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Sökning: onr:"swepub:oai:DiVA.org:oru-74047" > The frequency and i...

The frequency and influence of dementia risk factors in prodromal Alzheimer's disease

Bos, Isabelle (författare)
Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, Netherlands
Vos, Stephanie J. (författare)
Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, Netherlands
Frölich, Lutz (författare)
Department of Geriatric Psychiatry, Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany
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Kornhuber, Johannes (författare)
Department of Psychiatry and Psychotherapy, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany
Wiltfang, Jens (författare)
Department of Psychiatry and Psychotherapy, University Medical Center (UMC), Georg-August-University, Göttingen, Germany
Maier, Wolfgang (författare)
Department of Psychiatry and Psychotherapy, University of Bonn, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
Peters, Oliver (författare)
Department of Psychiatry and Psychotherapy, Charité Berlin, Berlin, Germany,Charité - University Medicine Berlin
Rüther, Eckhart (författare)
Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Germany
Engelborghs, Sebastiaan (författare)
Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium; Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium
Niemantsverdriet, Ellis (författare)
Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium
De Roeck, Ellen Elisa (författare)
Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium; Department of Clinical and Lifespan Psychology, Vrije Universiteit Brussel, Brussels, Belgium,Vrije Universiteit Brussel (VUB)
Tsolaki, Magda (författare)
3rd Department of Neurology, Aristotle University of Thessaloniki, Memory and Dementia Center, “G Papanicolau” General Hospital, Thessaloniki, Greece
Freund-Levi, Yvonne, 1956- (författare)
Karolinska Institute,Karolinska University Hospital
Johannsen, Peter (författare)
Danish Dementia Research Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Vandenberghe, Rik (författare)
Department of Neurology, University of Hospital Leuven, Leuven, Belgium; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Belgium,Catholic University of Leuven
Lleó, Alberto (författare)
Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Alcolea, Daniel (författare)
Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Frisoni, Giovanni B. (författare)
Geneva Neuroscience Center, University Hospital and University of Geneva, Geneva, Switzerland; IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Galluzzi, Samantha (författare)
IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy,Centro San Giovanni di Dio Fatebenefratelli
Nobili, Flavio (författare)
Clinical Neurology, Department of Neurosciences (DINOGMI), University of Genoa and IRCCS AOU San Martino-IST, Genoa, Italy,Ospedale Policlinico San Martino
Morbelli, Silvia (författare)
Nuclear Medicine, Department of Health Science (DISSAL), University of Genoa IRCCS AOU San Martino-IST, Genoa, Italy,Ospedale Policlinico San Martino
Drzezga, Alexander (författare)
Department of Nuclear Medicine, University of Cologne, Cologne, Germany
Didic, Mira (författare)
AP-HM Hôpitaux de la Timone, Service de Neurologie et Neuropsychologie, Marseille, France; Aix-Marseille Université, INSERM, Institut de Neurosciences des Systèmes, Marseille, France,La Timone University Hospital
van Berckel, Bart N. (författare)
Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands,Amsterdam UMC - Vrije Universiteit Amsterdam
Salmon, Eric (författare)
Department of Neurology and Memory Clinic, CHU Liège, Liège, Belgium; GIGA-CRC in vivo Imaging, University of Liège, Liège, Belgium,University of Liège Hospital
Bastin, Christine (författare)
GIGA-CRC in vivo Imaging, University of Liège, Liège, Belgium
Dauby, Solene (författare)
Department of Neurology and Memory Clinic, CHU Liège, Liège, Belgium,University of Liège Hospital
Santana, Isabel (författare)
Department of Neurology and Memory Clinic, CHU Liège, Liège, Belgium,University of Liège Hospital
Baldeiras, Inês (författare)
Center for Neuroscience and Cell Biology, Faculty of Medicine, Department of Neurology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal,University Hospital of Coimbra
de Mendonça, Alexandre (författare)
Institute of Molecular Medicine and Faculty of Medicine, University of Lisbon, Portugal
Silva, Dina (författare)
Institute of Molecular Medicine and Faculty of Medicine, University of Lisbon, Portugal
Wallin, Anders, 1950 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Nordlund, Arto, 1962 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Coloma, Preciosa M. (författare)
Real World Data Science (RWD-S) Neuroscience and Established Products, F. Hoffmann-La Roche Ltd. Pharmaceuticals Division, Basel, Switzerland
Wientzek, Angelika (författare)
PDB RWD (Real World Data) Team, Roche Products Limited, Welwyn Garden City, UK; Epidemiologische Beratung und Literatur-Recherche “conepi”, Herrsching, Germany
Alexander, Myriam (författare)
PDB RWD (Real World Data) Team, Roche Products Limited, Welwyn Garden City, UK
Novak, Gerald P. (författare)
Janssen Pharmaceutical Research and Development, Titusville, NJ, USA
Gordon, Mark Forrest (författare)
Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT, USA
Wallin, Åsa K. (författare)
Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
Hampel, Harald (författare)
Sorbonne Universités, Université Pierre et Marie Curie, Paris 06, AXA Research Fund & UPMC Chair, Institut de la Mémoire et de la Maladie d’Alzheimer (IM2A), Paris, France; Institut du Cerveau et de la Moelle épinière (ICM), Département de Neurologie, Hôpital de la Pitié-Salpétrière, Paris, France
Soininen, Hilkka (författare)
Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland; Neurocenter, Neurology, Kuopio University Hospital, Kuopio, Finland
Herukka, Sanna-Kaisa (författare)
Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland; Neurocenter, Neurology, Kuopio University Hospital, Kuopio, Finland
Scheltens, Philip (författare)
Alzheimer Center & Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, Netherlands,Amsterdam UMC - Vrije Universiteit Amsterdam
Verhey, Frans R. (författare)
Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, Netherlands
Visser, Pieter Jelle (författare)
Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, Netherlands; Alzheimer Center & Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, Netherlands,Amsterdam UMC - Vrije Universiteit Amsterdam
Alzheimer's Disease Neuroimaging Initiative, the (bidragsgivare)
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 (creator_code:org_t)
Elsevier, 2017
2017
Engelska.
Ingår i: Neurobiology of Aging. - : Elsevier. - 0197-4580 .- 1558-1497. ; 56, s. 33-40
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Cox-regression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hypercholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with mild cognitive impairment. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e., preclinical) of AD.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Geriatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Geriatrics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Nyckelord

Alzheimer's disease
Biomarkers
IWG-2 criteria
NIA-AA criteria
Prognosis
Risk factors
Alzheimer's disease
Biomarkers
IWG-2 criteria
NIA-AA criteria
Prognosis
Risk factors

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