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Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
- de Jong, S (author)
-
- Diniz, MJA (author)
- Karolinska Institutet
- Saloma, A (author)
- show more...
- Gadelha, A (author)
- Ota, VK (author)
- Noto, C (author)
- Curtis, C (author)
- Newhouse, SJ (author)
- Patel, H (author)
- Hall, LS (author)
- O'Reilly, PF (author)
- Belangero, SI (author)
- Breen, G (author)
- Wray, NR (author)
- Ripke, S (author)
- Trzaskowski, M (author)
- Byrne, EM (author)
- Adams, MJ (author)
- Agerbo, E (author)
- Air, TM (author)
- Andlauer, TFM (author)
- Bacanu, SA (author)
- Baekvad-Hansen, M (author)
- Beekman, ATF (author)
- Bigdeli, TB (author)
- Binder, EB (author)
- Blackwood, DHR (author)
- Buttenschon, HN (author)
- Bybjerg-Grauholm, J (author)
- Cai, N (author)
- Castelao, E (author)
- Christensen, JH (author)
- Clarke, TK (author)
- Coleman, JRI (author)
- Colodro-Conde, L (author)
- Couvy-Duchesne, B (author)
- Craddock, N (author)
- Crawford, GE (author)
- Davies, G (author)
- Deary, IJ (author)
- Degenhardt, F (author)
- Derks, EM (author)
- Direk, N (author)
- Dolan, CV (author)
- Dunn, EC (author)
- Eley, TC (author)
- Escott-Price, V (author)
- Kiadeh, FFH (author)
- Finucane, HK (author)
- Forstner, AJ (author)
- Frank, J (author)
- Gaspar, HA (author)
- Gill, M (author)
- Goes, FS (author)
- Gordon, SD (author)
- Grove, J (author)
- Hansen, CS (author)
- Hansen, TF (author)
- Herms, S (author)
- Hickie, IB (author)
- Hoffmann, P (author)
- Homuth, G (author)
- Horn, C (author)
- Hottenga, JJ (author)
- Hougaard, DM (author)
- Ising, M (author)
- Jansen, R (author)
- Jones, I (author)
- Jones, LA (author)
- Jorgenson, E (author)
- Knowles, JA (author)
- Kohane, IS (author)
- Kraft, J (author)
- Kretzschmar, WW (author)
- Krogh, J (author)
- Kutalik, Z (author)
- Li, YH (author)
- Lind, PA (author)
- MacIntyre, DJ (author)
- MacKinnon, DF (author)
- Maier, RM (author)
- Maier, W (author)
- Marchini, J (author)
- Mbarek, H (author)
- McGrath, P (author)
- McGuffin, P (author)
- Medland, SE (author)
- Mehta, D (author)
- Middeldorp, CM (author)
- Mihailov, E (author)
- Milaneschi, Y (author)
- Milani, L (author)
- Mondimore, FM (author)
- Montgomery, GW (author)
- Mostafavi, S (author)
- Mullins, N (author)
- Nauck, M (author)
- Ng, B (author)
- Nivard, MG (author)
- Nyholt, DR (author)
- Oskarsson, H (author)
- Owen, MJ (author)
- Painter, JN (author)
- Pedersen, CB (author)
- Pedersen, MG (author)
- Peyrot, WJ (author)
- Pistis, G (author)
- Posthuma, D (author)
- Quiroz, JA (author)
- Qvist, P (author)
- Rice, JP (author)
- Riley, BP (author)
- Rivera, M (author)
- Mirza, SS (author)
- Schoevers, R (author)
- Schulte, EC (author)
- Shen, L (author)
- Shyn, SI (author)
- Sinnamon, GCB (author)
- Smit, JH (author)
- Smith, DJ (author)
- Stefansson, H (author)
- Steinberg, S (author)
- Streit, F (author)
- Strohmaier, J (author)
- Tansey, KE (author)
- Teismann, H (author)
- Teumer, A (author)
- Thompson, W (author)
