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The Association bet...
The Association between Serum Lipids and Intraocular Pressure in 2 Large United Kingdom Cohorts
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- Madjedi, Kian M. (author)
- NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK; Department of Ophthalmology, University of Calgary, Alberta, Canada
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- Stuart, Kelsey V. (author)
- NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK
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- Chua, Sharon Y. L. (author)
- NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK
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- Luben, Robert N. (author)
- NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK
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- Warwick, Alasdair (author)
- UCL Institute of Cardiovascular Science, London, United Kingdom
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- Pasquale, Louis R. (author)
- Icahn School of Medicine at Mount Sinai, Department of Ophthalmology, New York, NY, USA
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- Kang, Jae H. (author)
- Brigham and Women's Hospital / Harvard Medical School, Boston, MA, USA
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- Wiggs, Janey L. (author)
- Department of Ophthalmology, Harvard Medical School, Boston, MA, USA
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- Lentjes, Marleen, 1974- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics; Nutrient Gut-Brain Interaction
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- Aschard, Hugues (author)
- Institute Pasteur, Paris, France
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- Sattar, Naveed (author)
- BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
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- Foster, Paul J. (author)
- NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK
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- Khawaja, Anthony P. (author)
- NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK
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Modifiable Risk Factors for Glaucoma Collaboration and the UK Biobank Eye and Vision Consortium, - (contributor)
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: Ophthalmology. - : Elsevier. - 0161-6420 .- 1549-4713. ; 129:9, s. 986-996
- Related links:
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https://doi.org/10.1...
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Abstract
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- PURPOSE: Serum lipids are modifiable, routinely collected blood tests associated with cardiovascular health. We examined the association of commonly collected serum lipid measures (total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL-C) and triglycerides (TG)) with intraocular pressure (IOP).DESIGN: Cross-sectional study in the UK Biobank and EPIC-Norfolk cohorts.PARTICIPANTS: We included 94 323 participants of UK Biobank (mean age 57 years) and 6 230 participants of EPIC-Norfolk (mean age 68 years) with data on TC, HDL-C, LDL-C, TG collected between 2006-2009.METHODS: Multivariable linear regression adjusting for demographic, lifestyle, anthropometric, medical and ophthalmic covariables was used to examine the associations of serum lipids with IOPcc.MAIN OUTCOME MEASURES: IOPcc.RESULTS: Higher levels of TC, HDL-C and LDL-C were independently associated with higher IOPcc in both cohorts after adjustment for key demographic, medical and lifestyle factors. For each standard deviation increase in TC, HDL-C, and LDL-C, IOPcc (mmHg) was higher by 0.09 (95% CI: 0.06-0.11; P<0.001), 0.11 (95% CI 0.08-0.13; P<0.001), 0.07 (95% CI: 0.05-0.09, P<0.001), respectively in the UK Biobank cohort. In the EPIC-Norfolk cohort, each additional standard deviation in TC, HDL-C, and LDL-C was associated with a higher IOPcc (mmHg) by 0.19 (95% CI 0.07-0.31, P=0.001), 0.14 (95% CI 0.03-0.25, P=0.016), and 0.17 (95% CI 0.06-0.29, P=0.003). An inverse association between TGs and IOP in the UK Biobank (-0.05, 95% CI -0.08 to -0.03, P<0.001) was not replicated in the EPIC cohort (P=0.30).CONCLUSION: Our findings suggest that serum TC, HDL-C and LDL-C are positively associated with IOP in two UK cohorts and TGs may be negatively associated. Future research is required to assess whether these associations are causal in nature.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Glaucoma
- cholesterol
- intraocular pressure
- lipids
Publication and Content Type
- ref (subject category)
- art (subject category)
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Madjedi, Kian M.
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Stuart, Kelsey V ...
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Chua, Sharon Y. ...
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Luben, Robert N.
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Warwick, Alasdai ...
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Pasquale, Louis ...
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Kang, Jae H.
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Wiggs, Janey L.
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Lentjes, Marleen ...
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Aschard, Hugues
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Sattar, Naveed
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Foster, Paul J.
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Khawaja, Anthony ...
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Modifiable Risk ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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- Articles in the publication
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Ophthalmology
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Örebro University