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Sökning: onr:"swepub:oai:DiVA.org:umu-204076" > Risk prediction of ...

Risk prediction of atrial fibrillation and its complications in the community using hs troponin I

Börschel, Christin S. (författare)
Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
Geelhoed, Bastiaan (författare)
Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
Niiranen, Teemu (författare)
Finnish Institute for Health and Welfare, Helsinki, Finland; Deparment of Internal Medicine, University of Turku, Turku, Finland; Division of Medicine, Turku University Hospital, Turku, Finland
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Camen, Stephan (författare)
Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
Donati, Maria Benedetta (författare)
Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy
Havulinna, Aki S. (författare)
Finnish Institute for Health and Welfare, Helsinki, Finland; Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland
Gianfagna, Francesco (författare)
Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy; Mediterranea Cardiocentro, Naples, Italy
Palosaari, Tarja (författare)
Finnish Institute for Health and Welfare, Helsinki, Finland
Jousilahti, Pekka (författare)
Finnish Institute for Health and Welfare, Helsinki, Finland
Kontto, Jukka (författare)
Finnish Institute for Health and Welfare, Helsinki, Finland
Vartiainen, Erkki (författare)
Finnish Institute for Health and Welfare, Helsinki, Finland
Ojeda, Francisco M. (författare)
Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany
den Ruijter, Hester M. (författare)
Laboratory for Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
Costanzo, Simona (författare)
Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy
de Gaetano, Giovanni (författare)
Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy
Di Castelnuovo, Augusto (författare)
Mediterranea Cardiocentro, Naples, Italy
Linneberg, Allan (författare)
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Centre for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark
Vishram-Nielsen, Julie K. (författare)
Centre for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark; Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Løchen, Maja-Lisa (författare)
Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway
Koenig, Wolfgang (författare)
German Heart Centre Munich, Technical University of Munich, Munich, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance Munich, Munich, Germany; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany
Jørgensen, Torben (författare)
Centre for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Kuulasmaa, Kari (författare)
Finnish Institute for Health and Welfare, Helsinki, Finland
Blankenberg, Stefan (författare)
Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
Iacoviello, Licia (författare)
Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy; Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy
Zeller, Tanja (författare)
Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany; University Center of Cardiovascular Science, University Heart and Vascular Center Hamburg-Eppendorf, Hamburg, Germany
Söderberg, Stefan (författare)
Umeå universitet,Institutionen för folkhälsa och klinisk medicin
Salomaa, Veikko (författare)
Finnish Institute for Health and Welfare, Helsinki, Finland
Schnabel, Renate B. (författare)
Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
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 (creator_code:org_t)
2023-01-17
2023
Engelska.
Ingår i: European Journal of Clinical Investigation. - : John Wiley & Sons. - 0014-2972 .- 1365-2362. ; 53:5
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Aims: Atrial fibrillation (AF) is becoming increasingly common. Traditional cardiovascular risk factors (CVRF) do not explain all AF cases. Blood-based biomarkers reflecting cardiac injury such as high-sensitivity troponin I (hsTnI) may help close this gap.Methods: We investigated the predictive ability of hsTnI for incident AF in 45,298 participants (median age 51.4 years, 45.0% men) across European community cohorts in comparison to CVRF and established biomarkers (C-reactive protein, N-terminal pro B-type natriuretic peptide).Results: During a median follow-up of 7.7 years, 1734 (3.8%) participants developed AF. Those in the highest hsTnI quarter (≥4.2 ng/L) had a 3.91-fold (95% confidence interval (CI) 3.30, 4.63; p <.01) risk for developing AF compared to the lowest quarter (<1.4 ng/L). In multivariable-adjusted Cox proportional hazards models a statistically significant association was seen between hsTnI and AF (hazard ratio (HR) per 1 standard deviation (SD) increase in log10(hsTnI) 1.08; 95% CI 1.01, 1.16; p =.03). Inclusion of hsTnI did improve model discrimination (C-index CVRF 0.811 vs. C-index CVRF and hsTnI 0.813; p <.01). Higher hsTnI concentrations were associated with heart failure (HR per SD 1.37; 95% CI 1.12, 1.68; p <.01) and overall mortality (HR per SD 1.24; 95% CI 1.09, 1.41; p <.01).Conclusion: hsTnI as a biomarker of myocardial injury does not improve prediction of AF incidence beyond classical CVRF and NT-proBNP. However, it is associated with the AF-related disease heart failure and mortality likely reflecting underlying subclinical cardiovascular impairment.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

atrial fibrillation
biomarkers
epidemiology
high-sensitivity troponin I
N-terminal pro B-type natriuretic peptide

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

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