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Search: WFRF:(Luben R) > (2005-2009) > Six new loci associ...

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

Willer, Cristen J. (author)
Speliotes, Elizabeth K. (author)
Loos, Ruth J. F. (author)
show more...
Li, Shengxu (author)
Lindgren, Cecilia M. (author)
Heid, Iris M. (author)
Berndt, Sonja I. (author)
Elliott, Amanda L. (author)
Jackson, Anne U. (author)
Lamina, Claudia (author)
Lettre, Guillaume (author)
Lim, Noha (author)
Lyon, Helen N. (author)
McCarroll, Steven A. (author)
Papadakis, Konstantinos (author)
Qi, Lu (author)
Randall, Joshua C. (author)
Roccasecca, Rosa Maria (author)
Sanna, Serena (author)
Scheet, Paul (author)
Weedon, Michael N. (author)
Wheeler, Eleanor (author)
Zhao, Jing Hua (author)
Jacobs, Leonie C. (author)
Prokopenko, Inga (author)
Soranzo, Nicole (author)
Tanaka, Toshiko (author)
Timpson, Nicholas J. (author)
Almgren, Peter (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Bennett, Amanda (author)
Bergman, Richard N. (author)
Bingham, Sheila A. (author)
Bonnycastle, Lori L. (author)
Brown, Morris (author)
Burtt, Noel L. P. (author)
Chines, Peter (author)
Coin, Lachlan (author)
Collins, Francis S. (author)
Connell, John M. (author)
Cooper, Cyrus (author)
Smith, George Davey (author)
Dennison, Elaine M. (author)
Deodhar, Parimal (author)
Elliott, Paul (author)
Erdos, Michael R. (author)
Estrada, Karol (author)
Evans, David M. (author)
Gianniny, Lauren (author)
Gieger, Christian (author)
Gillson, Christopher J. (author)
Guiducci, Candace (author)
Hackett, Rachel (author)
Hadley, David (author)
Hall, Alistair S. (author)
Havulinna, Aki S. (author)
Hebebrand, Johannes (author)
Hofman, Albert (author)
Isomaa, Bo (author)
Jacobs, Kevin B. (author)
Johnson, Toby (author)
Jousilahti, Pekka (author)
Jovanovic, Zorica (author)
Khaw, Kay-Tee (author)
Kraft, Peter (author)
Kuokkanen, Mikko (author)
Kuusisto, Johanna (author)
Laitinen, Jaana (author)
Lakatta, Edward G. (author)
Luan, Jian'an (author)
Luben, Robert N. (author)
Mangino, Massimo (author)
McArdle, Wendy L. (author)
Meitinger, Thomas (author)
Mulas, Antonella (author)
Munroe, Patricia B. (author)
Narisu, Narisu (author)
Ness, Andrew R. (author)
Northstone, Kate (author)
O'Rahilly, Stephen (author)
Purmann, Carolin (author)
Rees, Matthew G. (author)
Ridderstråle, Martin (author)
Lund University,Lunds universitet,Diabetes - klinisk obesitasforskning,Forskargrupper vid Lunds universitet,Diabetes - Clinical Obesity,Lund University Research Groups
Ring, Susan M. (author)
Rivadeneira, Fernando (author)
Ruokonen, Aimo (author)
Sandhu, Manjinder S. (author)
Saramies, Jouko (author)
Scott, Laura J. (author)
Scuteri, Angelo (author)
Silander, Kaisa (author)
Sims, Matthew A. (author)
Song, Kijoung (author)
Stephens, Jonathan (author)
Stevens, Suzanne (author)
Stringham, Heather M. (author)
Tung, Y. C. Loraine (author)
Valle, Timo T. (author)
Van Duijn, Cornelia M. (author)
Vimaleswaran, Karani S. (author)
Vollenweider, Peter (author)
Waeber, Gerard (author)
Wallace, Chris (author)
Watanabe, Richard M. (author)
Waterworth, Dawn M. (author)
Watkins, Nicholas (author)
Witteman, Jacqueline C. M. (author)
Zeggini, Eleftheria (author)
Zhai, Guangju (author)
Zillikens, M. Carola (author)
Altshuler, David (author)
Caulfield, Mark J. (author)
Chanock, Stephen J. (author)
Farooqi, I. Sadaf (author)
Ferrucci, Luigi (author)
Guralnik, Jack M. (author)
Hattersley, Andrew T. (author)
Hu, Frank B. (author)
Jarvelin, Marjo-Riitta (author)
Laakso, Markku (author)
Mooser, Vincent (author)
Ong, Ken K. (author)
Ouwehand, Willem H. (author)
Salomaa, Veikko (author)
Samani, Nilesh J. (author)
Spector, Timothy D. (author)
Tuomi, Tiinamaija (author)
Tuomilehto, Jaakko (author)
Uda, Manuela (author)
Uitterlinden, Andre G. (author)
Wareham, Nicholas J. (author)
Deloukas, Panagiotis (author)
Frayling, Timothy M. (author)
Groop, Leif (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Hayes, Richard B. (author)
Hunter, David J. (author)
Mohlke, Karen L. (author)
Peltonen, Leena (author)
Schlessinger, David (author)
Strachan, David P. (author)
Wichmann, H-Erich (author)
McCarthy, Mark I. (author)
Boehnke, Michael (author)
Barroso, Ines (author)
Abecasis, Goncalo R. (author)
Hirschhorn, Joel N. (author)
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 (creator_code:org_t)
2008-12-14
2009
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:1, s. 25-34
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

