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Sökning: onr:"swepub:oai:DiVA.org:uu-366265" > Airway responsivene...

Airway responsiveness to methacholine and incidence of COPD : an international prospective cohort study

Marcon, Alessandro (författare)
Univ Verona, Unit Epidemiol & Med Stat, Dept Diagnost & Publ Hlth, Verona, Italy
Locatelli, Francesca (författare)
Univ Verona, Unit Epidemiol & Med Stat, Dept Diagnost & Publ Hlth, Verona, Italy
Keidel, Dirk (författare)
Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland; Univ Basel, Basel, Switzerland
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Beckmeyer-Borowko, Anna B. (författare)
Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland; Univ Basel, Basel, Switzerland
Cerveri, Isa (författare)
Univ Pavia, IRCCS, San Matteo Hosp Fdn, Pavia, Italy
Dharmage, Shyamali C. (författare)
Univ Melbourne, Allergy & Lung Hlth Unit, Sch Populat & Global Hlth, Parkville, Vic, Australia
Fuertes, Elaine (författare)
Ctr Res Environm Epidemiol CREAL, Inst Global Hlth ISGlobal, Barcelona, Spain; UPF, Barcelona, Spain; CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain
Garcia-Aymerich, Judith (författare)
Ctr Res Environm Epidemiol CREAL, Inst Global Hlth ISGlobal, Barcelona, Spain; UPF, Barcelona, Spain; CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain
Heinrich, Joachim (författare)
Ludwig Maximilians Univ Munchen, Inst & Outpatient Clin Occupat Social & Environm, Univ Hosp, Munich, Germany; German Ctr Lung Res, Comprehens Pneumol Ctr Munich, Munich, Germany
Imboden, Medea (författare)
Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland; Univ Basel, Basel, Switzerland
Janson, Christer (författare)
Uppsala universitet,Lung- allergi- och sömnforskning
Johannessen, Ane (författare)
Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway
Leynaert, Benedicte (författare)
Univ Paris Diderot Paris 7, INSERM, UMR 1152, Pathophysiol & Epidemiol Resp Dis, Paris, France
Erquicia, Silvia Pascual (författare)
Galdakao Hosp, Resp Dept, OSI Barrualde Galdakao, Biscay, Spain
Pesce, Giancarlo (författare)
Univ Verona, Unit Epidemiol & Med Stat, Dept Diagnost & Publ Hlth, Verona, Italy
Schaffner, Emmanuel (författare)
Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland; Univ Basel, Basel, Switzerland
Svanes, Cecilie (författare)
Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway; Haukeland Hosp, Dept Occupat Med, Bergen, Norway
Urrutia, Isabel (författare)
Galdakao Hosp, Resp Dept, OSI Barrualde Galdakao, Biscay, Spain
Jarvis, Deborah (författare)
Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England; Imperial Coll London, Populat Hlth & Occupat Dis, Natl Heart & Lung Inst, London, England
Probst-Hensch, Nicole M. (författare)
Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland; Univ Basel, Basel, Switzerland
Accordini, Simone (författare)
Univ Verona, Unit Epidemiol & Med Stat, Dept Diagnost & Publ Hlth, Verona, Italy
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 (creator_code:org_t)
2018-05-02
2018
Engelska.
Ingår i: Thorax. - : BMJ PUBLISHING GROUP. - 0040-6376 .- 1468-3296. ; 73:9, s. 825-832
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://thorax.bmj.c...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: It has been debated, but not yet established, whether increased airway responsiveness can predict COPD. Recognising this link may help in identifying subjects at risk.Objective: We studied prospectively whether airway responsiveness is associated with the risk of developing COPD.Methods: We pooled data from two multicentre cohort studies that collected data from three time points using similar methods (European Community Respiratory Health Survey and Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults). We classified subjects (median age 37 years, 1st–3rd quartiles: 29–44) by their level of airway responsiveness using quintiles of methacholine dose–response slope at the first examination (1991–1994). Then, we excluded subjects with airflow obstruction at the second examination (1999–2003) and analysed incidence of COPD (postbronchodilator FEV1/FVC below the lower limit of normal) at the third examination (2010–2014) as a function of responsiveness, adjusting for sex, age, education, body mass index, history of asthma, smoking, occupational exposures and indicators of airway calibre.Results: We observed 108 new cases of COPD among 4205 subjects during a median time of 9 years. Compared with the least responsive group (incidence rate 0.6 per 1000/year), adjusted incidence rate ratios for COPD ranged from 1.79 (95% CI 0.52 to 6.13) to 8.91 (95% CI 3.67 to 21.66) for increasing airway responsiveness. Similar dose–response associations were observed between smokers and non-smokers, and stronger associations were found among subjects without a history of asthma or asthma-like symptoms.Conclusions: Our study suggests that increased airway responsiveness is an independent risk factor for COPD. Further research should clarify whether early treatment in patients with high responsiveness can slow down disease progression.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

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