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Long-term outcomes ...
Long-term outcomes in mild/moderate chronic obstructive pulmonary disease in the European community respiratory health survey
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de Marco, Roberto (författare)
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Accordini, Simone (författare)
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Antò, Josep M (författare)
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Gislason, Thorarinn (författare)
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Heinrich, Joachim (författare)
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- Janson, Christer (författare)
- Uppsala universitet,Lungmedicin och allergologi
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Jarvis, Deborah (författare)
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Künzli, Nino (författare)
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Leynaert, Bénédicte (författare)
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Marcon, Alessandro (författare)
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Sunyer, Jordi (författare)
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Svanes, Cecilie (författare)
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Wjst, Matthias (författare)
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Burney, Peter (författare)
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(creator_code:org_t)
- 2009
- 2009
- Engelska.
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Ingår i: American Journal of Respiratory and Critical Care Medicine. - 1073-449X .- 1535-4970. ; 180:10, s. 956-963
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- RATIONALE: Little is known about the long-term outcomes of individuals with mild/moderate chronic obstructive pulmonary disease (COPD) according to spirometric criteria. OBJECTIVES: To test whether nonsmokers and asymptomatic subjects with a spirometric diagnosis of COPD have a steeper decrease in lung function and higher hospitalization rates than subjects without airway obstruction. METHODS: A total of 5,205 subjects without asthma (20-44 years of age) from the general population, with FEV(1) >or= 50% predicted at baseline, were followed for 9 years in the frame of an international cohort study. Percent decrease in FEV(1) (DeltaFEV(1)%) and the annual hospitalization rate for respiratory causes during the follow-up were assessed for each subject. MEASUREMENTS AND MAIN RESULTS: At baseline, 324 (6.2%) subjects had the prebronchodilator FEV(1)/FVC ratio less than the lower limit of normal (LLN-COPD), and 105 (2.0%) subjects had the same ratio less than 0.70 (modified GOLD-COPD). At follow-up, smokers with LLN-COPD (n = 205) had a greater mean DeltaFEV(1)% (1.7%; 95% confidence interval [CI], 0.8-2.7) and a higher hospitalization rate (rate ratio [RR], 2.52; 95% CI, 1.65-3.86) than normal subjects. Similarly, symptomatic subjects with LLN-COPD (n = 104) had DeltaFEV(1)% (2.0%; 95% CI, 0.8-3.3) and the hospitalization rate (RR, 4.18; 95% CI, 2.43-7.21) higher than the reference group. By contrast, nonsmokers and asymptomatic subjects with LLN-COPD had outcomes that were similar or even better than normal subjects. Among subjects with LLN-COPD, the association of symptoms with DeltaFEV(1)% varied according to smoking habits (P = 0.007); it was particularly strong in symptomatic smokers and disappeared in symptomatic nonsmokers. Similar results were found with the modified GOLD classification. CONCLUSIONS: In relatively young populations, COPD is associated with poor long-term outcomes in smokers and in symptomatic subjects only.
Nyckelord
- COPD
- cohort studies
- spirometry
- hospitalization
- smoking
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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de Marco, Robert ...
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Accordini, Simon ...
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Antò, Josep M
-
Gislason, Thorar ...
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Heinrich, Joachi ...
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Janson, Christer
-
visa fler...
-
Jarvis, Deborah
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Künzli, Nino
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Leynaert, Bénédi ...
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Marcon, Alessand ...
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Sunyer, Jordi
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Svanes, Cecilie
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Wjst, Matthias
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Burney, Peter
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visa färre...
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American Journal ...
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Uppsala universitet