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Fibrinolytic gene p...
Fibrinolytic gene polymorphism and ischemic stroke
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- Jood, Katarina, 1966 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences,University of Gothenburg
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- Ladenvall, Per, 1972 (författare)
- Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute,University of Gothenburg
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- Tjärnlund-Wolf, Anna, 1974 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences,University of Gothenburg
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- Ladenvall, Claes, 1974 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences,University of Gothenburg
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- Andersson, Maria, 1975 (författare)
- Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute,University of Gothenburg
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- Nilsson, Staffan, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology
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- Blomstrand, Christian, 1942 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences,University of Gothenburg
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- Jern, Christina, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences,University of Gothenburg
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(creator_code:org_t)
- 2005
- 2005
- Engelska.
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Ingår i: Stroke. - 0039-2499 .- 1524-4628. ; 36:10, s. 2077-81
- Relaterad länk:
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https://gup.ub.gu.se...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- BACKGROUND AND PURPOSE: The tissue-type plasminogen activator (tPA) -7351C>T and the plasminogen activator inhibitor type 1 (PAI-1) -675 4G>5G polymorphisms influence transcriptional activity. Both variants have been associated with myocardial infarction, with increased risk for the T and 4G allele, respectively. In this study we investigated the possible association between these polymorphisms, the respective plasma protein levels, and ischemic stroke. METHODS: In the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS), 600 patients with acute ischemic stroke aged 18 to 69 years and 600 matched community controls were recruited. Stroke subtype was determined using Trial of Org 10172 in Acute Treatment criteria. RESULTS: There were no associations between individual genetic variants and ischemic stroke. The multivariate-adjusted odds ratio for overall ischemic stroke was 1.11 (95% CI 0.87 to 1.43) for tPA T allele carriers, and 0.84 (95% CI, 0.64 to 1.11) for subjects homozygous for the PAI-1 4G allele. When genotypes were combined, a protective effect for the tPA CC/PAI-1 4G4G genotype combination was observed (odds ratio 0.65, 95% CI 0.43 to 0.98; P<0.05). Plasma levels of tPA and PAI-1 antigen at follow-up were independently associated with overall ischemic stroke. tPA-antigen differed by stroke subtype and was highest among those with large-vessel disease and cardioembolic stroke. CONCLUSIONS: Neither the tPA -7351C>T nor the PAI-1 to 675 4G>5G polymorphism showed significant association with ischemic stroke. For the tPA CC/PAI-1 4G4G genotype combination, a protective effect was observed. Collectively, these results are consistent with a more complex role for tPA and PAI-1 in the brain as compared with the heart.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Nyckelord
- Adolescent
- Adult
- Aged
- Alleles
- Brain/metabolism
- Brain Ischemia/*genetics
- Case-Control Studies
- Cerebrovascular Accident/diagnosis/*genetics
- Female
- Fibrinolysis/*genetics
- Genotype
- Homozygote
- Humans
- Male
- Middle Aged
- Models
- Statistical
- Multivariate Analysis
- Myocardial Infarction/genetics
- Myocardium/metabolism
- Odds Ratio
- Plasminogen Activator Inhibitor 1/blood/genetics
- *Polymorphism
- Genetic
- Regression Analysis
- Research Support
- Non-U.S. Gov't
- Risk Factors
- Thrombosis/diagnosis/genetics
- Tissue Plasminogen Activator/blood/genetics
- Transcription
- Genetic
- *Polymorphism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Stroke
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Jood, Katarina, ...
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Ladenvall, Per, ...
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Tjärnlund-Wolf, ...
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Ladenvall, Claes ...
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Andersson, Maria ...
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Nilsson, Staffan ...
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Blomstrand, Chri ...
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Jern, Christina, ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Stroke
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Göteborgs universitet
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Chalmers tekniska högskola