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Risk Factors for Ch...
Risk Factors for Chronic Obstructive Pulmonary Disease in a European Cohort of Young Adults
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de Marco, Roberto (författare)
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Accordini, Simone (författare)
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Marcon, Alessandro (författare)
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Cerveri, Isa (författare)
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Anto, Josep M. (författare)
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Gislason, Thorarinn (författare)
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Heinrich, Joachim (författare)
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- Janson, Christer (författare)
- Uppsala universitet,Lungmedicin och allergologi
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Jarvis, Deborah (författare)
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Kuenzli, Nino (författare)
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Leynaert, Benedicte (författare)
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Sunyer, Jordi (författare)
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Svanes, Cecilie (författare)
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Wjst, Matthias (författare)
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Burney, Peter (författare)
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(creator_code:org_t)
- 2011
- 2011
- Engelska.
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Ingår i: American Journal of Respiratory and Critical Care Medicine. - 1073-449X .- 1535-4970. ; 183:7, s. 891-897
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Rationale: Few studies have investigated the factors associated with the early inception of chronic obstructive pulmonary disease (COPD). Objectives: We investigated COPD risk factors in an international cohort of young adults using different spirometric definitions of the disease. Methods. We studied 4,636 subjects without asthma who had prebronchodilator FEV1/FVC measured in the European Community Respiratory Health Survey both in 1991 to 1993 (when they were 20-44 yr old) and in 1999 to 2002. COPD was defined according to the Global Initiative for Chronic Obstructive Lung Disease fixed cut-off criterion (FEV1/FVC < 0.70), and two criteria based on the Quanjer and LuftiBus reference equations (FEV1/FVC less than lower limit of normal). COPD determinants were studied using two-level Poisson regression models. Measurements and Main Results: COPD incidence ranged from 1.85 (lower limit of normal [Quanjer]) to 2.88 (Global Initiative for Chronic Obstructive Lung Disease) cases/1,000/yr. Although about half of the cases had smoked less than 20 pack-years, smoking was the main risk factor for COPD, and it accounted for 29 to 39% of the new cases during the follow-up. Airway hyperresponsiveness was the second strongest risk factor (15-17% of new cases). Other determinants were respiratory infections in childhood and a family history of asthma, whereas the role of sex, age, and of being underweight largely depended on the definition of COPD used. Conclusions: COPD may start early in life. Smoking prevention should be given the highest priority to reduce COPD occurrence. Airway hyperresponsiveness, a family history of asthma, and respiratory infections in childhood are other important determinants of COPD. We suggest the need for a definition of COPD that is not exclusively based on spirometry.
Nyckelord
- bronchial hyperreactivity
- chronic obstructive pulmonary disease
- epidemiology
- reference values
- risk factors
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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de Marco, Robert ...
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Accordini, Simon ...
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Marcon, Alessand ...
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Cerveri, Isa
-
Anto, Josep M.
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Gislason, Thorar ...
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visa fler...
-
Heinrich, Joachi ...
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Janson, Christer
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Jarvis, Deborah
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Kuenzli, Nino
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Leynaert, Benedi ...
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Sunyer, Jordi
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Svanes, Cecilie
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Wjst, Matthias
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Burney, Peter
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visa färre...
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American Journal ...
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Uppsala universitet