Search: WFRF:(Lehtimaki Terho) >
SERT and NET polymo...
SERT and NET polymorphisms, temperament and antidepressant response
-
Andre, Kadri (author)
-
Kampman, Olli (author)
-
Illi, Ari (author)
-
show more...
-
Viikki, Merja (author)
-
Setala-Soikkeli, Eija (author)
-
Mononen, Nina (author)
-
Lehtimaki, Terho (author)
-
- Haraldsson, Susann (author)
- Umeå universitet,Institutionen för medicinsk biovetenskap
-
Koivisto, Pasi A. (author)
-
Leinonen, Esa (author)
-
show less...
-
(creator_code:org_t)
- 2015-03-05
- 2015
- English.
-
In: Nordic Journal of Psychiatry. - : Informa UK Limited. - 0803-9488 .- 1502-4725. ; 69:7, s. 531-538
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.3...
-
show less...
Abstract
Subject headings
Close
- Background: The genetic variations in norepinephrine transporter (NET) and serotonin transporter (SERT) genes have been associated with personality traits, several psychiatric disorders and the efficacy of antidepressant treatment. Aims: We investigated the separate effects and possible interactions between NET T-182C (rs2242446) and SERT 5-HTTLPR (rs4795541) polymorphisms on selective serotonin reuptake inhibitors (SSRI) treatment response and temperamental traits assessed by the Temperament and Character Inventory (TCI) in a clinical sample of subjects with major depressive disorder (MDD). Methods: Our sample of 97 patients with major depression completed the 107-item TCI temperament questionnaire (version IX) at the initial assessment of the study and after 6 weeks of follow-up. All subjects received selective SSRI medications. Temperament dimension scores at baseline (1) and endpoint (2) during antidepressant treatment were analyzed between NET and SERT genotypes. Results: SS-genotype of 5-HTTLPR was associated with higher baseline Persistence scores than SL- or LL-genotype. A corresponding but weaker association was found at endpoint. No differences were found between 5-HTTLPR genotypes and other temperament dimensions and 5-HTTLPR genotypes had no effect on treatment response. Conclusions: Our results suggest that the SS-genotype of 5-HTTLPR is associated with Persistence scores in patients with MDD. Higher Persistence could be viewed as a negative trait when recovering from stress and its association with short and "weaker" S-allele may be related to less efficient serotonin neurotransmission, possibly resulting in less effective coping strategies on a behavioral level.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Keyword
- Antidepressant treatment
- Depression
- NET
- SERT
- Temperament
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Andre, Kadri
-
Kampman, Olli
-
Illi, Ari
-
Viikki, Merja
-
Setala-Soikkeli, ...
-
Mononen, Nina
-
show more...
-
Lehtimaki, Terho
-
Haraldsson, Susa ...
-
Koivisto, Pasi A ...
-
Leinonen, Esa
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Medical Biotechn ...
-
and Medical Biotechn ...
- Articles in the publication
-
Nordic Journal o ...
- By the university
-
Umeå University