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Sex specific associations in genome wide association analysis of renal cell carcinoma.

Laskar, Ruhina S (author)
International Agency for Research on Cancer (IARC), Lyon, France
Muller, David C (author)
Li, Peng (author)
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Machiela, Mitchell J (author)
Ye, Yuanqing (author)
Gaborieau, Valerie (author)
Foll, Matthieu (author)
Hofmann, Jonathan N (author)
Colli, Leandro (author)
Sampson, Joshua N (author)
Wang, Zhaoming (author)
Bacq-Daian, Delphine (author)
Boland, Anne (author)
Abedi-Ardekani, Behnoush (author)
Durand, Geoffroy (author)
Le Calvez-Kelm, Florence (author)
Robinot, Nivonirina (author)
Blanche, Helene (author)
Prokhortchouk, Egor (author)
Skryabin, Konstantin G (author)
Burdett, Laurie (author)
Yeager, Meredith (author)
Radojevic-Skodric, Sanja (author)
Savic, Slavisa (author)
Karolinska Institutet
Foretova, Lenka (author)
Holcatova, Ivana (author)
Janout, Vladimir (author)
Mates, Dana (author)
Rascu, Stefan (author)
Mukeria, Anush (author)
Zaridze, David (author)
Bencko, Vladimir (author)
Cybulski, Cezary (author)
Fabianova, Eleonora (author)
Jinga, Viorel (author)
Lissowska, Jolanta (author)
Lubinski, Jan (author)
Navratilova, Marie (author)
Rudnai, Peter (author)
Świątkowska, Beata (author)
Benhamou, Simone (author)
Cancel-Tassin, Geraldine (author)
Cussenot, Olivier (author)
Trichopoulou, Antonia (author)
Riboli, Elio (author)
Overvad, Kim (author)
Panico, Salvatore (author)
Ljungberg, Börje, 1949- (author)
Umeå universitet,Urologi och andrologi
Tumkur Sitaram, Raviprakash, 1974- (author)
Umeå universitet,Urologi och andrologi
Giles, Graham G (author)
Milne, Roger L (author)
Severi, Gianluca (author)
Bruinsma, Fiona (author)
Fletcher, Tony (author)
Koppova, Kvetoslava (author)
Larsson, Susanna C (author)
Wolk, Alicja (author)
Karolinska Institutet
Banks, Rosamonde E (author)
Selby, Peter J (author)
Easton, Douglas F (author)
Pharoah, Paul (author)
Andreotti, Gabriella (author)
Beane Freeman, Laura E (author)
Koutros, Stella (author)
Albanes, Demetrius (author)
Männistö, Satu (author)
Weinstein, Stephanie (author)
Clark, Peter E (author)
Edwards, Todd L (author)
Lipworth, Loren (author)
Carol, Hallie (author)
Freedman, Matthew L (author)
Pomerantz, Mark M (author)
Cho, Eunyoung (author)
Kraft, Peter (author)
Preston, Mark A (author)
Wilson, Kathryn M (author)
Michael Gaziano, J (author)
Sesso, Howard D (author)
Black, Amanda (author)
Freedman, Neal D (author)
Huang, Wen-Yi (author)
Anema, John G (author)
Kahnoski, Richard J (author)
Lane, Brian R (author)
Noyes, Sabrina L (author)
Petillo, David (author)
Teh, Bin Tean (author)
Peters, Ulrike (author)
White, Emily (author)
Anderson, Garnet L (author)
Johnson, Lisa (author)
Luo, Juhua (author)
Chow, Wong-Ho (author)
Moore, Lee E (author)
Choueiri, Toni K (author)
Wood, Christopher (author)
Johansson, Mattias (author)
McKay, James D (author)
Brown, Kevin M (author)
Rothman, Nathaniel (author)
Lathrop, Mark G (author)
Deleuze, Jean-Francois (author)
Wu, Xifeng (author)
Brennan, Paul (author)
Chanock, Stephen J (author)
Purdue, Mark P (author)
Scelo, Ghislaine (author)
International Agency for Research on Cancer (IARC), Lyon, France
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 (creator_code:org_t)
2019-06-23
2019
English.
In: European Journal of Human Genetics. - : Springer Science and Business Media LLC. - 1018-4813 .- 1476-5438. ; 27:10, s. 1589-1598
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Renal cell carcinoma (RCC) has an undisputed genetic component and a stable 2:1 male to female sex ratio in its incidence across populations, suggesting possible sexual dimorphism in its genetic susceptibility. We conducted the first sex-specific genome-wide association analysis of RCC for men (3227 cases, 4916 controls) and women (1992 cases, 3095 controls) of European ancestry from two RCC genome-wide scans and replicated the top findings using an additional series of men (2261 cases, 5852 controls) and women (1399 cases, 1575 controls) from two independent cohorts of European origin. Our study confirmed sex-specific associations for two known RCC risk loci at 14q24.2 (DPF3) and 2p21(EPAS1). We also identified two additional suggestive male-specific loci at 6q24.3 (SAMD5, male odds ratio (ORmale) = 0.83 [95% CI = 0.78-0.89], Pmale = 1.71 × 10-8 compared with female odds ratio (ORfemale) = 0.98 [95% CI = 0.90-1.07], Pfemale = 0.68) and 12q23.3 (intergenic, ORmale = 0.75 [95% CI = 0.68-0.83], Pmale = 1.59 × 10-8 compared with ORfemale = 0.93 [95% CI = 0.82-1.06], Pfemale = 0.21) that attained genome-wide significance in the joint meta-analysis. Herein, we provide evidence of sex-specific associations in RCC genetic susceptibility and advocate the necessity of larger genetic and genomic studies to unravel the endogenous causes of sex bias in sexually dimorphic traits and diseases like RCC.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

