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Impact of data extr...
Impact of data extraction errors in meta-analyses on the association between depression and peripheral inflammatory biomarkers : an umbrella review
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- Lee, San (author)
- Yonsei University College of Medicine, Republic of Korea,Yonsei Univ, South Korea; Yonsei Univ, South Korea; Yonsei Univ, South Korea
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- Lee, Keum Hwa (author)
- Yonsei University College of Medicine, Republic of Korea,Yonsei Univ, South Korea
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- Park, Kyung Mee (author)
- Yonsei University College of Medicine, Republic of Korea,Yonsei Univ, South Korea; Yonsei Univ, South Korea; Yonsei Univ, South Korea
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- Park, Sung Jong (author)
- Yonsei University College of Medicine, Republic of Korea,Yonsei Univ, South Korea; Yonsei Univ, South Korea
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- Kim, Won Jae (author)
- Yonsei University College of Medicine, Republic of Korea,Yonsei Univ, South Korea; Yonsei Univ, South Korea
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- Lee, Jinhee (author)
- Yonsei University Wonju College of Medicine, Republic of Korea,Yonsei Univ, South Korea
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- Kronbichler, Andreas (author)
- University of Cambridge, UK,Univ Cambridge, England
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- Smith, Lee (author)
- Anglia Ruskin University, UK,Anglia Ruskin Univ, England
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- Solmi, Marco (author)
- University of Ottawa, Canada; The Ottawa Hospital, Canada; King's College London, UK,Univ Ottawa, Canada; Ottawa Hosp, Canada; Univ Ottawa, Canada; Kings Coll London, England
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- Stubbs, Brendon (author)
- King's College London, UK; South London and Maudsley NHS Foundation Trust, UK,Kings Coll London, England; South London & Maudsley NHS Fdn Trust, England
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- Koyanagi, Ai (author)
- Universitat de Barcelona, Spain; ICREA, Spain,Univ Barcelona, Spain; ICREA, Spain
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- Jacob, Louis (author)
- Universitat de Barcelona, Spain; University of Versailles Saint-Quentin-en-Yvelines, France,Univ Barcelona, Spain; Univ Versailles St Quentin En Yvelines, France
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- Stickley, Andrew (author)
- Södertörns högskola,SCOHOST (Stockholm Centre for Health and Social Change),Sodertorn Univ, Sweden
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- Thompson, Trevor (author)
- University of Greenwich, UK,Univ Greenwich, England
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- Dragioti, Elena, Ph.D. (author)
- Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum
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- Oh, Hans (author)
- University of Southern California, USA,Univ Southern Calif, CA 90089 USA
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- Brunoni, Andre R (author)
- University Hospital, LMU Munich, Germany; University of Sao Paulo, Brazil; Hospital Universitario, Faculdade de Medicina da USP, Brazil,Ludwig Maximilians Univ Munchen, Germany; Univ Sao Paulo, Brazil; Univ Sao Paulo, Brazil; Hosp Univ, Brazil
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- Carvalho, Andre F (author)
- Centre for Addiction and Mental Health (CAMH), Canada; University of Toronto, Canada,Ctr Addict & Mental Hlth CAMH, Canada; Univ Toronto, Canada
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- Radua, Joaquim (author)
- Karolinska Institutet
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- An, Suk Kyoon (author)
- Yonsei University College of Medicine, Republic of Korea,Yonsei Univ, South Korea; Yonsei Univ, South Korea
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- Namkoong, Kee (author)
- Yonsei University College of Medicine, Republic of Korea,Yonsei Univ, South Korea; Yonsei Univ, South Korea
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- Lee, Eun (author)
- Yonsei University College of Medicine, Republic of Korea,Yonsei Univ, South Korea; Yonsei Univ, South Korea
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- Shin, Jae Il (author)
- Yonsei University College of Medicine, Republic of Korea,Yonsei Univ, South Korea
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- Fusar-Poli, Paolo (author)
- King's College London, UK; South London and Maudsley NHS Foundation Trust, , UK; University of Pavia, Italy,Kings Coll London, England; South London & Maudsley NHS Fdn Trust, England; Univ Pavia, Italy
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(creator_code:org_t)
- Cambridge University Press, 2023
- 2023
- English.
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In: Psychological Medicine. - : Cambridge University Press. - 0033-2917 .- 1469-8978. ; 53:5, s. 2017-2030
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: Accumulating evidence suggests that alterations in inflammatory biomarkers are important in depression. However, previous meta-analyses disagree on these associations, and errors in data extraction may account for these discrepancies.METHODS: PubMed/MEDLINE, Embase, PsycINFO, and the Cochrane Library were searched from database inception to 14 January 2020. Meta-analyses of observational studies examining the association between depression and levels of tumor necrosis factor-α (TNF-α), interleukin 1-β (IL-1β), interleukin-6 (IL-6), and C-reactive protein (CRP) were eligible. Errors were classified as follows: incorrect sample sizes, incorrectly used standard deviation, incorrect participant inclusion, calculation error, or analysis with insufficient data. We determined their impact on the results after correction thereof.RESULTS: Errors were noted in 14 of the 15 meta-analyses included. Across 521 primary studies, 118 (22.6%) showed the following errors: incorrect sample sizes (20 studies, 16.9%), incorrect use of standard deviation (35 studies, 29.7%), incorrect participant inclusion (7 studies, 5.9%), calculation errors (33 studies, 28.0%), and analysis with insufficient data (23 studies, 19.5%). After correcting these errors, 11 (29.7%) out of 37 pooled effect sizes changed by a magnitude of more than 0.1, ranging from 0.11 to 1.15. The updated meta-analyses showed that elevated levels of TNF- α, IL-6, CRP, but not IL-1β, are associated with depression.CONCLUSIONS: These findings show that data extraction errors in meta-analyses can impact findings. Efforts to reduce such errors are important in studies of the association between depression and peripheral inflammatory biomarkers, for which high heterogeneity and conflicting results have been continuously reported.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Keyword
- Data extraction error
- depression
- inflammatory biomarker
- meta-analysis
- umbrella review
Publication and Content Type
- ref (subject category)
- for (subject category)
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- By the author/editor
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Lee, San
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Lee, Keum Hwa
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Park, Kyung Mee
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Park, Sung Jong
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Kim, Won Jae
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Lee, Jinhee
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show more...
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Kronbichler, And ...
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Smith, Lee
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Solmi, Marco
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Stubbs, Brendon
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Koyanagi, Ai
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Jacob, Louis
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Stickley, Andrew
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Thompson, Trevor
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Dragioti, Elena, ...
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Oh, Hans
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Brunoni, Andre R
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Carvalho, Andre ...
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Radua, Joaquim
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An, Suk Kyoon
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Namkoong, Kee
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Lee, Eun
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Shin, Jae Il
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Fusar-Poli, Paol ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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MEDICAL AND HEAL ...
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Psychological Me ...
- By the university
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Södertörn University
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Linköping University
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Karolinska Institutet