Characterisation of age and polarity at onset in bipolar disorder

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Search: WFRF:(Kircher T) > (2020-2022) > Characterisation of...

Characterisation of age and polarity at onset in bipolar disorder

Jonsson, Lina, 1982 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Landén, Mikael, 1966 (author): Gothenburg University,Göteborgs universitet,Karolinska Institutet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Vreeker, A. (author)

McQuillin, A. (author)

Stahl, E. A. (author)

Ruderfer, D. (author)

Grigoroiu-Serbanescu, M. (author)

Panagiotaropoulou, G. (author)

Ripke, S. (author)

Bigdeli, T. B. (author)

Stein, F. (author)

Meller, T. (author)

Meinert, S. (author)

Pelin, H. (author)

Streit, F. (author)

Papiol, S. (author)

Adams, M. J. (author)

Adolfsson, Rolf (author): Umeå universitet,Psykiatri

Adorjan, K. (author)

Agartz, I. (author): Karolinska Institutet

Aminoff, S. R. (author)

Anderson-Schmidt, H. (author)

Andreassen, O. A. (author)

Ardau, R. (author)

Aubry, J. M. (author)

Balaban, C. (author)

Bass, N. (author)

Baune, B. T. (author)

Bellivier, F. (author)

Benabarre, A. (author)

Bengesser, S. (author)

Berrettini, W. H. (author)

Boks, M. P. (author)

Bromet, E. J. (author)

Brosch, K. (author)

Budde, M. (author)

Byerley, W. (author)

Cervantes, P. (author)

Chillotti, C. (author)

Cichon, S. (author)

Clark, S. R. (author)

Comes, A. L. (author)

Corvin, A. (author)

Coryell, W. (author)

Craddock, N. (author)

Craig, D. W. (author)

Pålsson, Erik, 1975 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Cruceanu, C. (author)

Czerski, P. M. (author)

Dalkner, N. (author)

Dannlowski, U. (author)

Degenhardt, F. (author)

Del Zompo, M. (author)

DePaulo, J. R. (author)

Djurovic, S. (author)

Edenberg, H. J. (author)

Al Eissa, M. (author)

Elvsashagen, T. (author)

Etain, B. (author)

Fanous, A. H. (author)

Fellendorf, F. (author)

Fiorentino, A. (author)

Forstner, A. J. (author)

Frye, M. A. (author)

Fullerton, J. M. (author)

Gade, K. (author)

Garnham, J. (author)

Gershon, E. (author)

Gill, M. (author)

Goes, F. S. (author)

Gordon-Smith, K. (author)

Grof, P. (author)

Guzman-Parra, J. (author)

Hahn, T. (author)

Hasler, R. (author)

Heilbronner, M. (author)

Heilbronner, U. (author)

Jamain, S. (author)

Jimenez, E. (author)

Jones, I. (author)

Jones, L. (author)

Jonsson, Lina, 1982 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Kahn, R. S. (author)

Kelsoe, J. R. (author)

Kennedy, J. L. (author)

Kircher, T. (author)

Kirov, G. (author)

Kittel-Schneider, S. (author)

Klohn-Saghatolislam, F. (author)

Knowles, J. A. (author)

Kranz, T. M. (author)

Lagerberg, T. V. (author)

Landén, Mikael, 1966 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Lawson, W. B. (author)

Leboyer, M. (author)

Li, Q. Q. S. (author)

Maj, M. (author)

Malaspina, D. (author)

Manchia, M. (author)

Mayoral, F. (author)

McElroy, S. L. (author)

McInnis, M. G. (author)

McIntosh, A. M. (author)

Medeiros, H. (author)

Melle, I. (author)

Milanova, V. (author)

Mitchell, P. B. (author)

Monteleone, P. (author)

Monteleone, A. M. (author)

Nothen, M. M. (author)

Novak, T. (author)

Nurnberger, J. I. (author)

O'Brien, N. (author)

O'Connell, K. S. (author)

O'Donovan, C. (author)

O'Donovan, M. C. (author)

Opel, N. (author)

Ortiz, A. (author)

Owen, M. J. (author)

Pålsson, Erik, 1975 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Pato, C. (author)

Pato, M. T. (author)

Pawlak, J. (author)

Pfarr, J. K. (author)

Pisanu, C. (author)

Potash, J. B. (author)

Rapaport, M. H. (author)

Reich-Erkelenz, D. (author)

Reif, A. (author)

Reininghaus, E. (author)

Repple, J. (author)

Richard-Lepouriel, H. (author)

Rietschel, M. (author)

Ringwald, K. (author)

Roberts, G. (author)

Rouleau, G. (author)

Schaupp, S. (author)

Scheftner, W. A. (author)

Schmitt, S. (author)

Schofield, P. R. (author)

Schubert, K. O. (author)

Schulte, E. C. (author)

Schweizer, B. (author)

Senner, F. (author)

Severino, G. (author)

Sharp, S. (author)

Slaney, C. (author)

Smeland, O. B. (author)

Sobell, J. L. (author)

Squassina, A. (author)

Stopkova, P. (author)

Strauss, J. (author)

Tortorella, A. (author)

Turecki, G. (author)

Twarowska-Hauser, J. (author)

Veldic, M. (author)

Vieta, E. (author)

Vincent, J. B. (author)

Xu, W. (author)

Zai, C. C. (author)

Zandi, P. P. (author)

Di Florio, A. (author)

Smoller, J. W. (author)

Biernacka, J. M. (author)

McMahon, F. J. (author)

Alda, M. (author)

Muller-Myhsok, B. (author)

Koutsouleris, N. (author)

Falkai, P. (author)

Freimer, N. B. (author)

Andlauer, T. F. M. (author)

Schulze, T. G. (author)

Ophoff, R. A. (author)

show less...

