Search: WFRF:(Malone Kathleen E)
> (2010) >
Oral contraceptives...
Oral contraceptives and postmenopausal hormones and risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers and noncarriers: the WECARE Study
-
Figueiredo, Jane C. (author)
-
Haile, Robert W. (author)
-
Bernstein, Leslie (author)
-
show more...
-
Malone, Kathleen E. (author)
-
Largent, Joan (author)
-
Langholz, Bryan (author)
-
Lynch, Charles F. (author)
-
Bertelsen, Lisbeth (author)
-
Capanu, Marinela (author)
-
Concannon, Patrick (author)
-
- Borg, Åke (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
Borresen-Dale, Anne-Lise (author)
-
Diep, Anh (author)
-
Teraoka, Sharon (author)
-
- Törngren, Therese (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
Xue, Shanyan (author)
-
Bernstein, Jonine L. (author)
-
show less...
-
(creator_code:org_t)
- 2009-07-14
- 2010
- English.
-
In: Breast Cancer Research and Treatment. - : Springer Science and Business Media LLC. - 1573-7217 .- 0167-6806. ; 120:1, s. 175-183
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://europepmc.or...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The potential effects of oral contraceptive (OC) and postmenopausal hormone (PMH) use are not well understood among BRCA1 or BRCA2 (BRCA1/2) deleterious mutation carriers with a history of breast cancer. We investigated the association between OC and PMH use and risk of contralateral breast cancer (CBC) in the WECARE (Women's Environment, Cancer, and Radiation Epidemiology) Study. The WECARE Study is a population-based case-control study of 705 women with asynchronous CBC and 1,398 women with unilateral breast cancer, including 181 BRCA1/2 mutation carriers. Risk-factor information was assessed by telephone interview. Mutation status was measured using denaturing high-performance liquid chromatography followed by direct sequencing in all participants. Outcomes, treatment, and tumor characteristics were abstracted from medical records. Ever use of OCs was not associated with risk among noncarriers (RR = 0.87; 95% CI = 0.66-1.15) or BRCA2 carriers (RR = 0.82; 95% CI = 0.21-3.13). BRCA1 carriers who used OCs had a nonsignificant greater risk than nonusers (RR = 2.38; 95% CI = 0.72-7.83). Total duration of OC use and at least 5 years of use before age 30 were associated with a nonsignificant increased risk among mutation carriers but not among noncarriers. Few women had ever used PMH and we found no significant associations between lifetime use and CBC risk among carriers and noncarriers. In conclusion, the association between OC/PMH use and risk of CBC does not differ significantly between carriers and noncarriers; however, because carriers have a higher baseline risk of second primaries, even a potential small increase in risk as a result of OC use may be clinically relevant.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- BRCA2
- BRCA1
- Postmenopausal hormones
- contraceptives
- Oral
- Contralateral
- Breast cancer
- Asynchronous bilateral
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Figueiredo, Jane ...
-
Haile, Robert W.
-
Bernstein, Lesli ...
-
Malone, Kathleen ...
-
Largent, Joan
-
Langholz, Bryan
-
show more...
-
Lynch, Charles F ...
-
Bertelsen, Lisbe ...
-
Capanu, Marinela
-
Concannon, Patri ...
-
Borg, Åke
-
Borresen-Dale, A ...
-
Diep, Anh
-
Teraoka, Sharon
-
Törngren, Theres ...
-
Xue, Shanyan
-
Bernstein, Jonin ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Breast Cancer Re ...
- By the university
-
Lund University