- Thomson, PA (author)
- Thorgeirsson, TE (author)
- Traylor, M (author)
- Treutlein, J (author)
- Trubetskoy, V (author)
- Uitterlinden, AG (author)
- Umbricht, D (author)
- Van der Auwera, S (author)
- van Hemert, AM (author)
- Visscher, PM (author)
- Wang, YP (author)
- Webb, BT (author)
- Weinsheimer, SM (author)
- Wellmann, J (author)
- Willemsen, G (author)
- Witt, SH (author)
- Wu, Y (author)
- Xi, HLS (author)
- Yang, J (author)
- Zhang, FT (author)
- Arolt, V (author)
- Baune, BT (author)
- Berger, K (author)
- Boomsma, DI (author)
- Cichon, S (author)
- Dannlowski, U (author)
- de Geus, EJC (author)
- DePaulo, JR (author)
- Domenici, E (author)
- Domschke, K (author)
- Esko, T (author)
- Grabe, HJ (author)
- Hamilton, SP (author)
- Hayward, C (author)
- Heath, AC (author)
- Kendler, KS (author)
- Kloiber, S (author)
- Lewis, G (author)
- Li, QQS (author)
- Lucae, S (author)
- Madden, PAF (author)
- Martin, NG (author)
- McIntosh, AM (author)
- Metspalu, A (author)
- Mors, O (author)
- Mortensen, PB (author)
- Muller-Myhsok, B (author)
- Nordentoft, M (author)
- Nothen, MM (author)
- O'Donovan, MC (author)
- Paciga, SA (author)
- Penninx, BWJH (author)
- Perlis, RH (author)
- Porteous, DJ (author)
- Potash, JB (author)
- Preisig, M (author)
- Rietschel, M (author)
- Schaefer, C (author)
- Schulze, TG (author)
- Smoller, JW (author)
- Stefansson, K (author)
- Tiemeier, H (author)
- Uher, R (author)
- Volzke, H (author)
- Weissman, MM (author)
- Werge, T (author)
- Lewis, CM (author)
- Borglum, AD (author)
- Meier, S (author)
- Strauss, J (author)
- Xu, W (author)
- Vincent, JB (author)
- Matthews, K (author)
- Ferreira, M (author)
- O'Dushlaine, C (author)
- Purcell, S (author)
- Raychaudhuri, S (author)
- Ruderfer, DM (author)
- Sklar, P (author)
- Scott, LJ (author)
- Flickinger, M (author)
- Burmeister, M (author)
- Li, J (author)
- Guan, WH (author)
- Absher, D (author)
- Thompson, RC (author)
- Meng, FG (author)
- Schatzberg, AF (author)
- Bunney, WE (author)
- Barchas, JD (author)
- Watson, SJ (author)
- Myers, RM (author)
- Akil, H (author)
- Boehnke, M (author)
- Chambert, K (author)
- Moran, J (author)
- Scolnick, E (author)
- Djurovic, S (author)
- Melle, I (author)
- Morken, G (author)
- Anjorin, A (author)
- Kandaswamy, R (author)
- Lawrence, J (author)
- McLean, AW (author)
- Pickard, BS (author)
- Nimgaonkar, V (author)
- Osby, U (author)
- Stahl, E (author)
- Dobbyn, A (author)
- Jamain, S (author)
- Etain, B (author)
- Bellivier, F (author)
- Leber, M (author)
- Maaser, A (author)
- Fischer, SB (author)
- Reinbold, CS (author)
- Kittel-Schneider, S (author)
- Fullerton, JM (author)
- Oruc, L (author)
- Para, JG (author)
- Mayoral, F (author)
- Rivas, F (author)
- Czerski, PM (author)
- Kammerer-Ciernioch, J (author)
- Vedder, H (author)
- Borrmann-Hassenbach, M (author)
- Pfennig, A (author)
- Brennan, P (author)
- McKay, JD (author)
- Kogevinas, M (author)
- Schwarz, M (author)
- Schofield, PR (author)
- Muhleisen, TW (author)