(creator_code:org_t)

2021-08-25
2021
English.
In: British Journal of Psychiatry. - : Royal College of Psychiatrists. - 0007-1250 .- 1472-1465. ; 219:6, s. 659-669

Related links:: https://www.cambridg...; show more...; https://doi.org/10.1...; https://umu.diva-por... (primary) (Raw object); https://gup.ub.gu.se...; https://doi.org/10.1...; https://urn.kb.se/re...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools. Aims To examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics. Method Genome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts. Results Earlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (beta = -0.34 years, s.e. = 0.08), major depression (beta = -0.34 years, s.e. = 0.08), schizophrenia (beta = -0.39 years, s.e. = 0.08), and educational attainment (beta = -0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO. Conclusions AAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)

Keyword

Bipolar disorder
age at onset
polarity at onset
GWAS
polygenic score
genome-wide association
illness
genetics
disease
family
loci
Psychiatry
Age at onset

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

British Journal of Psychiatry (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Jonsson, Lina, 1 ...; Landén, Mikael, ...; Vreeker, A.; McQuillin, A.; Stahl, E. A.; Ruderfer, D.; show more...; Grigoroiu-Serban ...; Panagiotaropoulo ...; Ripke, S.; Bigdeli, T. B.; Stein, F.; Meller, T.; Meinert, S.; Pelin, H.; Streit, F.; Papiol, S.; Adams, M. J.; Adolfsson, Rolf; Adorjan, K.; Agartz, I.; Aminoff, S. R.; Anderson-Schmidt ...; Andreassen, O. A ...; Ardau, R.; Aubry, J. M.; Balaban, C.; Bass, N.; Baune, B. T.; Bellivier, F.; Benabarre, A.; Bengesser, S.; Berrettini, W. H ...; Boks, M. P.; Bromet, E. J.; Brosch, K.; Budde, M.; Byerley, W.; Cervantes, P.; Chillotti, C.; Cichon, S.; Clark, S. R.; Comes, A. L.; Corvin, A.; Coryell, W.; Craddock, N.; Craig, D. W.; Pålsson, Erik, 1 ...; Cruceanu, C.; Czerski, P. M.; Dalkner, N.; Dannlowski, U.; Degenhardt, F.; Del Zompo, M.; DePaulo, J. R.; Djurovic, S.; Edenberg, H. J.; Al Eissa, M.; Elvsashagen, T.; Etain, B.; Fanous, A. H.; Fellendorf, F.; Fiorentino, A.; Forstner, A. J.; Frye, M. A.; Fullerton, J. M.; Gade, K.; Garnham, J.; Gershon, E.; Gill, M.; Goes, F. S.; Gordon-Smith, K.; Grof, P.; Guzman-Parra, J.; Hahn, T.; Hasler, R.; Heilbronner, M.; Heilbronner, U.; Jamain, S.; Jimenez, E.; Jones, I.; Jones, L.; Kahn, R. S.; Kelsoe, J. R.; Kennedy, J. L.; Kircher, T.; Kirov, G.; Kittel-Schneider ...; Klohn-Saghatolis ...; Knowles, J. A.; Kranz, T. M.; Lagerberg, T. V.; Lawson, W. B.; Leboyer, M.; Li, Q. Q. S.; Maj, M.; Malaspina, D.; Manchia, M.; Mayoral, F.; McElroy, S. L.; McInnis, M. G.; McIntosh, A. M.; Medeiros, H.; Melle, I.; Milanova, V.; Mitchell, P. B.; Monteleone, P.; Monteleone, A. M ...; Nothen, M. M.; Novak, T.; Nurnberger, J. I ...; O'Brien, N.; O'Connell, K. S.; O'Donovan, C.; O'Donovan, M. C.; Opel, N.; Ortiz, A.; Owen, M. J.; Pato, C.; Pato, M. T.; Pawlak, J.; Pfarr, J. K.; Pisanu, C.; Potash, J. B.; Rapaport, M. H.; Reich-Erkelenz, ...; Reif, A.; Reininghaus, E.; Repple, J.; Richard-Lepourie ...; Rietschel, M.; Ringwald, K.; Roberts, G.; Rouleau, G.; Schaupp, S.; Scheftner, W. A.; Schmitt, S.; Schofield, P. R.; Schubert, K. O.; Schulte, E. C.; Schweizer, B.; Senner, F.; Severino, G.; Sharp, S.; Slaney, C.; Smeland, O. B.; Sobell, J. L.; Squassina, A.; Stopkova, P.; Strauss, J.; Tortorella, A.; Turecki, G.; Twarowska-Hauser ...; Veldic, M.; Vieta, E.; Vincent, J. B.; Xu, W.; Zai, C. C.; Zandi, P. P.; Di Florio, A.; Smoller, J. W.; Biernacka, J. M.; McMahon, F. J.; Alda, M.; Muller-Myhsok, B ...; Koutsouleris, N.; Falkai, P.; Freimer, N. B.; Andlauer, T. F. ...; Schulze, T. G.; Ophoff, R. A.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

Articles in the publication: British Journal ...

By the university: University of Gothenburg; Umeå University; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se