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Sökning: onr:"swepub:oai:lup.lub.lu.se:6f873a72-d6db-471d-ab5f-48c956e80744" > Assessing the Costs...

Assessing the Costs of Neuropsychiatric Disease in the Systemic Lupus International Collaborating Clinics Cohort Using Multistate Modeling

Clarke, Ann E. (författare)
University of Calgary
Hanly, John G. (författare)
Dalhousie University
Urowitz, Murray B. (författare)
University of Toronto
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St. Pierre, Yvan (författare)
McGill University Health Center
Gordon, Caroline (författare)
University of Birmingham
Bae, Sang Cheol (författare)
Hanyang University Hospital for Rheumatic Disease
Romero-Diaz, Juanita (författare)
Salvador Zubirán National Institute of Health Sciences and Nutrition
Sanchez-Guerrero, Jorge (författare)
University of Toronto
Bernatsky, Sasha (författare)
McGill University Health Center
Wallace, Daniel J. (författare)
University of California, Los Angeles
Isenberg, David A. (författare)
University College London
Rahman, Anisur (författare)
University College London
Merrill, Joan T. (författare)
Oklahoma Medical Research Foundation
Fortin, Paul R. (författare)
Centre hospitalier universitaire de Québec
Gladman, Dafna D. (författare)
University of Toronto
Bruce, Ian N. (författare)
Manchester Academic Health Science Centre
Petri, Michelle (författare)
Johns Hopkins University School of Medicine
Ginzler, Ellen M. (författare)
SUNY Downstate Health Sciences University
Dooley, Mary Anne (författare)
University of North Carolina
Ramsey-Goldman, Rosalind (författare)
Northwestern University
Manzi, Susan (författare)
Allegheny Health Network
Jönsen, Andreas (författare)
Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
Alarcón, Graciela S. (författare)
University of Alabama
Van Vollenhoven, Ronald F. (författare)
Academic Medical Center of University of Amsterdam (AMC)
Aranow, Cynthia (författare)
Feinstein Institute for Medical Research
Mackay, Meggan (författare)
Feinstein Institute for Medical Research
Ruiz-Irastorza, Guillermo (författare)
University of the Basque Country
Lim, S. Sam (författare)
Emory University
Inanc, Murat (författare)
Istanbul University
Kalunian, Kenneth C. (författare)
University of California, San Diego
Jacobsen, Soren (författare)
Copenhagen University Hospital
Peschken, Christine A. (författare)
University of Manitoba
Kamen, Diane L. (författare)
Medical University of South Carolina
Askanase, Anca (författare)
Indian Institute of Technology
Farewell, Vernon (författare)
University of Cambridge
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 (creator_code:org_t)
2023-02-23
2023
Engelska.
Ingår i: Arthritis Care and Research. - : Wiley. - 2151-464X .- 2151-4658. ; 75:9, s. 1859-1870
Relaterad länk:
http://dx.doi.org/10...
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https://lup.lub.lu.s...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Objective: To estimate direct and indirect costs associated with neuropsychiatric (NP) events in the Systemic Lupus International Collaborating Clinics inception cohort. Methods: NP events were documented annually using American College of Rheumatology definitions for NP events and attributed to systemic lupus erythematosus (SLE) or non-SLE causes. Patients were stratified into 1 of 3 NP states (no, resolved, or new/ongoing NP event). Change in NP status was characterized by interstate transition rates using multistate modeling. Annual direct costs and indirect costs were based on health care use and impaired productivity over the preceding year. Annual costs associated with NP states and NP events were calculated by averaging all observations in each state and adjusted through random-effects regressions. Five- and 10-year costs for NP states were predicted by multiplying adjusted annual costs per state by expected state duration, forecasted using multistate modeling. Results: A total of 1,697 patients (49% White race/ethnicity) were followed for a mean of 9.6 years. NP events (n = 1,971) occurred in 956 patients, 32% attributed to SLE. For SLE and non-SLE NP events, predicted annual, 5-, and 10-year direct costs and indirect costs were higher in new/ongoing versus no events. Direct costs were 1.5-fold higher and indirect costs 1.3-fold higher in new/ongoing versus no events. Indirect costs exceeded direct costs 3.0 to 5.2 fold. Among frequent SLE NP events, new/ongoing seizure disorder and cerebrovascular disease accounted for the largest increases in annual direct costs. For non-SLE NP events, new/ongoing polyneuropathy accounted for the largest increase in annual direct costs, and new/ongoing headache and mood disorder for the largest increases in indirect costs. Conclusion: Patients with new/ongoing SLE or non-SLE NP events incurred higher direct and indirect costs.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)

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