- Schumacher, J (author)
- Bauer, M (author)
- Wright, A (author)
- Mitchell, PB (author)
- Hautzinger, M (author)
- Kelsoe, JR (author)
- Greenwood, TA (author)
- Nievergelt, CM (author)
- Shilling, PD (author)
- Smith, EN (author)
- Bloss, CS (author)
- Edenberg, HJ (author)
- Koller, DL (author)
- Gershon, ES (author)
- Liu, CY (author)
- Badner, JA (author)
- Scheftner, WA (author)
- Lawson, WB (author)
- Nwulia, EA (author)
- Hipolito, M (author)
- Coryell, W (author)
- Rice, J (author)
- Byerley, W (author)
- McMahon, FJ (author)
- Lohoff, FW (author)
- Zandi, PP (author)
- Mahon, PB (author)
- McInnis, MG (author)
- Zollner, S (author)
- Zhang, P (author)
- Szelinger, S (author)
- St Clair, D (author)
- Caesar, S (author)
- Gordon-Smith, K (author)
- Fraser, C (author)
- Green, EK (author)
- Grozeva, D (author)
- Hamshere, ML (author)
- Kirov, G (author)
- Nikolov, I (author)
- Collier, DA (author)
- Elkin, A (author)
- Williamson, R (author)
- Young, AH (author)
- Ferrier, IN (author)
- Milanova, V (author)
- Alda, M (author)
- Cervantes, P (author)
- Cruceanu, C (author)
- Rouleau, GA (author)
- Turecki, G (author)
- Paciga, S (author)
- Winslow, AR (author)
- Grigoroiu-Serbanescu, M (author)
- Ophoff, R (author)
- Adolfsson, R (author)
- Adolfsson, AN (author)
- Del-Favero, J (author)
- Pato, C (author)
- Biernacka, JM (author)
- Frye, MA (author)
- Morris, D (author)
- Schork, NJ (author)
- Reif, A (author)
- Lissowska, J (author)
- Hauser, J (author)
- Szeszenia-Dabrowska, N (author)
- McGhee, K (author)
- Quinn, E (author)
- Moskvina, V (author)
- Holmans, PA (author)
- Farmer, A (author)
- Kennedy, JL (author)
- Andreassen, OA (author)
- Mattingsdal, M (author)
- Bass, NJ (author)
- Gurling, H (author)
- McQuillin, A (author)
- Breuer, R (author)
- Hultman, C (author)
- Huckins, LM (author)
- Leboyer, M (author)
- Lathrop, M (author)
- Nurnberger, J (author)
- Steffens, M (author)
- Foroud, TM (author)
- Berrettini, WH (author)
- Craig, DW (author)
- Shi, JX (author)
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- (creator_code:org_t)
- 2018-10-08
- 2018
- English.
- In: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 1, s. 163-
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
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- ref (subject category)
- art (subject category)
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- de Jong, S
- Diniz, MJA
- Saloma, A
- Gadelha, A
- Landén, Mikael, ...
- Ota, VK
- show more...
- Noto, C
- Curtis, C
- Newhouse, SJ
- Patel, H
- Hall, LS
- O'Reilly, PF
- Belangero, SI
- Adolfsson, Rolf
- Breen, G
- Wray, NR
- Ripke, S
- Mattheisen, M
- Trzaskowski, M
- Byrne, EM
- Abdellaoui, A
- Adams, MJ
- Agerbo, E
- Air, TM
- Andlauer, TFM
- Bacanu, SA
- Baekvad-Hansen, ...
- Beekman, ATF
- Bigdeli, TB
- Binder, EB
- Blackwood, DHR
- Bryois, J
- Buttenschon, HN
- Bybjerg-Grauholm ...
- Cai, N
- Castelao, E
- Christensen, JH
- Clarke, TK
- Coleman, JRI
- Colodro-Conde, L
- Couvy-Duchesne, ...
