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Sökning: WFRF:(Luan Jian'an) > (2020-2022) > Plasma Vitamin C an...

Plasma Vitamin C and type 2 diabetes : Genome-wide association study and mendelian randomization analysis in European populations

Zheng, Ju Sheng (författare)
Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom; Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China,Westlake University
Luan, Jian’An (författare)
Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
Sofianopoulou, Eleni (författare)
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cam-bridge, United Kingdom
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Imamura, Fumiaki (författare)
Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
Stewart, Isobel D. (författare)
Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
Day, Felix R. (författare)
Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
Pietzner, Maik (författare)
Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
Wheeler, Eleanor (författare)
Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
Lotta, Luca A. (författare)
Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
Gundersen, Thomas E. (författare)
Vitas AS,Vitas Ltd, Oslo, Norway
Amiano, Pilar (författare)
Ministry of Health of the Basque Government, Public Health Division of Gipuzkoa, Biodonostia Health Research Institute, Donostia-San Sebas-tian, Spain
Ardanaz, Eva (författare)
Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; CIBER in Epidemiology and Public Health (CI-BERESP), Madrid, Spain,CIBER Epidemiology and Public Health (CIBERESP),Navarre Public Health Institute (ISPN)
Chirlaque, María Dolores (författare)
CIBER in Epidemiology and Public Health (CI-BERESP), Madrid, Spain; Department of Epidemiology, Regional Health Council, Instituto Murciano de Investigatión Bio-sanitaria (IMIB)-Arrixaca, Murcia University, Mur-cia, Spain,University of Murcia
Fagherazzi, Guy (författare)
Digital Epidemiology and e-Health Research Hub, Department of Population Health, Luxembourg Institute of Health, Strassen, Luxembourg, France; Center of Epidemiology and Population Health, UMR 1018, INSERM, Paris South-Paris Saclay University, Gustave Roussy Institute, Villejuif, France,University of Paris-Saclay,Luxembourg Institute of Health
Franks, Paul W. (författare)
Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Department of Clinical Sciences, Lund Univer-sity, Malmö, Sweden
Kaaks, Rudolf (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Laouali, Nasser (författare)
Center of Epidemiology and Population Health, UMR 1018, INSERM, Paris South-Paris Saclay University, Gustave Roussy Institute, Villejuif, France,University of Paris-Saclay
Mancini, Francesca Romana (författare)
Center of Epidemiology and Population Health, UMR 1018, INSERM, Paris South-Paris Saclay University, Gustave Roussy Institute, Villejuif, France,Institut Gustave Roussy
Nilsson, Peter M. (författare)
Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Department of Clinical Sciences, Lund Univer-sity, Malmö, Sweden
Charlotte Onland-Moret, N. (författare)
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands,University Medical Center Utrecht
Olsen, Anja (författare)
Danish Cancer Society Research Center, Copen-hagen, Denmark; Department of Public Health, Aarhus Univer-sity, Aarhus, Denmark,Aarhus University
Overvad, Kim (författare)
Department of Public Health, Aarhus Univer-sity, Aarhus, Denmark; Department of Cardiology, Aalborg University Hospital, Aarhus, Denmark,Aarhus University
Panico, Salvatore (författare)
Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
Palli, Domenico (författare)
Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network-ISPRO, Florence, Italy
Ricceri, Fulvio (författare)
Department of Clinical and Biological Sciences, University of Turin, Turin, Orbassano, Italy; Unit of Epidemiology, Regional Health Service ASL TO3, Turin, Grugliasco, Italy,Azienda Sanitaria Locale Torino 3
Rolandsson, Olov (författare)
Umeå universitet,Umeå University,Allmänmedicin
Spijkerman, Annemieke M.W. (författare)
National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands
Sánchez, María José (författare)
Andalusian School Of Public Health (EASP),Andalusian School of Public Health, Granada, Spain
Schulze, Matthias B. (författare)
Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany; Institute of Nutrition Science, University of Potsdam, Nuthetal, Germany,University of Potsdam,German Center for Diabetes Research
Sala, Núria (författare)
