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Breed Distribution ...
Breed Distribution of SOD1 Alleles Previously Associated with Canine Degenerative Myelopathy
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Zeng, R. (författare)
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Coates, J. R. (författare)
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Johnson, G. C. (författare)
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visa fler...
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Hansen, L. (författare)
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Awano, T. (författare)
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Kolicheski, A. (författare)
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Ivansson, Emma (författare)
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Perloski, M. (författare)
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Lindblad-Toh, Kerstin (författare)
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O'Brien, D. P. (författare)
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Guo, J. (författare)
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Katz, M. L. (författare)
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Johnson, G. S. (författare)
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visa färre...
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(utgivare)
- 2014
- 2014
- Engelska.
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Ingår i: Journal of Veterinary Internal Medicine. - 0891-6640. ; 28:2, 515-521
Abstract
Ämnesord
Stäng
- Background Previous reports associated 2 mutant SOD1 alleles (SOD1:c.118A and SOD1:c.52T) with degenerative myelopathy in 6 canine breeds. The distribution of these alleles in other breeds has not been reported. Objective To describe the distribution of SOD1:c.118A and SOD1:c.52T in 222 breeds. Animals DNA from 33,747 dogs was genotyped at SOD1:c.118, SOD1:c.52, or both. Spinal cord sections from 249 of these dogs were examined. Methods Retrospective analysis of 35,359 previously determined genotypes at SOD1:c.118G>A or SOD1:c.52A>T and prospective survey to update the clinical status of a subset of dogs from which samples were obtained with a relatively low ascertainment bias. Results The SOD1:c.118A allele was found in cross-bred dogs and in 124 different canine breeds whereas the SOD1:c.52T allele was only found in Bernese Mountain Dogs. Most of the dogs with histopathologically confirmed degenerative myelopathy were SOD1:c.118A homozygotes, but 8 dogs with histopathologically confirmed degenerative myelopathy were SOD1:c.118A/G heterozygotes and had no other sequence variants in their SOD1 amino acid coding regions. The updated clinical conditions of dogs from which samples were obtained with a relatively low ascertainment bias suggest that SOD1:c.118A homozygotes are at a much higher risk of developing degenerative myelopathy than are SOD1:c.118A/G heterozygotes. Conclusions and Clinical Importance We conclude that the SOD1:c.118A allele is widespread and common among privately owned dogs whereas the SOD1:c.52T allele is rare and appears to be limited to Bernese Mountain Dogs. We also conclude that breeding to avoid the production of SOD1:c.118A homozygotes is a rational strategy.
Ämnesord
- Medical and Health Sciences (hsv)
- Medicin och hälsovetenskap (hsv)
Nyckelord
- Amyotrophic lateral sclerosis
- Cytoplasmic aggregates
- Spinal cord
- DNA test
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Till lärosätets databas
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Zeng, R.
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Coates, J. R.
-
Johnson, G. C.
-
Hansen, L.
-
Awano, T.
-
Kolicheski, A.
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visa fler...
-
Ivansson, Emma
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Perloski, M.
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Lindblad-Toh, Ke ...
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O'Brien, D. P.
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Guo, J.
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Katz, M. L.
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Johnson, G. S.
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visa färre...
- Av lärosätet
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