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Search: WFRF:(Müller Nurasyid Martina) > (2017) > Genetic Interaction...

Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation : The AFGen Consortium

Weng, Lu Chen (author)
Broad Institute,Massachusetts General Hospital
Lunetta, Kathryn L (author)
Boston University
Müller-Nurasyid, Martina (author)
University Hospital Munich,Helmholtz Zentrum München,Ludwig-Maximilian University of Munich,German Centre for Cardiovascular Research
show more...
Smith, Albert Vernon (author)
University of Iceland,Icelandic Heart Association
Thériault, Sébastien (author)
McMaster University
Weeke, Peter E. (author)
Vanderbilt University,Copenhagen University Hospital
Barnard, John (author)
Cleveland Clinic Foundation
Bis, Joshua C. (author)
University of Washington
Lyytikäinen, Leo-Pekka (author)
University of Tampere
Kleber, Marcus E (author)
Heidelberg University
Martinsson, Andreas (author)
Lund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
Lin, Henry J. (author)
University of California, Los Angeles
Rienstra, Michiel (author)
University of Groningen
Trompet, Stella (author)
Leiden University Medical Centre
Krijthe, Bouwe P (author)
Erasmus University Medical Center
Dörr, Marcus (author)
University Medicine Greifswald,German Centre for Cardiovascular Research
Klarin, Derek (author)
Harvard University,Massachusetts General Hospital,Broad Institute
Chasman, Daniel I. (author)
Brigham and Women's Hospital / Harvard Medical School
Sinner, Moritz F (author)
Ludwig-Maximilian University of Munich,German Centre for Cardiovascular Research
Waldenberger, Melanie (author)
Helmholtz Zentrum München,German Centre for Cardiovascular Research
Launer, Lenore J. (author)
National Institute on Aging, United States
Harris, Tamara B (author)
National Institute on Aging, United States
Soliman, Elsayed Z (author)
Wake Forest University
Alonso, Alvaro (author)
Emory University
Paré, Guillaume (author)
McMaster University
Teixeira, Pedro L. (author)
Vanderbilt University
Denny, Joshua C (author)
Vanderbilt University
Shoemaker, M. Benjamin (author)
Vanderbilt University
Van Wagoner, David R (author)
Cleveland Clinic Foundation
Smith, Jonathan D (author)
Cleveland Clinic Foundation
Psaty, Bruce M. (author)
University of Washington,Kaiser Permanente Research Institute
Sotoodehnia, Nona (author)
Kaiser Permanente Research Institute,University of Washington
Taylor, Kent D (author)
University of California, Los Angeles
Kähönen, Mika (author)
Tampere University Hospital,University of Tampere
Nikus, Kjell (author)
University of Tampere,Tampere University Hospital
Delgado, Graciela E. (author)
Heidelberg University
Melander, Olle (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
Engström, Gunnar (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
Yao, Jie (author)
University of California, Los Angeles
Guo, Xiuqing (author)
University of California, Los Angeles
Christophersen, Ingrid E. (author)
Baerum Hospital,Massachusetts General Hospital,Broad Institute
Ellinor, Patrick T (author)
Massachusetts General Hospital,Broad Institute
Geelhoed, Bastiaan (author)
University of Groningen
Verweij, Niek (author)
University of Groningen
Macfarlane, Peter (author)
University of Glasgow
Ford, Ian (author)
University of Glasgow
Heeringa, Jan (author)
Erasmus University Medical Center
Franco, Oscar H (author)
Erasmus University Medical Center
Uitterlinden, André G (author)
Erasmus University Medical Center
Völker, Uwe (author)
German Centre for Cardiovascular Research,University Medicine Greifswald
Teumer, Alexander (author)
University Medicine Greifswald,German Centre for Cardiovascular Research
Rose, Lynda M. (author)
Brigham and Women's Hospital / Harvard Medical School
Kääb, Stefan (author)
Ludwig-Maximilian University of Munich,German Centre for Cardiovascular Research
Gudnason, Vilmundur (author)
University of Iceland,Icelandic Heart Association
Arking, Dan E. (author)
Johns Hopkins University
Conen, David (author)
University Hospital Basel
Roden, Dan M (author)
Vanderbilt University
Chung, Mina K (author)
Cleveland Clinic Foundation
Heckbert, Susan R (author)
Kaiser Permanente Research Institute,University of Washington
Benjamin, Emelia J (author)
Boston University
Lehtimäki, Terho (author)
University of Tampere
März, Winfried (author)
Medical University of Graz,Heidelberg University
Smith, Gustav (author)
Lund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
Rotter, Jerome I. (author)
University of California, Los Angeles
van der Harst, Pim (author)
University of Groningen
Jukema, J. Wouter (author)
Interuniversity Cardiology Institute of the Netherlands,Leiden University Medical Centre
Stricker, Bruno H (author)
Dutch Health Care Inspectorate,Erasmus University Medical Center
Felix, Stephan B (author)
German Centre for Cardiovascular Research,University Medicine Greifswald
Albert, Christine M (author)
Brigham and Women's Hospital / Harvard Medical School
Lubitz, Steven A (author)
Massachusetts General Hospital,Broad Institute
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 (creator_code:org_t)
2017-09-12
2017
English.
In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7:1
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • It is unclear whether genetic markers interact with risk factors to influence atrial fibrillation (AF) risk. We performed genome-wide interaction analyses between genetic variants and age, sex, hypertension, and body mass index in the AFGen Consortium. Study-specific results were combined using meta-analysis (88,383 individuals of European descent, including 7,292 with AF). Variants with nominal interaction associations in the discovery analysis were tested for association in four independent studies (131,441 individuals, including 5,722 with AF). In the discovery analysis, the AF risk associated with the minor rs6817105 allele (at the PITX2 locus) was greater among subjects ≤ 65 years of age than among those > 65 years (interaction p-value = 4.0 × 10-5). The interaction p-value exceeded genome-wide significance in combined discovery and replication analyses (interaction p-value = 1.7 × 10-8). We observed one genome-wide significant interaction with body mass index and several suggestive interactions with age, sex, and body mass index in the discovery analysis. However, none was replicated in the independent sample. Our findings suggest that the pathogenesis of AF may differ according to age in individuals of European descent, but we did not observe evidence of statistically significant genetic interactions with sex, body mass index, or hypertension on AF risk.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

