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Increased overall and bacterial infections following myeloablative allogeneic HCT for patients with AML in CR1

Ustun, Celalettin (författare)
Rush Univ, Div Hematol Oncol Cell Therapy, Chicago, IL 60612 USA
Kim, Soyoung (författare)
Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA
Chen, Min (författare)
Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA
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Beitinjaneh, Amer M. (författare)
Univ Miami, Dept Hematol, Miami, FL USA
Brown, Valerie, I (författare)
Penn State Hershey Childrens Hosp & Coll Med, Div Pediat Oncol Hematol, Dept Pediat, Hershey, PA USA
Dahi, Parastoo B. (författare)
Mem Sloan Kettering Canc Ctr, Dept Med, Adult Bone Marrow Transplant Serv, 1275 York Ave, New York, NY 10021 USA
Daly, Andrew (författare)
Tom Baker Canc Clin, Calgary, AB, Canada
Diaz, Miguel Angel (författare)
Hosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain
Freytes, Cesar O. (författare)
Texas Transplant Inst, San Antonio, TX USA
Ganguly, Siddhartha (författare)
Univ Kansas Hlth Syst, Div Hematol Malignancy & Cellular Therapeut, Kansas City, KS USA
Hashmi, Shahrukh (författare)
Mayo Clin, Dept Internal Med, Rochester, MN USA;King Faisal Specialist Hosp & Res Ctr, Oncol Ctr, Riyadh, Saudi Arabia
Hildebrandt, Gerhard C. (författare)
Univ Kentucky, Markey Canc Ctr, Lexington, KY USA
Lazarus, Hillard M. (författare)
Case Western Reserve Univ, Dept Med, Stem Cell Transplant Program, Univ Hosp Cleveland,Div Hematol & Oncol, Cleveland, OH 44106 USA
Nishihori, Taiga (författare)
H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL USA
Olsson, Richard (författare)
Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden
Page, Kristin M. (författare)
Duke Univ, Med Ctr, Div Pediat Blood & Marrow Transplantat, Durham, NC USA
Papanicolaou, Genovefa (författare)
Mem Sloan Kettering Canc Ctr, Infect Dis Serv, New York, NY 10021 USA
Saad, Ayman (författare)
Ohio State Univ, Div Hematol, Columbus, OH 43210 USA
Seo, Sachiko (författare)
Dokkyo Med Univ, Dept Haematol & Oncol, Mibu, Tochigi, Japan
William, Basem M. (författare)
Ohio State Univ, Div Hematol, Columbus, OH 43210 USA
Wingard, John R. (författare)
Univ Florida, Dept Med, Div Hematol & Oncol, Gainesville, FL USA
Wirk, Baldeep (författare)
Seattle Canc Care Alliance, Div Bone Marrow Transplant, Seattle, WA USA
Yared, Jean A. (författare)
Univ Maryland, Blood & Marrow Transplantat Program, Div Hematol Oncol, Dept Med,Greenebaum Comprehens Canc Ctr, Baltimore, MD 21201 USA
Perales, Miguel-Angel (författare)
Mem Sloan Kettering Canc Ctr, Dept Med, Adult Bone Marrow Transplant Serv, 1275 York Ave, New York, NY 10021 USA
Auletta, Jeffery J. (författare)
Nationwide Childrens Hosp, Blood & Marrow Transplant Program, Columbus, OH USA;Nationwide Childrens Hosp, Host Def Program, Div Hematol Oncol & Blood Marrow & Transplant, Columbus, OH USA;Nationwide Childrens Hosp, Div Infect Dis, Columbus, OH USA
Komanduri, Krishna, V (författare)
Univ Miami, Dept Hematol, Miami, FL USA
Lindemans, Caroline A. (författare)
Univ Utrecht, Univ Med Ctr Utrecht, Pediat Blood & Marrow Transplantat Program, Utrecht, Netherlands;Princess Maxima Ctr Pediat Oncol, Utrecht, Netherlands
Riches, Marcie L. (författare)
Univ North Carolina Chapel Hill, Div Hematol Oncol, Chapel Hill, NC USA
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 (creator_code:org_t)
2019-08-30
2019
Engelska.
Ingår i: Blood Advances. - : American Society of Hematology. - 2473-9529 .- 2473-9537. ; 3:17, s. 2525-2536
Relaterad länk:
https://ashpublicati...
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https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Presumably, reduced-intensity/nonmyeloablative conditioning (RIC/NMA) for allogeneic hematopoietic cell transplantation (alloHCT) results in reduced infections compared with myeloablative conditioning (MAC) regimens; however, published evidence is limited. In this Center for International Blood and Marrow Transplant Research study, 1755 patients (aged >= 40 years) with acute myeloid leukemia in first complete remission were evaluated for infections occurring within 100 days after T-cell replete alloHCT. Patients receiving RIC/NMA (n = 777) compared with those receiving MAC (n = 978) were older and underwent transplantation more recently; however, the groups were similar regarding Karnofsky performance score, HCT-comorbidity index, and cytogenetic risk. One or more infections occurred in 1045 (59.5%) patients (MAC, 595 [61%]; RIC/NMA, 450 [58%]; P = .21) by day 100. The median time to initial infection after MAC conditioning occurred earlier (MAC, 15 days [range, <1-99 days]; RIC/NMA, 21 days [range, <1-100 days]; P < .001). Patients receiving MAC were more likely to experience at least 1 bacterial infection by day 100 (MAC, 46% [95% confidence interval (CI), 43-49]; RIC/NMA, 37% [95% CI, 34-41]; P = .0004), whereas at least a single viral infection was more prevalent in the RIC/NMA cohort (MAC, 34% [95% CI, 31-37]; RIC/NMA, 39% [95% CI, 36-42]; P = .046). MAC remained a risk factor for bacterial infections in multivariable analysis (relative risk, 1.44; 95% CI, 1.23-1.67; P < .0001). Moreover, the rate of any infection per patient-days at risk in the first 100 days (infection density) after alloHCT was greater for the MAC cohort (1.21; 95% CI, 1.11-1.32; P < .0001). RIC/NMA was associated with reduced infections, especially bacterial infections, in the first 100 days after alloHCT.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

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