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Sökning: onr:"swepub:oai:DiVA.org:uu-423375" > Broad host range of...

Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates

Damas, Joana (författare)
Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA.
Hughes, Graham M. (författare)
Univ Coll Dublin, Sch Biol & Environm Sci, Dublin, Ireland.
Keough, Kathleen C. (författare)
Univ Calif San Francisco, Grad Program Pharmaceut Sci & Pharmacogen, Quantitat Biosci Consortium, San Francisco, CA 94117 USA.;Gladstone Inst Data Sci & Biotechnol, San Francisco, CA 94158 USA.
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Painter, Corrie A. (författare)
Broad Inst MIT & Harvard, Canc Program, Cambridge, MA 02142 USA.
Persky, Nicole S. (författare)
Broad Inst MIT & Harvard, Genet Perturbat Platform, Cambridge, MA 02142 USA.
Corbo, Marco (författare)
Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA.
Hiller, Michael (författare)
Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany.;Max Planck Inst Phys Komplexer Syst, D-01187 Dresden, Germany.;Ctr Syst Biol Dresden, D-01307 Dresden, Germany.
Koepfli, Klaus-Peter (författare)
Smithsonian Conservat Biol Inst, Ctr Species Survival, Natl Zoological Pk, Front Royal, VA 22630 USA.
Pfenning, Andreas R. (författare)
Carnegie Mellon Univ, Sch Comp Sci, Dept Computat Biol, Pittsburgh, PA 15213 USA.
Zhao, Huabin (författare)
Wuhan Univ, Tibetan Ctr Ecol & Conservat WHU TU, Hubei Key Lab Cell Homeostasis, Dept Ecol,Coll Life Sci, Wuhan 430072, Peoples R China.;Tibet Univ, Coll Sci, Lhasa 850000, Peoples R China.
Genereux, Diane P. (författare)
Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.
Swofford, Ross (författare)
Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.
Pollard, Katherine S. (författare)
Gladstone Inst Data Sci & Biotechnol, San Francisco, CA 94158 USA.;Univ Calif San Francisco, Dept Epidemiol & Biostat, Inst Computat Hlth Sci, San Francisco, CA 94158 USA.;Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94158 USA.;Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.
Ryder, Oliver A. (författare)
San Diego Zoo Inst Conservat Res, Escondido, CA 92027 USA.;Univ Calif San Diego, Dept Evolut Behav & Ecol, Div Biol, La Jolla, CA 92093 USA.
Nweeia, Martin T. (författare)
Harvard Sch Dent Med, Dept Restorat Dent & Biomat Sci, Boston, MA 02115 USA.;Case Western Reserve Univ, Sch Dent Med, Cleveland, OH 44106 USA.;Smithsonian Inst, Marine Mammal Program, Dept Vertebrate Zool, Washington, DC 20002 USA.
Lindblad-Toh, Kerstin (författare)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.
Teeling, Emma C. (författare)
Univ Coll Dublin, Sch Biol & Environm Sci, Dublin, Ireland.
Karlsson, Elinor K. (författare)
Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Univ Massachusetts, Sch Med, Bioinformat & Integrat Biol, Worcester, MA 01655 USA.;Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01655 USA.
Lewin, Harris A. (författare)
Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA.;Univ Calif Davis, Dept Evolut & Ecol, Davis, CA 95616 USA.;Univ Calif Davis, John Muir Inst Environm, Davis, CA 95616 USA.
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Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA Univ Coll Dublin, Sch Biol & Environm Sci, Dublin, Ireland. (creator_code:org_t)
2020-08-21
2020
Engelska.
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : NATL ACAD SCIENCES. - 0027-8424 .- 1091-6490. ; 117:36, s. 22311-22322
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://www.pnas.org...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19. The main receptor of SARS-CoV-2, angiotensin I converting enzyme 2 (ACE2), is now undergoing extensive scrutiny to understand the routes of transmission and sensitivity in different species. Here, we utilized a unique dataset of ACE2 sequences from 410 vertebrate species, including 252 mammals, to study the conservation of ACE2 and its potential to be used as a receptor by SARS-CoV-2. We designed a five-category binding score based on the conservation properties of 25 amino acids important for the binding between ACE2 and the SARS-CoV-2 spike protein. Only mammals fell into the medium to very high categories and only catarrhine primates into the very high category, suggesting that they are at high risk for SARS-CoV-2 infection. We employed a protein structural analysis to qualitatively assess whether amino acid changes at variable residues would be likely to disrupt ACE2/SARS-CoV-2 spike protein binding and found the number of predicted unfavorable changes significantly correlated with the binding score. Extending this analysis to human population data, we found only rare (frequency <0.001) variants in 10/25 binding sites. In addition, we found significant signals of selection and accelerated evolution in the ACE2 coding sequence across all mammals, and specific to the bat lineage. Our results, if confirmed by additional experimental data, may lead to the identification of intermediate host species for SARS-CoV-2, guide the selection of animal models of COVID-19, and assist the conservation of animals both in native habitats and in human care.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Nyckelord

SARS-CoV-2
COVID-19
ACE2
comparative genomics
species conservation

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