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By the author/editor
Weng, Lu Chen
Lunetta, Kathryn ...
Müller-Nurasyid, ...
Smith, Albert Ve ...
Thériault, Sébas ...
Weeke, Peter E.
show more...
Barnard, John
Bis, Joshua C.
Lyytikäinen, Leo ...
Kleber, Marcus E
Martinsson, Andr ...
Lin, Henry J.
Rienstra, Michie ...
Trompet, Stella
Krijthe, Bouwe P
Dörr, Marcus
Klarin, Derek
Chasman, Daniel ...
Sinner, Moritz F
Waldenberger, Me ...
Launer, Lenore J ...
Harris, Tamara B
Soliman, Elsayed ...
Alonso, Alvaro
Paré, Guillaume
Teixeira, Pedro ...
Denny, Joshua C
Shoemaker, M. Be ...
Van Wagoner, Dav ...
Smith, Jonathan ...
Psaty, Bruce M.
Sotoodehnia, Non ...
Taylor, Kent D
Kähönen, Mika
Nikus, Kjell
Delgado, Graciel ...
Melander, Olle
Engström, Gunnar
Yao, Jie
Guo, Xiuqing
Christophersen, ...
Ellinor, Patrick ...
Geelhoed, Bastia ...
Verweij, Niek
Macfarlane, Pete ...
Ford, Ian
Heeringa, Jan
Franco, Oscar H
Uitterlinden, An ...
Völker, Uwe
Teumer, Alexande ...
Rose, Lynda M.
Kääb, Stefan
Gudnason, Vilmun ...
Arking, Dan E.
Conen, David
Roden, Dan M
Chung, Mina K
Heckbert, Susan ...
Benjamin, Emelia ...
Lehtimäki, Terho
März, Winfried
Smith, Gustav
Rotter, Jerome I ...
van der Harst, P ...
Jukema, J. Woute ...
Stricker, Bruno ...
Felix, Stephan B
Albert, Christin ...
Lubitz, Steven A
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cardiac and Card ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
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Scientific Repor ...
By the university
Lund University

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