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Low dehydroepiandro...
Low dehydroepiandrosterone sulfate (DHEA-S) is associated with worse lung function in women
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- Pesce, Giancarlo (author)
- Univ Paris Diderot Paris 7, Dept Pathophysiol & Epidemiol Resp Dis, INSERM, UMR1152, Paris, France
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- Triebner, Kai (author)
- Univ Bergen, Dept Clin Sci, Bergen, Norway
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- Van der Plaat, Diana (author)
- Univ Paris Diderot Paris 7, Dept Pathophysiol & Epidemiol Resp Dis, INSERM, UMR1152, Paris, France
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- Courbon, Dominque (author)
- Univ Paris Diderot Paris 7, Dept Pathophysiol & Epidemiol Resp Dis, INSERM, UMR1152, Paris, France
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- Marcon, Alessandro (author)
- Univ Verona, Unit Epidemiol & Med Stat, Dept Diagnost & Publ Hlth, Verona, Italy
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- Accordini, Simone (author)
- Univ Verona, Unit Epidemiol & Med Stat, Dept Diagnost & Publ Hlth, Verona, Italy
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- Anto, Josep (author)
- ISGlobal, Barcelona, Spain
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- Dorado-Arenas, Sandra (author)
- Galdakao Hosp, Pulmonol Dept, Bizkaia, Spain
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- Gullon, Jose (author)
- Hosp Univ San Agustin, Serv Neumol, Aviles, Spain
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- Sanchez-Ramos, Jose (author)
- Univ Huelva, Dept Nursing, Huelva, Spain
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- Pin, Isabelle (author)
- Antenne Pediat CIC, Pneumol Pediat, Grenoble, France
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- Gislason, Thorarinn (author)
- Landspitali, Dept Resp Med & Sleep, Reykjavik, Iceland
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- Torén, Kjell (author)
- Univ Gothenburg, Sect Occupat & Environm Med, Gothenburg, Sweden
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- Forsberg, Bertil (author)
- Umeå universitet,Yrkes- och miljömedicin,Umeå Univ, Div Occupat & Environm Med, Umeå, Sweden
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- Lindberg, Eva (author)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Zemp, Elizabeth (author)
- Univ Basel, Dept Epidemiol & Publ Hlth, Swiss Trop & Publ Hlth Inst, Basel, Switzerland
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- Jogi, Rain (author)
- Tartu Univ Hosp, Lung Clin, Tartu, Estonia
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- Dharmage, Shyamali (author)
- Univ Melbourne, Allergy & Lung Hlth Unit, Sch Populat & Global Hlth, Melbourne, Vic, Australia
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- Probst, Nicole (author)
- Univ Basel, Dept Epidemiol & Publ Hlth, Swiss Trop & Publ Hlth Inst, Basel, Switzerland
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- Jarvis, Deborah (author)
- Imperial Coll, Populat Hlth & Occupat Dis, Natl Heart & Lung Inst, London, England
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- Garcia-Aymerich, Judith (author)
- ISGlobal, Barcelona, Spain
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- Gomez-Real, Francisco (author)
- Univ Bergen, Dept Clin Sci, Bergen, Norway
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- Leynaert, Benedicte (author)
- Univ Paris Diderot Paris 7, Dept Pathophysiol & Epidemiol Resp Dis, INSERM, UMR1152, Paris, France
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(creator_code:org_t)
- European Respiratory Society, 2018
- 2018
- English.
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In: European Respiratory Journal. - : European Respiratory Society. - 0903-1936 .- 1399-3003. ; 52
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- DHEA-S is the most abundant circulating steroid hormone in humans. Low concentrations of DHEA-S have been linked to several chronic diseases, but it is unclear if DHEA-S affects respiratory health. As part of the ALEC project [EU H2020 grant #633212], the associations of DHEA-S concentrations with lung function levels and decline were evaluated in women from the general population.Serum DHEA-S concentrations were measured in 2,250 women (28-57 years) participating in the European Community Respiratory Health Survey in 1999-2002. Associations of DHEA-S concentrations (categorized by age-adjusted quintiles) with FEV1, FVC, and the FEV1/FVC ratio were investigated using linear regression models adjusted for age, height, active and passive smoking, BMI, physical activity, education, menopausal status, and with study centre included as a random effect. Associations of DHEA-S concentrations with yearly decline in lung function (ΔFEV1, ΔFVC, ΔFEV1/FVC) were assessed in 1,340 women with spirometry data at follow-up in 2010-2014.The median (25th-75th percentile) concentration of DHEA-S was 4.2 µmol/L (2.9-6.0). The concentration of DHEA-S was significantly higher in current smokers and steadily declined with age. In fully adjusted models, women with low DHEA-S concentrations (below the 1st quintile) at baseline had worse FEV1 (-80mL, p<0.001) and FVC (-79mL, p=0.001) compared to women with higher DHEA-S levels. Low DHEA-S concentrations at baseline were associated with ΔFEV1/FVC (-0.08%/year, p=0.006), but not with ΔFEV1 or ΔFVC.The results suggest that low DHEA-S concentrations are associated with worse lung function in women, but have limited effects on lung function decline.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Publication and Content Type
- vet (subject category)
- art (subject category)
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- By the author/editor
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Pesce, Giancarlo
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Triebner, Kai
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Van der Plaat, D ...
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Courbon, Dominqu ...
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Marcon, Alessand ...
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Accordini, Simon ...
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show more...
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Anto, Josep
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Dorado-Arenas, S ...
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Gullon, Jose
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Sanchez-Ramos, J ...
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Pin, Isabelle
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Gislason, Thorar ...
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Torén, Kjell
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Forsberg, Bertil
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Lindberg, Eva
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Zemp, Elizabeth
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Jogi, Rain
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Dharmage, Shyama ...
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Probst, Nicole
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Jarvis, Deborah
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Garcia-Aymerich, ...
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Gomez-Real, Fran ...
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Leynaert, Benedi ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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European Respira ...
- By the university
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Umeå University
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Uppsala University