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Search: WFRF:(Luben R) > (2010-2014) > Association analyse...

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Speliotes, Elizabeth K. (author)
Willer, Cristen J. (author)
Berndt, Sonja I. (author)
show more...
Monda, Keri L. (author)
Thorleifsson, Gudmar (author)
Jackson, Anne U. (author)
Allen, Hana Lango (author)
Lindgren, Cecilia M. (author)
Luan, Jian'an (author)
Maegi, Reedik (author)
Randall, Joshua C. (author)
Vedantam, Sailaja (author)
Winkler, Thomas W. (author)
Qi, Lu (author)
Workalemahu, Tsegaselassie (author)
Heid, Iris M. (author)
Steinthorsdottir, Valgerdur (author)
Stringham, Heather M. (author)
Weedon, Michael N. (author)
Wheeler, Eleanor (author)
Wood, Andrew R. (author)
Ferreira, Teresa (author)
Weyant, Robert J. (author)
Segre, Ayellet V. (author)
Estrada, Karol (author)
Liang, Liming (author)
Nemesh, James (author)
Park, Ju-Hyun (author)
Gustafsson, Stefan (author)
Kilpelaenen, Tuomas O. (author)
Yang, Jian (author)
Bouatia-Naji, Nabila (author)
Esko, Tonu (author)
Feitosa, Mary F. (author)
Kutalik, Zoltan (author)
Mangino, Massimo (author)
Raychaudhuri, Soumya (author)
Scherag, Andre (author)
Smith, Albert Vernon (author)
Welch, Ryan (author)
Zhao, Jing Hua (author)
Aben, Katja K. (author)
Absher, Devin M. (author)
Amin, Najaf (author)
Dixon, Anna L. (author)
Fisher, Eva (author)
Glazer, Nicole L. (author)
Goddard, Michael E. (author)
Heard-Costa, Nancy L. (author)
Hoesel, Volker (author)
Hottenga, Jouke-Jan (author)
Johansson, Åsa (author)
Uppsala universitet,Institutionen för genetik och patologi
Johnson, Toby (author)
Ketkar, Shamika (author)
Lamina, Claudia (author)
Li, Shengxu (author)
Moffatt, Miriam F. (author)
Myers, Richard H. (author)
Narisu, Narisu (author)
Perry, John R. B. (author)
Peters, Marjolein J. (author)
Preuss, Michael (author)
Ripatti, Samuli (author)
Rivadeneira, Fernando (author)
Sandholt, Camilla (author)
Scott, Laura J. (author)
Timpson, Nicholas J. (author)
Tyrer, Jonathan P. (author)
van Wingerden, Sophie (author)
Watanabe, Richard M. (author)
White, Charles C. (author)
Wiklund, Fredrik (author)
Karolinska Institutet
Barlassina, Christina (author)
Chasman, Daniel I. (author)
Cooper, Matthew N. (author)
Jansson, John-Olov, 1954 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
Lawrence, Robert W. (author)
Pellikka, Niina (author)
Prokopenko, Inga (author)
Shi, Jianxin (author)
Thiering, Elisabeth (author)
Alavere, Helene (author)
Alibrandi, Maria T. S. (author)
Almgren, Peter (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Arnold, Alice M. (author)
Aspelund, Thor (author)
Atwood, Larry D. (author)
Balkau, Beverley (author)
Balmforth, Anthony J. (author)
Bennett, Amanda J. (author)
Ben-Shlomo, Yoav (author)
Bergman, Richard N. (author)
Bergmann, Sven (author)
Biebermann, Heike (author)
Blakemore, Alexandra I. F. (author)
Boes, Tanja (author)
Bonnycastle, Lori L. (author)
Bornstein, Stefan R. (author)
Brown, Morris J. (author)
Buchanan, Thomas A. (author)
Busonero, Fabio (author)
Campbell, Harry (author)
Cappuccio, Francesco P. (author)
Cavalcanti-Proenca, Christine (author)
Chen, Yii-Der Ida (author)
Chen, Chih-Mei (author)
Chines, Peter S. (author)
Clarke, Robert (author)
Coin, Lachlan (author)
Connell, John (author)
Day, Ian N. M. (author)
den Heijer, Martin (author)
Duan, Jubao (author)
Ebrahim, Shah (author)
Elliott, Paul (author)
Elosua, Roberto (author)
Eiriksdottir, Gudny (author)
Erdos, Michael R. (author)
Eriksson, Johan G. (author)
Facheris, Maurizio F. (author)
Felix, Stephan B. (author)
Fischer-Posovszky, Pamela (author)
Folsom, Aaron R. (author)
Friedrich, Nele (author)
Freimer, Nelson B. (author)