- Craddock, N
- Crawford, GE
- Davies, G
- Deary, IJ
- Degenhardt, F
- Derks, EM
- Direk, N
- Dolan, CV
- Dunn, EC
- Eley, TC
- Escott-Price, V
- Kiadeh, FFH
- Finucane, HK
- Forstner, AJ
- Frank, J
- Gaspar, HA
- Gill, M
- Goes, FS
- Gordon, SD
- Grove, J
- Hansen, CS
- Hansen, TF
- Herms, S
- Hickie, IB
- Hoffmann, P
- Homuth, G
- Horn, C
- Hottenga, JJ
- Hougaard, DM
- Ising, M
- Jansen, R
- Jones, I
- Jones, LA
- Jorgenson, E
- Knowles, JA
- Kohane, IS
- Kraft, J
- Kretzschmar, WW
- Krogh, J
- Kutalik, Z
- Li, YH
- Lind, PA
- MacIntyre, DJ
- MacKinnon, DF
- Maier, RM
- Maier, W
- Marchini, J
- Mbarek, H
- McGrath, P
- McGuffin, P
- Medland, SE
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- Milaneschi, Y
- Milani, L
- Mondimore, FM
- Montgomery, GW
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- Mullins, N
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- Ng, B
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- Oskarsson, H
- Owen, MJ
- Painter, JN
- Pedersen, CB
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- Peyrot, WJ
- Pistis, G
- Posthuma, D
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- Rice, JP
- Riley, BP
- Rivera, M
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- Smith, DJ
- Stefansson, H
- Steinberg, S
- Streit, F
- Strohmaier, J
- Tansey, KE
- Teismann, H
- Teumer, A
- Thompson, W
- Thomson, PA
- Thorgeirsson, TE
- Traylor, M
- Treutlein, J
- Trubetskoy, V
- Uitterlinden, AG
- Umbricht, D
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- van Hemert, AM
- Viktorin, A
- Visscher, PM
- Wang, YP
- Webb, BT
- Weinsheimer, SM
- Wellmann, J
- Willemsen, G
- Witt, SH
- Wu, Y
- Xi, HLS
- Yang, J
- Zhang, FT
- Arolt, V
- Baune, BT
- Berger, K
- Boomsma, DI
- Cichon, S
- Dannlowski, U
- de Geus, EJC
- DePaulo, JR
- Domenici, E
- Domschke, K
- Esko, T
- Grabe, HJ
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- Heath, AC
- Kendler, KS
- Kloiber, S
- Lewis, G
- Li, QQS
- Lucae, S
- Madden, PAF
- Magnusson, PK
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- Mortensen, PB
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- Nordentoft, M
- Nothen, MM
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- Paciga, SA
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- Porteous, DJ
- Potash, JB
- Preisig, M
- Rietschel, M
- Schaefer, C
- Schulze, TG
- Smoller, JW
- Stefansson, K
- Tiemeier, H
- Uher, R
- Volzke, H
- Weissman, MM
- Werge, T
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- Sullivan, PF
- Meier, S
- Strauss, J
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- Ferreira, M
- O'Dushlaine, C
- Purcell, S
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- Ruderfer, DM
- Sklar, P
- Scott, LJ
- Flickinger, M
- Burmeister, M
- Li, J
- Guan, WH
- Absher, D
- Thompson, RC
- Meng, FG
- Schatzberg, AF
- Bunney, WE
- Barchas, JD
- Watson, SJ
- Myers, RM
- Akil, H
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- Chambert, K
- Moran, J
- Scolnick, E
- Djurovic, S
- Melle, I
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- Nordin Adolfsson ...
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- McLean, AW
- Pickard, BS
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- Brennan, P
- McKay, JD
- Kogevinas, M
- Schwarz, M
- Schofield, PR
- Muhleisen, TW
- Schumacher, J
- Bauer, M
- Wright, A
- Mitchell, PB
- Hautzinger, M
- Kelsoe, JR
- Greenwood, TA
- Nievergelt, CM
- Shilling, PD
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- Bloss, CS
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- Scheftner, WA
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- Hamshere, ML
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- Williamson, R
- Young, AH
- Ferrier, IN
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- Schork, NJ
- Reif, A
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- Quinn, E
- Moskvina, V
- Holmans, PA
- Farmer, A
- Kennedy, JL
- Andreassen, OA
- Mattingsdal, M
- Bass, NJ
- Gurling, H
- McQuillin, A
- Breuer, R
- Hultman, C
- Lichtenstein, P
- Huckins, LM
- Leboyer, M
- Lathrop, M
- Nurnberger, J
- Steffens, M
- Foroud, TM
- Berrettini, WH
- Craig, DW
- Shi, JX
- show less...
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- University of Gothenburg
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