Tyck till om SwePub Sök
här!
Search: WFRF:(Kardia Sharon L. R.) >
A Peripheral Blood ...
A Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease
-
- Ma, Jiantao (author)
- NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA;Tufts Univ, Nutr Data Sci, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA
-
- Nano, Jana (author)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol, Neuherberg, Germany;German Ctr Diabet Res, Munich, Germany
-
- Ding, Jingzhong (author)
- Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA
-
show more...
-
- Zheng, Yinan (author)
- Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA
-
- Hennein, Rachel (author)
- NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA
-
- Liu, Chunyu (author)
- NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA;Boston Univ, Dept Biostat, Boston, MA 02215 USA
-
- Speliotes, Elizabeth K. (author)
- Univ Michigan, Sch Med, Ann Arbor, MI USA
-
- Huan, Tianxiao (author)
- NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA
-
- Song, Ci (author)
- Uppsala universitet,Molekylär epidemiologi,NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA
-
- Mendelson, Michael M. (author)
- NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA;Harvard Med Sch, Dept Cardiol, Boston Childrens Hosp, Boston, MA 02115 USA
-
- Joehanes, Roby (author)
- NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA
-
- Long, Michelle T. (author)
- Boston Univ, Sch Med, Dept Med, Gastroenterol Sect, Boston, MA 02118 USA
-
- Liang, Liming (author)
- Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA
-
- Smith, Jennifer A. (author)
- Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
-
- Reynolds, Lindsay M. (author)
- Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA
-
- Ghanbari, Mohsen (author)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Mashhad Univ Med Sci, Sch Med, Dept Genet, Mashhad, Razavi Khorasan, Iran
-
- Muka, Taulant (author)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands
-
- van Meurs, Joyce B. J. (author)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Erasmus MC, Dept Internal Med, Rotterdam, Netherlands
-
- Alferink, Louise J. M. (author)
- Erasmus MC, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands
-
- Franco, Oscar H. (author)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands
-
- Dehghan, Abbas (author)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Imperial Coll London, Dept Biostat & Epidemiol, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, London, England
-
- Ratliff, Scott (author)
- Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
-
- Zhao, Wei (author)
- Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
-
- Bielak, Lawrence (author)
- Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
-
- Kardia, Sharon L. R. (author)
- Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
-
- Peyser, Patricia A. (author)
- Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
-
- Ning, Hongyan (author)
- Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA
-
- VanWagner, Lisa B. (author)
- Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA;Northwestern Univ, Dept Med, Feinberg Sch Med, Div Gastroenterol & Hepatol, Chicago, IL 60611 USA
-
- Lloyd-Jones, Donald M. (author)
- Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA
-
- Carr, John Jeffrey (author)
- Vanderbilt Univ, Med Ctr, Dept Radiol & Radiol Sci, Nashville, TN 37232 USA
-
- Greenland, Philip (author)
- Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA
-
- Lichtenstein, Alice H. (author)
- Tufts Univ, USDA, Human Nutr Res Ctr Aging, Cardiovasc Nutr Lab, Boston, MA 02111 USA
-
- Hu, Frank B. (author)
- Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA
-
- Liu, Yongmei (author)
- Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA
-
- Hou, Lifang (author)
- Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA
-
- Murad, Sarwa Darwish (author)
- Erasmus MC, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands
-
- Levy, Daniel (author)
- NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA
-
show less...
-
(creator_code:org_t)
- AMER DIABETES ASSOC, 2019
- 2019
- English.
-
In: Diabetes. - : AMER DIABETES ASSOC. - 0012-1797 .- 1939-327X. ; 68:5, s. 1073-1083
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.2...
-
show less...
Abstract
Subject headings
Close
- Nonalcoholic fatty liver disease (NAFLD) is a risk factor for type 2 diabetes (T2D). We aimed to identify the peripheral blood DNA methylation signature of hepatic fat. We conducted epigenome-wide association studies of hepatic fat in 3,400 European ancestry (EA) participants and in 401 Hispanic ancestry and 724 African ancestry participants from four population-based cohort studies. Hepatic fat was measured using computed tomography or ultrasound imaging and DNA methylation was assessed at >400,000 cytosine-guanine dinucleotides (CpGs) in whole blood or CD14+ monocytes using a commercial array. We identified 22 CpGs associated with hepatic fat in EA participants at a false discovery rate <0.05 (corresponding P = 6.9 x 10(-6)) with replication at Bonferroni-corrected P < 8.6 x 10(-4). Mendelian randomization analyses supported the association of hypomethylation of cg08309687 (LINC00649) with NAFLD (P = 2.5 x 10(-4)). Hypomethylation of the same CpG was also associated with risk for new-onset T2D (P = 0.005). Our study demonstrates that a peripheral blood-derived DNA methylation signature is robustly associated with hepatic fat accumulation. The hepatic fat-associated CpGs may represent attractive biomarkers for T2D. Future studies are warranted to explore mechanisms and to examine DNA methylation signatures of NAFLD across racial/ethnic groups.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Diabetes
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Ma, Jiantao
-
Nano, Jana
-
Ding, Jingzhong
-
Zheng, Yinan
-
Hennein, Rachel
-
Liu, Chunyu
-
show more...
-
Speliotes, Eliza ...
-
Huan, Tianxiao
-
Song, Ci
-
Mendelson, Micha ...
-
Joehanes, Roby
-
Long, Michelle T ...
-
Liang, Liming
-
Smith, Jennifer ...
-
Reynolds, Lindsa ...
-
Ghanbari, Mohsen
-
Muka, Taulant
-
van Meurs, Joyce ...
-
Alferink, Louise ...
-
Franco, Oscar H.
-
Dehghan, Abbas
-
Ratliff, Scott
-
Zhao, Wei
-
Bielak, Lawrence
-
Kardia, Sharon L ...
-
Peyser, Patricia ...
-
Ning, Hongyan
-
VanWagner, Lisa ...
-
Lloyd-Jones, Don ...
-
Carr, John Jeffr ...
-
Greenland, Phili ...
-
Lichtenstein, Al ...
-
Hu, Frank B.
-
Liu, Yongmei
-
Hou, Lifang
-
Murad, Sarwa Dar ...
-
Levy, Daniel
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
- Articles in the publication
-
Diabetes
- By the university
-
Uppsala University