Fu, Mao (author)
Gaget, Stefan (author)
Gejman, Pablo V. (author)
Geus, Eco J. C. (author)
Gieger, Christian (author)
Gjesing, Anette P. (author)
Goel, Anuj (author)
Goyette, Philippe (author)
Grallert, Harald (author)
Graessler, Juergen (author)
Greenawalt, Danielle M. (author)
Groves, Christopher J. (author)
Gudnason, Vilmundur (author)
Guiducci, Candace (author)
Hartikainen, Anna-Liisa (author)
Hassanali, Neelam (author)
Hall, Alistair S. (author)
Havulinna, Aki S. (author)
Hayward, Caroline (author)
Heath, Andrew C. (author)
Hengstenberg, Christian (author)
Hicks, Andrew A. (author)
Hinney, Anke (author)
Hofman, Albert (author)
Homuth, Georg (author)
Hui, Jennie (author)
Igl, Wilmar (author)
Uppsala universitet,Institutionen för genetik och patologi
Iribarren, Carlos (author)
Isomaa, Bo (author)
Jacobs, Kevin B. (author)
Jarick, Ivonne (author)
Jewell, Elizabeth (author)
John, Ulrich (author)
Jorgensen, Torben (author)
Jousilahti, Pekka (author)
Jula, Antti (author)
Kaakinen, Marika (author)
Kajantie, Eero (author)
Kaplan, Lee M. (author)
Kathiresan, Sekar (author)
Kettunen, Johannes (author)
Kinnunen, Leena (author)
Knowles, Joshua W. (author)
Kolcic, Ivana (author)
Koenig, Inke R. (author)
Koskinen, Seppo (author)
Kovacs, Peter (author)
Kuusisto, Johanna (author)
Kraft, Peter (author)
Kvaloy, Kirsti (author)
Laitinen, Jaana (author)
Lantieri, Olivier (author)
Lanzani, Chiara (author)
Launer, Lenore J. (author)
Lecoeur, Cecile (author)
Lehtimaeki, Terho (author)
Lettre, Guillaume (author)
Liu, Jianjun (author)
Lokki, Marja-Liisa (author)
Lorentzon, Mattias, 1970 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
Luben, Robert N. (author)
Ludwig, Barbara (author)
Manunta, Paolo (author)
Marek, Diana (author)
Marre, Michel (author)
Martin, Nicholas G. (author)
McArdle, Wendy L. (author)
McCarthy, Anne (author)
McKnight, Barbara (author)
Meitinger, Thomas (author)
Melander, Olle (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Meyre, David (author)
Midthjell, Kristian (author)
Montgomery, Grant W. (author)
Morken, Mario A. (author)
Morris, Andrew P. (author)
Mulic, Rosanda (author)
Ngwa, Julius S. (author)
Nelis, Mari (author)
Neville, Matt J. (author)
Nyholt, Dale R. (author)
O'Donnell, Christopher J. (author)
O'Rahilly, Stephen (author)
Ong, Ken K. (author)
Oostra, Ben (author)
Pare, Guillaume (author)
Parker, Alex N. (author)
Perola, Markus (author)
Pichler, Irene (author)
Pietilaeinen, Kirsi H. (author)
Karolinska Institutet
Platou, Carl G. P. (author)
Polasek, Ozren (author)
Pouta, Anneli (author)
Rafelt, Suzanne (author)
Raitakari, Olli (author)
Rayner, Nigel W. (author)
Ridderstråle, Martin (author)
Lund University,Lunds universitet,Diabetes - klinisk obesitasforskning,Forskargrupper vid Lunds universitet,Diabetes - Clinical Obesity,Lund University Research Groups
Rief, Winfried (author)
Ruokonen, Aimo (author)
Robertson, Neil R. (author)
Rzehak, Peter (author)
Salomaa, Veikko (author)
Sanders, Alan R. (author)
Sandhu, Manjinder S. (author)
Sanna, Serena (author)
Saramies, Jouko (author)
Savolainen, Markku J. (author)
Scherag, Susann (author)
Schipf, Sabine (author)
Schreiber, Stefan (author)
Schunkert, Heribert (author)
Silander, Kaisa (author)
Sinisalo, Juha (author)
Siscovick, David S. (author)
Smit, Jan H. (author)
Soranzo, Nicole (author)
Sovio, Ulla (author)
Stephens, Jonathan (author)
Surakka, Ida (author)
Swift, Amy J. (author)
Tammesoo, Mari-Liis (author)
Tardif, Jean-Claude (author)
Teder-Laving, Maris (author)
Teslovich, Tanya M. (author)
Thompson, John R. (author)
Thomson, Brian (author)
Toenjes, Anke (author)
Tuomi, Tiinamaija (author)
van Meurs, Joyce B. J. (author)