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art (subject category)

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By the author/editor
Laskar, Ruhina S
Muller, David C
Li, Peng
Machiela, Mitche ...
Ye, Yuanqing
Gaborieau, Valer ...
show more...
Foll, Matthieu
Hofmann, Jonatha ...
Colli, Leandro
Sampson, Joshua ...
Wang, Zhaoming
Bacq-Daian, Delp ...
Boland, Anne
Abedi-Ardekani, ...
Durand, Geoffroy
Le Calvez-Kelm, ...
Robinot, Nivonir ...
Blanche, Helene
Prokhortchouk, E ...
Skryabin, Konsta ...
Burdett, Laurie
Yeager, Meredith
Radojevic-Skodri ...
Savic, Slavisa
Foretova, Lenka
Holcatova, Ivana
Janout, Vladimir
Mates, Dana
Rascu, Stefan
Mukeria, Anush
Zaridze, David
Bencko, Vladimir
Cybulski, Cezary
Fabianova, Eleon ...
Jinga, Viorel
Lissowska, Jolan ...
Lubinski, Jan
Navratilova, Mar ...
Rudnai, Peter
Świątkowska, Bea ...
Benhamou, Simone
Cancel-Tassin, G ...
Cussenot, Olivie ...
Trichopoulou, An ...
Riboli, Elio
Overvad, Kim
Panico, Salvator ...
Ljungberg, Börje ...
Tumkur Sitaram, ...
Giles, Graham G
Milne, Roger L
Severi, Gianluca
Bruinsma, Fiona
Fletcher, Tony
Koppova, Kvetosl ...
Larsson, Susanna ...
Wolk, Alicja
Banks, Rosamonde ...
Selby, Peter J
Easton, Douglas ...
Pharoah, Paul
Andreotti, Gabri ...
Beane Freeman, L ...
Koutros, Stella
Albanes, Demetri ...
Männistö, Satu
Weinstein, Steph ...
Clark, Peter E
Edwards, Todd L
Lipworth, Loren
Carol, Hallie
Freedman, Matthe ...
Pomerantz, Mark ...
Cho, Eunyoung
Kraft, Peter
Preston, Mark A
Wilson, Kathryn ...
Michael Gaziano, ...
Sesso, Howard D
Black, Amanda
Freedman, Neal D
Huang, Wen-Yi
Anema, John G
Kahnoski, Richar ...
Lane, Brian R
Noyes, Sabrina L
Petillo, David
Teh, Bin Tean
Peters, Ulrike
White, Emily
Anderson, Garnet ...
Johnson, Lisa
Luo, Juhua
Chow, Wong-Ho
Moore, Lee E
Choueiri, Toni K
Wood, Christophe ...
Johansson, Matti ...
McKay, James D
Brown, Kevin M
Rothman, Nathani ...
Lathrop, Mark G
Deleuze, Jean-Fr ...
Wu, Xifeng
Brennan, Paul
Chanock, Stephen ...
Purdue, Mark P
Scelo, Ghislaine
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cancer and Oncol ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Health Sciences
and Public Health Gl ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
Articles in the publication
European Journal ...
By the university
Uppsala University
Umeå University
Karolinska Institutet

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