Genetic association study of childhood aggression across raters, instruments, and age

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Genetic association study of childhood aggression across raters, instruments, and age

Ip, H. F. (author): Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

van der Laan, C. M. (author)

Krapohl, E. M. L. (author)

Brikell, I. (author): Karolinska Institutet

Sanchez-Mora, C. (author)

Nolte, I. M. (author)

St Pourcain, B. (author)

Bolhuis, K. (author)

Palviainen, T. (author)

Zafarmand, H. (author)

Colodro-Conde, L. (author)

Gordon, S. (author)

Zayats, T. (author)

Aliev, F. (author)

Jiang, C. (author)

Wang, C. R. A. (author)

Saunders, G. (author)

Karhunen, V. (author)

Hammerschlag, A. R. (author)

Adkins, D. E. (author)

Border, R. (author)

Peterson, R. E. (author)

Prinz, J. A. (author)

Thiering, E. (author)

Seppala, I. (author)

Vilor-Tejedor, N. (author)

Ahluwalia, T. S. (author)

Day, F. R. (author)

Hottenga, J. J. (author)

Allegrini, A. G. (author)

Rimfeld, K. (author)

Chen, Q. (author)

Lu, Y. (author): Karolinska Institutet

Martin, J. (author)

Artigas, M. S. (author)

Rovira, P. (author)

Bosch, R. (author)

Espanol, G. (author)

Quiroga, J. A. R. (author)

Neumann, A. (author)

Ensink, J. (author)

Grasby, K. (author)

Morosoli, J. J. (author)

Tong, X. R. (author)

Marrington, S. (author)

Middeldorp, C. (author)

Scott, J. G. (author)

Vinkhuyzen, A. (author)

Shabalin, A. A. (author)

Corley, R. (author)

Evans, L. M. (author)

Sugden, K. (author)

Alemany, S. (author)

Sass, L. (author)

Vinding, R. (author)

Ruth, K. (author)

Tyrrell, J. (author)

Davies, G. E. (author)

Ehli, E. A. (author)

Hagenbeek, F. A. (author)

De Zeeuw, E. (author)

Van Beijsterveldt, Tcem (author)

Larsson, Henrik, 1975- (author): Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Snieder, H. (author)

Verhulst, F. C. (author)

Amin, N. (author)

Whipp, A. M. (author)

Korhonen, T. (author)

Vuoksimaa, E. (author)

Rose, R. J. (author)

Uitterlinden, A. G. (author)

Heath, A. C. (author)

Madden, P. (author)

Haavik, J. (author)

Harris, J. R. (author)

Helgeland, O. (author)

Johansson, S. (author)

Knudsen, G. P. S. (author)

Njolstad, P. R. (author)

Lu, Q. (author)

Rodriguez, A. (author)

Henders, A. K. (author)

Mamun, A. (author)

Najman, J. M. (author)

Brown, S. (author)

Hopfer, C. (author)

Krauter, K. (author)

Reynolds, C. (author)

Smolen, A. (author)

Stallings, M. (author)

Wadsworth, S. (author)

Wall, T. L. (author)

Silberg, J. L. (author)

Miller, A. (author)

Keltikangas-Jarvinen, L. (author)

Hakulinen, C. (author)

Pulkki-Raback, L. (author): Karolinska Institutet

Havdahl, A. (author)

Magnus, P. (author)

Raitakari, O. T. (author)

Perry, J. R. B. (author)

Llop, S. (author)

Lopez-Espinosa, M. J. (author)

Bonnelykke, K. (author)

Bisgaard, H. (author)

Sunyer, J. (author)

Lehtimaki, T. (author)

Arseneault, L. (author)

Standl, M. (author)

Heinrich, J. (author)

Boden, J. (author)

Pearson, J. (author)

Horwood, L. J. (author)

Kennedy, M. (author)

Poulton, R. (author)

Eaves, L. J. (author)

Maes, H. H. (author)

Hewitt, J. (author)

Copeland, W. E. (author)

Costello, E. J. (author)

Williams, G. M. (author)

Wray, N. (author)

Jarvelin, M. R. (author)

McGue, M. (author)

Iacono, W. (author)

Caspi, A. (author)

Moffitt, T. E. (author)

Whitehouse, A. (author)

Pennell, C. E. (author)

Klump, K. L. (author)

Burt, S. A. (author)

Dick, D. M. (author)

Reichborn-Kjennerud, T. (author)

Martin, N. G. (author)

Medland, S. E. (author)

Vrijkotte, T. (author)

Kaprio, J. (author)

Tiemeier, H. (author)

Smith, G. D. (author)

Hartman, C. A. (author)

Oldehinkel, A. J. (author)

Casas, M. (author)

Ribases, M. (author)

Lichtenstein, P. (author)

Lundström, Sebastian (author): Gothenburg University,Göteborgs universitet,Gillbergcentrum,Centrum för etik, juridik och mental hälsa,Gillberg Neuropsychiatry Centre,Centre for Ethics, Law, and Mental Health

Plomin, R. (author)

Bartels, M. (author)

Nivard, M. G. (author)

Boomsma, D. I. (author): Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands

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(creator_code:org_t)

2021-07-30
2021
English.
In: Translational Psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 11:1