van Ommen, Gert-Jan (author)
Vatin, Vincent (author)
Viikari, Jorma (author)
Visvikis-Siest, Sophie (author)
Vitart, Veronique (author)
Vogel, Carla I. G. (author)
Voight, Benjamin F. (author)
Waite, Lindsay L. (author)
Wallaschofski, Henri (author)
Walters, G. Bragi (author)
Widen, Elisabeth (author)
Wiegand, Susanna (author)
Wild, Sarah H. (author)
Willemsen, Gonneke (author)
Witte, Daniel R. (author)
Witteman, Jacqueline C. (author)
Xu, Jianfeng (author)
Zhang, Qunyuan (author)
Zgaga, Lina (author)
Ziegler, Andreas (author)
Zitting, Paavo (author)
Beilby, John P. (author)
Farooqi, I. Sadaf (author)
Hebebrand, Johannes (author)
Huikuri, Heikki V. (author)
James, Alan L. (author)
Kaehoenen, Mika (author)
Levinson, Douglas F. (author)
Macciardi, Fabio (author)
Nieminen, Markku S. (author)
Ohlsson, Claes, 1965 (author)
Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
Palmer, Lyle J. (author)
Ridker, Paul M. (author)
Stumvoll, Michael (author)
Beckmann, Jacques S. (author)
Boeing, Heiner (author)
Boerwinkle, Eric (author)
Boomsma, Dorret I. (author)
Caulfield, Mark J. (author)
Chanock, Stephen J. (author)
Collins, Francis S. (author)
Cupples, L. Adrienne (author)
Smith, George Davey (author)
Erdmann, Jeanette (author)
Froguel, Philippe (author)
Greonberg, Henrik (author)
Karolinska Institutet
Gyllensten, Ulf (author)
Uppsala universitet,Institutionen för genetik och patologi
Hall, Per (author)
Hansen, Torben (author)
Harris, Tamara B. (author)
Hattersley, Andrew T. (author)
Hayes, Richard B. (author)
Heinrich, Joachim (author)
Hu, Frank B. (author)
Hveem, Kristian (author)
Illig, Thomas (author)
Jarvelin, Marjo-Riitta (author)
Kaprio, Jaakko (author)
Karpe, Fredrik (author)
Khaw, Kay-Tee (author)
Kiemeney, Lambertus A. (author)
Krude, Heiko (author)
Laakso, Markku (author)
Lawlor, Debbie A. (author)
Metspalu, Andres (author)
Munroe, Patricia B. (author)
Ouwehand, Willem H. (author)
Pedersen, Oluf (author)
Penninx, Brenda W. (author)
Peters, Annette (author)
Pramstaller, Peter P. (author)
Quertermous, Thomas (author)
Reinehr, Thomas (author)
Rissanen, Aila (author)
Rudan, Igor (author)
Samani, Nilesh J. (author)
Schwarz, Peter E. H. (author)
Shuldiner, Alan R. (author)
Spector, Timothy D. (author)
Tuomilehto, Jaakko (author)
Uda, Manuela (author)
Uitterlinden, Andre (author)
Valle, Timo T. (author)
Wabitsch, Martin (author)
Waeber, Gerard (author)
Wareham, Nicholas J. (author)
Watkins, Hugh (author)
Wilson, James F. (author)
Wright, Alan F. (author)
Zillikens, M. Carola (author)
Chatterjee, Nilanjan (author)
McCarroll, Steven A. (author)
Purcell, Shaun (author)
Schadt, Eric E. (author)
Visscher, Peter M. (author)
Assimes, Themistocles L. (author)
Borecki, Ingrid B. (author)
Deloukas, Panos (author)
Fox, Caroline S. (author)
Groop, Leif (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Haritunians, Talin (author)
Hunter, David J. (author)
Kaplan, Robert C. (author)
Mohlke, Karen L. (author)
O'Connell, Jeffrey R. (author)
Peltonen, Leena (author)
Schlessinger, David (author)
Strachan, David P. (author)
van Duijn, Cornelia M. (author)
Wichmann, H-Erich (author)
Frayling, Timothy M. (author)
Thorsteinsdottir, Unnur (author)
Abecasis, Goncalo R. (author)
Barroso, Ines (author)
Boehnke, Michael (author)
Stefansson, Kari (author)
North, Kari E. (author)
McCarthy, Mark I. (author)
Hirschhorn, Joel N. (author)
Ingelsson, Erik (author)
Karolinska Institutet
Loos, Ruth J. F. (author)
Gräßler, Jürgen (author)
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 (creator_code:org_t)
2010-10-10
2010
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 937-948
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Physiology (hsv//eng)