Unit of Nutrition and Cancer, Cancer Epidemiology Research Program and Translational Research Laboratory, Catalan Institute of Oncology-ICO, Group of Research on Nutrition and Cancer, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet of Llobregat, Barcelona, Spain,Catalan Institute of Oncology,L'Hospitalet de Llobregat, Barcelona
Sieri, Sabina (författare)
Epidemiology and Prevention Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori di Milano Via Venezian, Milan, Italy,British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cam-bridge, United Kingdom; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom; National Institute for Health Research Cambridge Biomedical Research Center, University of Cambridge and Cambridge University Hospitals, Cambridge, United Kingdom; Health Data Research UK Cambridge, Well-come Genome Campus and University of Cam-bridge, Cambridge, United Kingdom,Wellcome Trust Sanger Institute
Tjønneland, Anne (författare)
Department of Public Health, Aarhus Univer-sity, Aarhus, Denmark; Institute of Public Health, University of Copen-hagen, Copenhagen, Denmark,Aarhus University
Tumino, Rosario (författare)
Civic and M.P Arezzo Hospital,Cancer Registry and Histopathology Depart-ment, Azienda Sanitaria Provinciale (ASP), Ra-gusa, Italy
van der Schouw, Yvonne T. (författare)
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands,University Medical Center Utrecht
Weiderpass, Elisabete (författare)
International Agency for Research on Cancer, World Health Organization,International Agency for Research on Cancer, Lyon, France
Riboli, Elio (författare)
School of Public Health, Imperial College, London, United Kingdom
Danesh, John (författare)
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cam-bridge, United Kingdom; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom; British Heart Foundation Center of Research Excellence, University of Cambridge, Cambridge, United Kingdom; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom; National Institute for Health Research Cambridge Biomedical Research Center, University of Cambridge and Cambridge University Hospitals, Cambridge, United Kingdom; Health Data Research UK Cambridge, Well-come Genome Campus and University of Cam-bridge, Cambridge, United Kingdom,Wellcome Trust Sanger Institute
Butterworth, Adam S. (författare)
Wellcome Trust Sanger Institute,University of Cambridge
Sharp, Stephen J. (författare)
Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
Langenberg, Claudia (författare)
Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
Forouhi, Nita G. (författare)
Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
Wareham, Nicholas J. (författare)
Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
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 (creator_code:org_t)
2020-11-17
2021
Engelska 9 s.
Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 44:1, s. 98-106
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • OBJECTIVE Higher plasma vitamin C levels are associated with lower type 2 diabetes risk, but whether this association is causal is uncertain. To investigate this, we studied the association of genetically predicted plasma vitamin C with type 2 diabetes. RESEARCH DESIGN AND METHODS We conducted genome-wide association studies of plasma vitamin C among 52,018 individuals of European ancestry to discover novel genetic variants. We performed Mendelian randomization analyses to estimate the association of genetically predicted differences in plasma vitamin C with type 2 diabetes in up to 80,983 case participants and 842,909 noncase participants. We compared this estimate with the observational association between plasma vitamin C and incident type 2 diabetes, including 8,133 case participants and 11,073 noncase participants. RESULTS We identified 11 genomic regions associated with plasma vitamin C (P < 5 ☓ 10-8), with the strongest signal at SLC23A1, and 10 novel genetic loci including SLC23A3, CHPT1, BCAS3, SNRPF, RER1, MAF, GSTA5, RGS14, AKT1, and FADS1. Plasma vitamin C was inversely associated with type 2 diabetes (hazard ratio per SD 0.88; 95% CI 0.82, 0.94), but there was no association between genetically predicted plasma vitamin C (excluding FADS1 variant due to its apparent pleiotropic effect) and type 2 diabetes (1.03; 95% CI 0.96, 1.10). CONCLUSIONS These findings indicate discordance between biochemically measured and genetically predicted plasma vitamin C levels in the association with type 2 diabetes among European populations. The null Mendelian randomization findings provide no strong evidence to suggest the use of vitamin C supplementation for type 2 diabetes prevention.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

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