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Integration of metabolomics and expression of glycerol-3-phosphate acyltransferase (GPAM) in breast cancer-link to patient survival, hormone receptor status, and metabolic profiling

Brockmöller, Scarlet F. (författare)
Institute of Pathology, Charité- Universitätsmedizin Berlin, Berlin, Germany
Bucher, Elmar (författare)
Medical Biotechnology, VTT Technical Research Centre of Finland, University of Turku, Turku, Finland
Müller, Berit M. (författare)
Institute of Pathology, Charité- Universitätsmedizin Berlin, Berlin, Germany
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Budczies, Jan (författare)
Institute of Pathology, Charité- Universitätsmedizin Berlin, Berlin, Germany
Hilvo, Mika (författare)
VTT Technical Research Centre of Finland, Espoo, Finland
Griffin, Julian L. (författare)
Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
Oresic, Matej, 1967- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,VTT Technical Research Centre of Finland, Espoo, Finland
Kallioniemi, Olli (författare)
VTT Technical Research Centre of Finland, Espoo, Finland
Iljin, Kristiina (författare)
VTT Technical Research Centre of Finland, Espoo, Finland
Loibl, Sibylle (författare)
German Breast Group, GBG-Forschungs GmbH, Neu-Isenburg, Germany
Darb-Esfahani, Silvia (författare)
Institute of Pathology, Charité- Universitätsmedizin Berlin, Berlin, Germany
Sinn, Bruno V. (författare)
Institute of Pathology, Charité- Universitätsmedizin Berlin, Berlin, Germany
Klauschen, Frederick (författare)
Institute of Pathology, Charité- Universitätsmedizin Berlin, Berlin, Germany
Prinzler, Judith (författare)
Institute of Pathology, Charité- Universitätsmedizin Berlin, Berlin, Germany
Bangemann, Nikola (författare)
Breast Cancer Center, Charité University Hospital, Berlin, Germany
Ismaeel, Fakher (författare)
Department of Gynaecology and Obstetrics, DRK Kliniken Köpenick, Berlin, Germany; Department of Gynaecology and Obstetrics, Charité University Hospital, Berlin, Germany
Fiehn, Oliver (författare)
Genome Center, University of California-Davis, Davis CA, United States
Dietel, Manfred (författare)
Institute of Pathology, Charité- Universitätsmedizin Berlin, Berlin, Germany
Denkert, Carsten (författare)
Institute of Pathology, Charité- Universitätsmedizin Berlin, Berlin, Germany
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 (creator_code:org_t)
2011-12-15
2012
Engelska.
Ingår i: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 11:2, s. 850-60
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Changes in lipid metabolism are an important but not well-characterized hallmark of cancer. On the basis of our recent findings of lipidomic changes in breast cancer, we investigated glycerol-3-phosphate acyltransferase (GPAM), a key enzyme in the lipid biosynthesis of triacylglycerols and phospholipids. GPAM protein expression was evaluated and linked to metabolomic and lipidomic profiles in a cohort of human breast carcinomas. In addition, GPAM mRNA expression was analyzed using the GeneSapiens in silico transcriptiomics database. High cytoplasmic GPAM expression was associated with hormone receptor negative status (p = 0.013). On the protein (p = 0.048) and mRNA (p = 0.001) levels, increased GPAM expression was associated with a better overall survival. Metabolomic analysis by GC-MS showed that sn-glycerol-3-phosphate, the substrate of GPAM, was elevated in breast cancer compared to normal breast tissue. LC-MS based lipidomic analysis identified significantly higher levels of phospholipids, especially phosphatidylcholines in GPAM protein positive tumors. In conclusion, our results suggest that GPAM is expressed in human breast cancer with associated changes in the cellular metabolism, in particular an increased synthesis of phospholipids, the major structural component of cellular membranes.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)

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