Keyword

MEDICINE
MEDICIN

Publication and Content Type

ref (subject category)
art (subject category)

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Speliotes, Eliza ...
Willer, Cristen ...
Berndt, Sonja I.
Monda, Keri L.
Thorleifsson, Gu ...
Jackson, Anne U.
show more...
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Chines, Peter S.
Clarke, Robert
Coin, Lachlan
Connell, John
Day, Ian N. M.
den Heijer, Mart ...
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Ebrahim, Shah
Elliott, Paul
Elosua, Roberto
Eiriksdottir, Gu ...
Erdos, Michael R ...
Eriksson, Johan ...
Facheris, Mauriz ...
Felix, Stephan B ...
Fischer-Posovszk ...
Folsom, Aaron R.
Friedrich, Nele
Freimer, Nelson ...
Fu, Mao
Gaget, Stefan
Gejman, Pablo V.
Geus, Eco J. C.
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Sovio, Ulla
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Farooqi, I. Sada ...
Hebebrand, Johan ...
Huikuri, Heikki ...
James, Alan L.
Kaehoenen, Mika
Levinson, Dougla ...
Macciardi, Fabio
Nieminen, Markku ...
Ohlsson, Claes, ...
Palmer, Lyle J.
Ridker, Paul M.
Stumvoll, Michae ...
Beckmann, Jacque ...
Boeing, Heiner
Boerwinkle, Eric
Boomsma, Dorret ...
Caulfield, Mark ...
Chanock, Stephen ...
Collins, Francis ...
Cupples, L. Adri ...
Smith, George Da ...
Erdmann, Jeanett ...
Froguel, Philipp ...
Greonberg, Henri ...
Gyllensten, Ulf
Hall, Per
Hansen, Torben
Harris, Tamara B ...
Hattersley, Andr ...
Hayes, Richard B ...
Heinrich, Joachi ...
Hu, Frank B.
Hveem, Kristian
Illig, Thomas
Jarvelin, Marjo- ...
Kaprio, Jaakko
Karpe, Fredrik
Khaw, Kay-Tee
Kiemeney, Lamber ...
Krude, Heiko
Laakso, Markku
Lawlor, Debbie A ...
Metspalu, Andres
Munroe, Patricia ...
Ouwehand, Willem ...
Pedersen, Oluf
Penninx, Brenda ...
Peters, Annette
Pramstaller, Pet ...
Quertermous, Tho ...
Reinehr, Thomas
Rissanen, Aila
Rudan, Igor
Samani, Nilesh J ...
Schwarz, Peter E ...
Shuldiner, Alan ...
Spector, Timothy ...
Tuomilehto, Jaak ...
Uda, Manuela
Uitterlinden, An ...
Valle, Timo T.
Wabitsch, Martin
Waeber, Gerard
Wareham, Nichola ...
Watkins, Hugh
Wilson, James F.
Wright, Alan F.
Zillikens, M. Ca ...
Chatterjee, Nila ...
McCarroll, Steve ...
Purcell, Shaun
Schadt, Eric E.
Visscher, Peter ...
Assimes, Themist ...
Borecki, Ingrid ...
Deloukas, Panos
Fox, Caroline S.
Groop, Leif
Haritunians, Tal ...
Hunter, David J.
Kaplan, Robert C ...
Mohlke, Karen L.
O'Connell, Jeffr ...
Peltonen, Leena
Schlessinger, Da ...
Strachan, David ...
van Duijn, Corne ...
Wichmann, H-Eric ...
Frayling, Timoth ...
Thorsteinsdottir ...
Abecasis, Goncal ...
Barroso, Ines
Boehnke, Michael
Stefansson, Kari
North, Kari E.
McCarthy, Mark I ...
Hirschhorn, Joel ...
Ingelsson, Erik
Loos, Ruth J. F.
Gräßler, Jürgen
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cardiac and Card ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Health Sciences
and Nutrition and Di ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Endocrinology an ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Physiology
Articles in the publication
Nature Genetics
By the university
Uppsala University
Lund University
University of Gothenburg
Karolinska Institutet

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