Sökning: WFRF:(Lundell M) >
Morbidity and morta...
Morbidity and mortality after surgery for cancer of the oesophagus and astro-oesophageal junction : a randomized clinical trial of neoadjuvant hemotherapy vs. neoadjuvant chemoradiation
-
- Klevebro, F. (författare)
- Karolinska Institutet
-
- Johnsen, G. (författare)
- Dept Gastrointestinal Surg, St Olavs Hosp, Univ Trondheim Hosp, Trondheim, Norway
-
- Johnson, E. (författare)
- Dept Paediat & Gastrointestinal Surg, Ullevaal Univ Hosp, Oslo, Norway
-
visa fler...
-
- Viste, A. (författare)
- Dept Paediat & Gastrointestinal Surg, Ullevaal Univ Hosp, Oslo, Norway
-
- Myrnäs, T. (författare)
- Dept Surg, Univ Umeå Hosp, Umeå, Sweden
-
- Szabo, Eva (författare)
- Region Örebro län,Dept Surg, Örebro University Hospital, Örebro, Sweden
-
Jacobsen, A. -B. (författare)
-
- Friesland, S. (författare)
- Karolinska Institutet
-
- Tsai, J. A. (författare)
- Karolinska Institutet
-
- Persson, S. (författare)
- Div Surg, Dept Clin Sci Intervent & Technol, Karolinska Inst, Stockholm, Sweden; Ctr Digest Dis, Karolinska Univ Hosp, Stockholm, Sweden
-
- Lindblad, M. (författare)
- Karolinska Institutet
-
- Lundell, L. (författare)
- Karolinska Institutet
-
- Nilsson, M. (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- Engelska.
-
Ingår i: European Journal of Surgical Oncology. - : Elsevier BV. - 0748-7983 .- 1532-2157. ; 41:7, s. 920-926
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objective: To compare the incidence and severity of postoperative omplications after oesophagectomy for carcinoma of the oesophagus and astro-oesophageal junction (GOJ) after randomized accrual to eoadjuvant chemotherapy (nCT) or neoadjuvant chemoradiotherapy (nCRT). ackground: Neoadjuvant therapy improves long-term survival after esophagectomy. To date, evidence is insufficient to determine whether ombined nCT, or nCRT alone, is the most beneficial. ethods: Patients with carcinoma of the oesophagus or GOJ, resectable ith a curative intention, were enrolled in this multicenter trial onducted at seven centres in Sweden and Norway. Study participants re andomized to nCT or nCRT followed by surgery with two-field ymphadenectomy. Three cycles of cisplatin/5-fluorouracil was dministered in all patients, while 40 Gy of concomitant radiotherapy as administered in the nCRT group. esults: Of the randomized 181 patients, 91 were assigned to nCT and 90 o nCRT. One-hundred-and-fifty-five patients, 78 nCT and 77 nCRT, nderwent resection. There was no statistically significant difference etween the groups in the incidence of surgical or nonsurgical omplications (P-value = 0.69 and 0.13, respectively). There was no 0-day mortality, while the 90-day mortality was 3% (2/78) in the nCT roup and 6% (5/77) in the nCRT group (P = 0.24). The median lavien-Dindo complication severity grade was significantly higher in he nCRT. group (P = 0.001). onclusion: There was no significant difference in the incidence of omplications between patients randomized to nCT and nCRT. However, omplications were significantly more severe after nCRT. Registration rial database: The trial was registered in the Clinical Trials tabase registration number NCT01362127).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Oesophageal cancer
- Neoadjuvant treatment
- Oesophagectomy complications
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Klevebro, F.
-
Johnsen, G.
-
Johnson, E.
-
Viste, A.
-
Myrnäs, T.
-
Szabo, Eva
-
visa fler...
-
Jacobsen, A. -B.
-
Friesland, S.
-
Tsai, J. A.
-
Persson, S.
-
Lindblad, M.
-
Lundell, L.
-
Nilsson, M.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kirurgi
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
European Journal ...
- Av lärosätet
-
Umeå universitet
-
Örebro universitet
-
Karolinska Institutet