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Parental Prepuberty Overweight and Offspring Lung Function

Lonnebotn, M. (author)
Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway,Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, N-5020 Bergen, Norway.;Haukeland Hosp, Dept Occupat Med, N-5021 Bergen, Norway.
Calciano, L. (author)
Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy,Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, I-37134 Verona, Italy.
Johannessen, A. (author)
Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway,School of Public Health & Preventive Medicine, Monash University, VIC, Melbourne, Australia,Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, N-5020 Bergen, Norway.,Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic 3004, Australia.
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Jarvis, D. L. (author)
Faculty of Medicine, National Heart & Lung Institute, Imperial College, London, United Kingdom; MRC-PHE Centre for Environment and Health, Imperial College, London, United Kingdom,Imperial Coll, Fac Med, Natl Heart & Lung Inst, London SW7 2AZ, England.;Imperial Coll, MRC PHE Ctr Environm & Hlth, London W2 1PG, England.
Abramson, M. J. (author)
Benediktsdottir, B. (author)
Faculty of Medicine, University of Iceland, Reykjavik, Iceland,Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland.
Bråbäck, Lennart (author)
Umeå universitet,Avdelningen för hållbar hälsa,Umeå Univ, Dept Publ Hlth & Clin Med, Sect Sustainable Hlth, S-90187 Umeå, Sweden.
Franklin, Karl A. (author)
Umeå universitet,Kirurgi,Umeå Univ, Dept Surg & Perioperat Sci, Surg, S-90187 Umeåa, Sweden.
Godoy, R. (author)
Department of Pulmonary Medicine, University Hospital Complex of Albacete, University of Castilla La Mancha, Albacete, Spain,Univ Castilla La Mancha, Dept Pulm Med, Univ Hosp Complex Albacete, Albacete 02008, Spain.
Holm, Mathias, 1969 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Occupational and Environmental Medicine, Institute of Medicine, School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Acad, Sch Publ Hlth & Community Med, Occupat & Environm Med,Inst Med, S-40530 Gothenburg, Sweden.
Janson, Christer (author)
Uppsala universitet,Lung- allergi- och sömnforskning
Jogi, N. O. (author)
Department of Clinical Science, University of Bergen, Bergen, Norway,Univ Bergen, Dept Clin Sci, N-5021 Bergen, Norway.
Kirkeleit, J. (author)
Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway,Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, N-5020 Bergen, Norway.;Haukeland Hosp, Dept Occupat Med, N-5021 Bergen, Norway.
Malinovschi, Andrei, 1978- (author)
Uppsala universitet,Klinisk fysiologi
Pereira-Vega, A. (author)
Pneumology Service, Juan Ramón Jiménez University Hospital in Huelva, Huelva, Spain,Juan Ramon Jimenez Univ Hosp Huelva, Pneumol Serv, Huelva 21005, Spain.
Schlunssen, V. (author)
Department of Public Health, Environment, Work and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark; National Research Center for the Working Environment, Copenhagen, Denmark,Aarhus Univ, Danish Ramazzini Ctr, Dept Publ Hlth Environm Work & Hlth, DK-8000 Aarhus, Denmark.;Natl Res Ctr Working Environm, DK-2100 Copenhagen, Denmark.
Dharmage, S. C. (author)
Allergy and Lung Health Unit, School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia,Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway,Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic 3010, Australia.,Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, N-5020 Bergen, Norway.;Haukeland Hosp, Dept Occupat Med, N-5021 Bergen, Norway.
Accordini, S. (author)
Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy,Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, I-37134 Verona, Italy.
Real, F. G. (author)
Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway,Univ Bergen, Dept Clin Sci, N-5021 Bergen, Norway.;Haukeland Hosp, Dept Obstet & Gynecol, N-5053 Bergen, Norway.
Svanes, C. (author)
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Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, N-5020 Bergen, Norway;Haukeland Hosp, Dept Occupat Med, N-5021 Bergen, Norway. (creator_code:org_t)
2022-04-04
2022
English.
In: Nutrients. - : MDPI AG. - 2072-6643. ; 14:7
Related links:
https://doi.org/10.3...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • In a recent study we found that fathers' but not mothers' onset of overweight in puberty was associated with asthma in adult offspring. The potential impact on offspring's adult lung function, a key marker of general and respiratory health, has not been studied. We investigated the potential causal effects of parents' overweight on adult offspring's lung function within the paternal and maternal lines. We included 929 offspring (aged 18-54, 54% daughters) of 308 fathers and 388 mothers (aged 40-66). Counterfactual-based multi-group mediation analyses by offspring's sex (potential moderator) were used, with offspring's prepubertal overweight and/or adult height as potential mediators. Unknown confounding was addressed by simulation analyses. Fathers' overweight before puberty had a negative indirect effect, mediated through sons' height, on sons' forced expiratory volume in one second (FEV1) (beta (95% CI): -144 (-272, -23) mL) and forced vital capacity (FVC) (beta (95% CI): -210 (-380, -34) mL), and a negative direct effect on sons' FVC (beta (95% CI): -262 (-501, -9) mL); statistically significant effects on FEV1/FVC were not observed. Mothers' overweight before puberty had neither direct nor indirect effects on offspring's lung function. Fathers' overweight starting before puberty appears to cause lower FEV1 and FVC in their future sons. The effects were partly mediated through sons' adult height but not through sons' prepubertal overweight.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

Keyword

lung function
overweight
nutrition
prepuberty
father
paternal
male
men
causal inference
intergenerational
counterfactual-based
mediation analysis
ECRHS
RHINE
RHINESSA
high-fat diet
paternal obesity
epigenetic inheritance
gene-expression
body-fat
health
growth
origins
puberty
girls
Nutrition & Dietetics
causal inference

Publication and Content Type

ref (subject category)
art (subject category)

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