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art (subject category)
ref (subject category)

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By the author/editor
Willer, Cristen ...
Speliotes, Eliza ...
Loos, Ruth J. F.
Li, Shengxu
Lindgren, Cecili ...
Heid, Iris M.
show more...
Berndt, Sonja I.
Elliott, Amanda ...
Jackson, Anne U.
Lamina, Claudia
Lettre, Guillaum ...
Lim, Noha
Lyon, Helen N.
McCarroll, Steve ...
Papadakis, Konst ...
Qi, Lu
Randall, Joshua ...
Roccasecca, Rosa ...
Sanna, Serena
Scheet, Paul
Weedon, Michael ...
Wheeler, Eleanor
Zhao, Jing Hua
Jacobs, Leonie C ...
Prokopenko, Inga
Soranzo, Nicole
Tanaka, Toshiko
Timpson, Nichola ...
Almgren, Peter
Bennett, Amanda
Bergman, Richard ...
Bingham, Sheila ...
Bonnycastle, Lor ...
Brown, Morris
Burtt, Noel L. P ...
Chines, Peter
Coin, Lachlan
Collins, Francis ...
Connell, John M.
Cooper, Cyrus
Smith, George Da ...
Dennison, Elaine ...
Deodhar, Parimal
Elliott, Paul
Erdos, Michael R ...
Estrada, Karol
Evans, David M.
Gianniny, Lauren
Gieger, Christia ...
Gillson, Christo ...
Guiducci, Candac ...
Hackett, Rachel
Hadley, David
Hall, Alistair S ...
Havulinna, Aki S ...
Hebebrand, Johan ...
Hofman, Albert
Isomaa, Bo
Jacobs, Kevin B.
Johnson, Toby
Jousilahti, Pekk ...
Jovanovic, Zoric ...
Khaw, Kay-Tee
Kraft, Peter
Kuokkanen, Mikko
Kuusisto, Johann ...
Laitinen, Jaana
Lakatta, Edward ...
Luan, Jian'an
Luben, Robert N.
Mangino, Massimo
McArdle, Wendy L ...
Meitinger, Thoma ...
Mulas, Antonella
Munroe, Patricia ...
Narisu, Narisu
Ness, Andrew R.
Northstone, Kate
O'Rahilly, Steph ...
Purmann, Carolin
Rees, Matthew G.
Ridderstråle, Ma ...
Ring, Susan M.
Rivadeneira, Fer ...
Ruokonen, Aimo
Sandhu, Manjinde ...
Saramies, Jouko
Scott, Laura J.
Scuteri, Angelo
Silander, Kaisa
Sims, Matthew A.
Song, Kijoung
Stephens, Jonath ...
Stevens, Suzanne
Stringham, Heath ...
Tung, Y. C. Lora ...
Valle, Timo T.
Van Duijn, Corne ...
Vimaleswaran, Ka ...
Vollenweider, Pe ...
Waeber, Gerard
Wallace, Chris
Watanabe, Richar ...
Waterworth, Dawn ...
Watkins, Nichola ...
Witteman, Jacque ...
Zeggini, Elefthe ...
Zhai, Guangju
Zillikens, M. Ca ...
Altshuler, David
Caulfield, Mark ...
Chanock, Stephen ...
Farooqi, I. Sada ...
Ferrucci, Luigi
Guralnik, Jack M ...
Hattersley, Andr ...
Hu, Frank B.
Jarvelin, Marjo- ...
Laakso, Markku
Mooser, Vincent
Ong, Ken K.
Ouwehand, Willem ...
Salomaa, Veikko
Samani, Nilesh J ...
Spector, Timothy ...
Tuomi, Tiinamaij ...
Tuomilehto, Jaak ...
Uda, Manuela
Uitterlinden, An ...
Wareham, Nichola ...
Deloukas, Panagi ...
Frayling, Timoth ...
Groop, Leif
Hayes, Richard B ...
Hunter, David J.
Mohlke, Karen L.
Peltonen, Leena
Schlessinger, Da ...
Strachan, David ...
Wichmann, H-Eric ...
McCarthy, Mark I ...
Boehnke, Michael
Barroso, Ines
Abecasis, Goncal ...
Hirschhorn, Joel ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Endocrinology an ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Health Sciences
and Nutrition and Di ...
Articles in the publication
Nature Genetics
By the university
Lund University

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