Related links:: https://www.nature.c...; show more...; https://doi.org/10.1...; https://gup.ub.gu.se...; https://doi.org/10.1...; https://urn.kb.se/re...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association metaanalysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assessors were included. We analyzed phenotype assessments for a total of 328 935 observations from 87 485 children aged between 1.5 and 18 years, while accounting for sample overlap. We also meta-analyzed within subsets of the data, i.e., within rater, instrument and age. SNP-heritability for the overall meta-analysis (AGGoverall) was 3.31% (SE= 0.0038). We found no genome-wide significant SNPs for AGG(overall). The gene-based analysis returned three significant genes: ST3GAL3 (P= 1.6E-06), PCDH7 (P= 2.0E-06), and IPO13 (P= 2.5E-06). All three genes have previously been associated with educational traits. Polygenic scores based on our GWAMA significantly predicted aggression in a holdout sample of children (variance explained = 0.44%) and in retrospectively assessed childhood aggression (variance explained = 0.20%). Genetic correlations (rg) among rater-specific assessment of AGG ranged from r(g)= 0.46 between self- and teacher-assessment to r(g)d= 0.81 between mother- and teacher-assessment. We obtained moderate-to-strong rgs with selected phenotypes from multiple domains, but hardly with any of the classical biomarkers thought to be associated with AGG. Significant genetic correlations were observed with most psychiatric and psychological traits (range r(g): 0.19-1.00), except for obsessive-compulsive disorder. Aggression had a negative genetic correlation (r(g)=-0.5) with cognitive traits and age at first birth. Aggression was strongly genetically correlated with smoking phenotypes (range |r(g)| : 0.46-0.60). The genetic correlations between aggression and psychiatric disorders were weaker for teacher-reported AGG than for mother- and self-reported AGG. The current GWAMA of childhood aggression provides a powerful tool to interrogate the rater-specific genetic etiology of AGG.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)

Keyword

genome-wide association
trajectories
heritability
adolescence
disorder
behavior
origins
Psychiatry

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor: Ip, H. F.; van der Laan, C. ...; Krapohl, E. M. L ...; Brikell, I.; Sanchez-Mora, C.; Nolte, I. M.; show more...; St Pourcain, B.; Bolhuis, K.; Palviainen, T.; Zafarmand, H.; Colodro-Conde, L ...; Gordon, S.; Zayats, T.; Aliev, F.; Jiang, C.; Wang, C. R. A.; Saunders, G.; Karhunen, V.; Hammerschlag, A. ...; Adkins, D. E.; Border, R.; Peterson, R. E.; Prinz, J. A.; Thiering, E.; Seppala, I.; Vilor-Tejedor, N ...; Ahluwalia, T. S.; Day, F. R.; Hottenga, J. J.; Allegrini, A. G.; Rimfeld, K.; Chen, Q.; Lu, Y.; Martin, J.; Artigas, M. S.; Rovira, P.; Bosch, R.; Espanol, G.; Quiroga, J. A. R ...; Neumann, A.; Ensink, J.; Grasby, K.; Morosoli, J. J.; Tong, X. R.; Marrington, S.; Middeldorp, C.; Scott, J. G.; Vinkhuyzen, A.; Shabalin, A. A.; Corley, R.; Evans, L. M.; Sugden, K.; Alemany, S.; Sass, L.; Vinding, R.; Ruth, K.; Tyrrell, J.; Davies, G. E.; Ehli, E. A.; Hagenbeek, F. A.; De Zeeuw, E.; Van Beijsterveld ...; Larsson, Henrik, ...; Snieder, H.; Verhulst, F. C.; Amin, N.; Whipp, A. M.; Korhonen, T.; Vuoksimaa, E.; Rose, R. J.; Uitterlinden, A. ...; Heath, A. C.; Madden, P.; Haavik, J.; Harris, J. R.; Helgeland, O.; Johansson, S.; Knudsen, G. P. S ...; Njolstad, P. R.; Lu, Q.; Rodriguez, A.; Henders, A. K.; Mamun, A.; Najman, J. M.; Brown, S.; Hopfer, C.; Krauter, K.; Reynolds, C.; Smolen, A.; Stallings, M.; Wadsworth, S.; Wall, T. L.; Silberg, J. L.; Miller, A.; Keltikangas-Jarv ...; Hakulinen, C.; Pulkki-Raback, L ...; Havdahl, A.; Magnus, P.; Raitakari, O. T.; Perry, J. R. B.; Llop, S.; Lopez-Espinosa, ...; Bonnelykke, K.; Bisgaard, H.; Sunyer, J.; Lehtimaki, T.; Arseneault, L.; Standl, M.; Heinrich, J.; Boden, J.; Pearson, J.; Horwood, L. J.; Kennedy, M.; Poulton, R.; Eaves, L. J.; Maes, H. H.; Hewitt, J.; Copeland, W. E.; Costello, E. J.; Williams, G. M.; Wray, N.; Jarvelin, M. R.; McGue, M.; Iacono, W.; Caspi, A.; Moffitt, T. E.; Whitehouse, A.; Pennell, C. E.; Klump, K. L.; Burt, S. A.; Dick, D. M.; Reichborn-Kjenne ...; Martin, N. G.; Medland, S. E.; Vrijkotte, T.; Kaprio, J.; Tiemeier, H.; Smith, G. D.; Hartman, C. A.; Oldehinkel, A. J ...; Casas, M.; Ribases, M.; Lichtenstein, P.; Lundström, Sebas ...; Plomin, R.; Bartels, M.; Nivard, M. G.; Boomsma, D. I.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

Articles in the publication: Translational Ps ...

By the university: University of Gothenburg; Örebro University; Karolinska Institutet

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