ Rome, Policlin Tor Vergata, Dept Urol, Rome, Italy.
Joniau, Steven (author)
Univ Hosp Leuven, Dept Urol, Oncol & Reconstruct Urol, Leuven, Belgium.
Cai, Tommaso (author)
Santa Chiara Hosp, Dept Urol, Trento, Italy.
van Rhijn, Bas W. G. (author)
Antoni von Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Surg Oncol Urol, Amsterdam, Netherlands.
Irani, Jaques (author)
Univ Poitiers, Ctr Univ La Miletrie, Dept Urol, Poitiers, France.
Karnes, Jeffrey (author)
Mayo Clin, Dept Urol, Rochester, MN USA.
Varkarakis, John (author)
Baniel, Jack (author)
Rabin Med Ctr, Dept Urol, Tel Aviv, Israel.
Palou, Joan (author)
Univ Athens, Sismanoglio Hosp, Dept Urol, Athens, Greece.;Univ Barcelona, Dept Urol, Fundacio Puigvert, Barcelona, Spain.
Babjuk, Marek (author)
Univ Praha, Motol Hosp, Dept Urol, Prague, Czech Republic.
Spahn, Martin (author)
Univ Hosp Wuerzburg, Dept Urol, Wuertzburg, Germany.
Ardelt, Peter (author)
Univ Klin Freiburg, Dept Urol, Freiburg, Germany.
Colombo, Renzo (author)
Univ Vita Salute, Dept Urol, Osped S Raffaele, Milan, Italy.
Serretta, Vincenzo (author)
Univ Palermo, Dept Surg Oncol & Stomatol Sci, Palermo, Italy.
Dalbagni, Guido (author)
Mem Sloan Kettering Canc Ctr, Dept Urol, 1275 York Ave, New York, NY 10021 USA.
Gontero, Paolo (author)
Univ Studies Turin, AOU Citta Salute & Sci Torino, Div Urol, Turin, Italy.
Bartoletti, Riccardo (author)
Univ Pisa, Dept Translat Res & New Technol, Pisa, Italy.
Larre, Stephane (author)
CHU Reims, Dept Urol, Reims, France.
Malmström, Per-Uno (author)
Uppsala universitet,Urologkirurgi
Sylvester, Richard (author)
European Assoc Urol Nonmuscle Invas Bladder Canc, Brussels, Belgium.
Shariat, Shahrokh F. (author)
Med Univ Vienna, Comprehens Canc Ctr, Dept Urol, Vienna, Austria.;Cornell Univ, Weill Med Coll, Dept Urol, New York, NY USA.;Mem Sloan Kettering Canc Ctr, Dept Urol, 1275 York Ave, New York, NY 10021 USA.;Charles Univ Prague, Fac Med 2, Dept Urol, Prague, Czech Republic.;IM Sechenov First Moscow State Med Univ, Inst Urol & Reprod Hlth, Moscow, Russia.;Univ Jordan, Dept Urol, Amman, Jordan.;European Assoc Urol Res Fdn, Arnhem, Netherlands.
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Med Univ Vienna, Comprehens Canc Ctr, Dept Urol, Vienna, Austria Univ Studies Turin, AOU Citta Salute & Sci Torino, Div Urol, Turin, Italy. (creator_code:org_t)
2021-03-13
2021
English.
In: World journal of urology. - : Springer Nature. - 0724-4983 .- 1433-8726. ; 39:9, s. 3337-3344
Related links:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Purpose: To investigate the association of patients' sex with recurrence and disease progression in patients treated with intravesical bacillus Calmette-Guerin (BCG) for T1G3/HG urinary bladder cancer (UBC).Materials and methods: We analyzed the data of 2635 patients treated with adjuvant intravesical BCG for T1 UBC between 1984 and 2019. We accounted for missing data using multiple imputations and adjusted for covariate imbalance between males and females using inverse probability weighting (IPW). Crude and IPW-adjusted Cox regression analyses were used to estimate the hazard ratios (HR) with their 95% confidence intervals (CI) for the association of patients' sex with HG-recurrence and disease progression.Results: A total of 2170 (82%) males and 465 (18%) females were available for analysis. Overall, 1090 (50%) males and 244 (52%) females experienced recurrence, and 391 (18%) males and 104 (22%) females experienced disease progression. On IPW-adjusted Cox regression analyses, female sex was associated with disease progression (HR 1.25, 95%CI 1.01-1.56, p = 0.04) but not with recurrence (HR 1.06, 95%CI 0.92-1.22, p = 0.41). A total of 1056 patients were treated with adequate BCG. In these patients, on IPW-adjusted Cox regression analyses, patients' sex was not associated with recurrence (HR 0.99, 95%CI 0.80-1.24, p = 0.96), HG-recurrence (HR 1.00, 95%CI 0.78-1.29, p = 0.99) or disease progression (HR 1.12, 95%CI 0.78-1.60, p = 0.55).Conclusion: Our analysis generates the hypothesis of a differential response to BCG between males and females if not adequately treated. Further studies should focus on sex-based differences in innate and adaptive immune system and their association with BCG response.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Urology and Nephrology (hsv//eng)

Keyword

Bladder cancer
BCG
Response
Age
Progression
Recurrence

Publication and Content Type

ref (subject category)
art (subject category)

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